A kind of anti-adhesion polyvinyl alcohol embolic microspheres and its preparation method and application

Abstract

The invention provides an anti-adhesion polyvinyl alcohol embolization microsphere, and a preparation method and an application thereof, and belongs to the field of intervention polymer embolization materials. Positively charged or negatively charged polysaccharides are added in a process for preparing polyvinyl alcohol microspheres by reverse suspension crosslinking to make Coulomb repulsive force among the microspheres and the microspheres repulse each other in order to obtain the embolization microsphere with a high sphericity, non-adhesion and a controllable particle size. The anti-adhesion polyvinyl alcohol embolization microsphere has the advantages of simple preparation method, mild preparation conditions, low cost, suitableness for large-scale mass production, and broad applicationprospect in the field of clinical interventional medicine.

Description

technical field [0001] The invention relates to a preparation method of macromolecular embolization microspheres for interventional treatment of tumors, in particular to an anti-adhesion polyvinyl alcohol embolization microsphere and its preparation method and application. Background technique [0002] In recent years, with the intensification of environmental pollution, people's irregular living habits and the aging of the population, the related malignant tumors such as lung cancer, liver cancer, gastric cancer, and rectal cancer have shown an increasing trend year by year. The common treatment methods for malignant tumors are surgical resection, radiotherapy and chemotherapy, which have many disadvantages such as large side effects and high cost. For patients with advanced disease, Transcatheter arterial embolization (TAE) provides a new treatment method for the majority of patients. It has many advantages such as good targeting, minimally invasive, and low complications...

AI Technical Summary

Problems solved by technology

Generally, in the process of emulsification and crosslinking, the particle size of polyvinyl alcohol microspheres can be increased by increasing the concentration of polyvinyl alcohol, reducing the ratio of oil / water phase, reducing the stirring speed, and reducing the concentration of surfactants, but polyvinyl alcohol It has a certain viscosity, and it also increases the probability of microsphere collision and adhesion during the stirring process. The addition of cross-linking agent is likely to cause large adhesion of the microspheres that stick together; if the process of preparing microspheres is passed Reducing the concentration of polyvinyl alcohol, increasing the ratio of oil / water phase, increasing the stirring speed or increasing the concentration of emulsifier can make the microspheres isolated from each other in the oil phase, reduce the probability of collision and adhesion of the microspheres, and make the prepared microspheres more dispersed At the same time, the particle size of the microspheres will also decrease, which may not meet the particle size requirements for specific tumor embolization

Therefore, the preparation of polyvinyl alcohol microspheres with a larger particle size and non-cohesion is not easy to control during actual operation.

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