Double-emitting fluorescent nanoparticle preparation method

A dual-emission fluorescence and nanoparticle technology, which is applied in the field of preparation of dual-emission fluorescence nanoparticles, achieves the effects of mild reaction conditions, good stability, and simple and easy-to-obtain raw materials
CN109265669AActive Publication Date: 2019-01-25XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2019-01-25

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Abstract

The invention relates to a double-emitting fluorescent nanoparticle preparation method, which comprises: covalently linking rhodamine B and a polylactic acid-glycolic acid copolymer through an intermediate linking molecule ethylenediamine to prepare a biocompatible material Rhodamine B modified polylactic acid-glycolic acid copolymer with fluorescence emission function, and encapsulating a fluorescent tracer with the fluorescent biocompatible material to obtain the double-emitting fluorescent nanoparticles. According to the present invention, the preparation method has characteristics of simple and easily-available raw materials and mild reaction conditions, and the prepared double-emitting fluorescent nanoparticles have characteristics of smooth and complete surface, uniform particle sizedistribution, good stability and good dual fluorescence emission performance, can achieve visual monitoring, can be used in the fields of clinical diagnosis and drug evaluation, and has good application prospects.
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Description

technical field

[0001] The invention belongs to the technical field of nanometer preparation, and in particular relates to a method for preparing double-emission fluorescent nanoparticles. Background technique

[0002] Polylactic acid-glycolic acid copolymer (PLGA) is a polymer material polymerized by lactic acid and glycolic acid according to a certain ratio, and its degradation products are lactic acid and glycolic acid, which are also human metabolites. Due to its good biocompatibility, biodegradability, stable quality, and adjustable degradation rate, it has been widely used as a carrier material for micro-nano controlled release and targeting systems in recent years.

[0003] In order to characterize the behavior of nanoparticles in cells or in vivo, nanoparticles are usually loaded with a certain amount of fluorescent dyes to trace the transport and distribution behavior of the nanoparticles. However, the environment of cells or in vivo is complex. After release, this...

Claims

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