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Small-molecule hyaluronic acid stock solution

A technology of small molecule hyaluronic acid and stock solution, applied in the field of cosmetics, can solve the problems of no actual protection or repair effect of the dermis layer, and the duration is not long, and achieve the effects of high safety, improved skin repair, and improved compatibility.

Active Publication Date: 2019-01-25
上海阅容生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, such as the patent No. CN107157802A discloses a hyaluronic acid stock solution, although it has a certain moisturizing effect, but the duration is not long, and it has no actual protection or repair effect on the dermis.

Method used

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  • Small-molecule hyaluronic acid stock solution
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  • Small-molecule hyaluronic acid stock solution

Examples

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preparation example Construction

[0049] A method for preparing a small molecule hyaluronic acid stock solution, specifically comprising the following steps,

[0050] S1: Add the disodium EDTA and deionized water in the above parts by weight into the main pot and heat it at 90-95°C for 15-35 minutes, then lower the temperature to 70-75°C for the first time;

[0051] S2: Homogenize the sodium hyaluronate cross-linked polymer, sodium hyaluronate, acetylated sodium hyaluronate, and hydrolyzed sodium hyaluronate at 2300-2800 R / M for 2-5 minutes and then stir for 15-35 minutes. Minutes followed by the second cooling;

[0052] S3: When the temperature drops to 55-60°C for the second time in S2, add corresponding parts by weight of 1,2 pentanediol, butanediol, sodium polyglutamate, and acetyl glucosamine, and continue to cool down for the third time to After 40-45°C, add corresponding weight of purslane extract or / and gentian extract, 1,3 propylene glycol, glycerin, caprylyl hydroxamic acid, 1,2 hexanediol;

[0053...

Embodiment 1

[0061] A small molecule hyaluronic acid stock solution, which comprises the following components in parts by weight: 0.05 parts of sodium hyaluronate cross-linked polymer, 10 parts of sodium hyaluronate, 1 part of acetylated sodium hyaluronate, and 3 parts of hydrolyzed sodium hyaluronate , 0.50 parts of 1,2 pentanediol, 5 parts of butanediol, 1 part of 1,3 propylene glycol and 0.5 parts of 1,2 hexanediol, 2 parts of purslane extract, 2 parts of sodium polyglutamate, acetyl shell 2 parts of sugar amine, 0.05 part of disodium EDTA, 1 part of glycerin, 0.05 part of caprylyl hydroxamic acid, 71.4 parts of deionized water.

[0062] The preparation method of the above-mentioned small molecule hyaluronic acid stock solution is:

[0063] S1: Add the disodium EDTA and deionized water in the above parts by weight into the main pot and heat it at 90-95°C for 30 minutes, then lower the temperature to 71°C for the first time;

[0064] S2: Homogenize the sodium hyaluronate cross-linked po...

Embodiment 2

[0074] A small molecule hyaluronic acid stock solution, which includes the following components: 0.07 parts of sodium hyaluronate cross-linked polymer, 10 parts of sodium hyaluronate, 0.8 parts of acetylated sodium hyaluronate, 3.2 parts of hydrolyzed sodium hyaluronate, 0.5 parts of 1,2 pentanediol, 3 parts of butanediol, 1.2 parts of 1,3 propanediol and 0.5 parts of 1,2 hexanediol, 0.7 parts of purslane extract, 0.6 parts of gentian extract, polyglutamic acid 2.4 parts of sodium, 2 parts of acetylglucosamine, 0.04 parts of disodium EDTA, 1.2 parts of glycerin, 0.05 parts of caprylyl hydroxamic acid, and 65 parts of deionized water.

[0075] The preparation method of the above-mentioned small molecule hyaluronic acid stock solution is:

[0076] S1: Add the disodium EDTA and deionized water in the above parts by weight into the main pot and heat it at 95°C for 25 minutes, then lower the temperature to 70°C for the first time;

[0077] S2: Homogenize the sodium hyaluronate cro...

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Abstract

The invention belongs to the field of cosmetics, and specifically relates to a small-molecule hyaluronic acid stock solution. The small-molecular hyaluronic acid stock solution comprises the followingcomponent: sodium hyaluronate crosslinked polymer, sodium hyaluronate, acetylated sodium hyaluronate, hydrolyzed sodium hyaluronate, organic solvent and plant extract. A method for preparing small molecule hyaluronic acid, characterized in that: include the following steps, EDTA disodium and water are mixed and heat and then cooled for the first time, a sodium hyaluronate crosslink polymer, sodium hyaluronate, acetylate sodium hyaluronate, hydrolyzing sodium hyaluronate are added, homogenizing and stirring, and then cooling for the second time, adding 1, 2-pentanediol, butanediol, polyglutamate sodium, acetylchitosan, continue cooling for the third time, adding purslane extract, 1, 3-propylene glycol, glycerol, octanoyl hydroxamic acid, 1, 2-hexanediol, cooling for the fourth time. The small molecule hyaluronic acid stock solution of the invention has the functions of repairing and water retention, has no antiseptic system, and is safe and irritating.

Description

technical field [0001] The invention relates to a small molecule hyaluronic acid stock solution, which belongs to the field of cosmetics. Background technique [0002] Hyaluronic acid is a disaccharide unit composed of D-glucuronic acid and N-acetylglucosamine (Hyaluronan), also known as uronic acid and hyaluronic acid. The basic structure is composed of two disaccharide units D-glucuronic acid And large polysaccharides composed of N-acetylglucosamine. Unlike other mucopolysaccharides, it does not contain sulfur. Its hyaluronic molecule can carry more than 500 times of water, which is recognized as the best moisturizing ingredient today, and is widely used in skin care products and cosmetics. [0003] In the prior art, for example, a hyaluronic acid stock solution disclosed in Patent No. CN107157802A has a certain moisturizing effect, but the duration is not long, and has no actual protection or repair effect on the dermis. Contents of the invention [0004] (1) Technic...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/73A61K8/42A61Q19/00
CPCA61Q19/00A61K8/42A61K8/735A61K8/9789A61K2800/524A61K2800/30
Inventor 翁群英
Owner 上海阅容生物医药科技有限公司
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