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Tea tree oil aerosol inhalation agent and preparation technology thereof

An atomized inhalant and preparation technology, applied in the field of pharmacy, can solve problems such as the blockage of the spray nozzle of the atomizer, the insoluble tea tree oil in water, and the inability to make water-soluble preparations, etc., and achieve high bioavailability and low bioavailability. Dosage for fast and effective results

Inactive Publication Date: 2019-02-05
CHONGQING ZHIYAN TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports on the use of tea tree oil for atomization therapy, and because tea tree oil is insoluble in water, it cannot be made into water-soluble preparations
Existing atomizers cannot form the aerosol particle size range required for respiratory drug deposition, and the spray nozzle of the atomizer is easily blocked

Method used

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  • Tea tree oil aerosol inhalation agent and preparation technology thereof
  • Tea tree oil aerosol inhalation agent and preparation technology thereof
  • Tea tree oil aerosol inhalation agent and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A tea tree oil atomized inhalation, 1L of the atomized inhalation includes the following components: 5g of tea tree oil, 5g of soybean lecithin, 0.65g of sodium deoxycholate, 65g of ethanol, and the balance is water. The pH value is 7. Prepare as follows:

[0036] First, dissolve 5 g of solubilizer I (soybean lecithin) in 65 g of absolute ethanol to obtain solution A; then dissolve 0.65 g of solubilizer II (sodium deoxycholate) in water, and then add 5 g of tea tree oil until the mixed solution is clear to obtain solution B; finally, add solution B to solution A, stir and dilute to 1L with water.

Embodiment 2

[0038] A tea tree oil atomized inhalation, 1L of the atomized inhaler includes the following components: 7g of tea tree oil, 4g of egg yolk phospholipid, 0.5g of sodium cholate, 45g of ethanol, and the balance is water. The pH of the atomized inhaler is 7.5. Prepare as follows:

[0039] First, dissolve 4g of solubilizer I (egg yolk phospholipid) in 45g of absolute ethanol to obtain solution A; then dissolve 0.5g of solubilizer II (sodium cholate) in water, and then add 7g of tea tree oil until the mixed solution is clear. Obtain solution B; finally add solution B to solution A, stir and dilute to 1L with water.

Embodiment 3

[0041] A tea tree oil atomized inhalation, 1L of the atomized inhalation includes the following components: 3g of tea tree oil, 3g of hydrogenated soybean lecithin, 0.7g of sodium ursodeoxycholate, 0.02mol of sodium chloride, 0.02mol of citric acid, phosphoric acid 0.03 mol of disodium hydrogen, 30 g of ethanol, and water as the balance, the pH value of the atomized inhalation is 8. Prepare as follows:

[0042] First, dissolve 3g of solubilizer I (hydrogenated soybean lecithin) in 30g of absolute ethanol to obtain solution A; and 0.05mol buffer (0.02mol citric acid and 0.03mol disodium hydrogen phosphate) were dissolved in water, and then 3g of tea tree oil was added until the mixed solution was clear to obtain solution B; finally, solution B was added to solution A, stirred with water Set the volume to 1L, that's it.

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Abstract

The invention relates to a tea tree oil aerosol inhalation agent and a preparation technology thereof, and belongs to the technical field of preparation study. In the technology, an ethanol solution of a solubilizer I is prepared first, then the ethanol solution of the solubilizer I is mixed with tea tree oil and an aqueous solution of a solubilizer II to form a uniform system; thus, the defect ofa conventional method that the tea tree oil is first dissolved in the ethanol solution of the solubilizer I and then is mixed with the aqueous solution of the solubilizer II and consequently the prepared tea tree oil aerosol inhalation agent system is unstable can be effectively avoided. Through reasonable setting of the content of each component in the tea tree oil aerosol inhalation agent, thedispersity of the tea tree oil in water is further guaranteed, and the finally prepared aerosol inhalation agent has both uniformity and stability; when applied to atomization, the aerosol inhalationagent can form aerosol particles with particle size of 2-15 mu m and thus can be better used for treating the diseases of a respiratory system such as chronic pharyngitis, chronic bronchitis and upperrespiratory infection. Specially designed for the patients in aerosol inhalation, the tea tree oil aerosol inhalation agent provided by the invention is matched with an atomizer and has the advantages of convenience in use and high safety.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a tea tree oil atomized inhaler and a preparation process thereof. Background technique [0002] Respiratory diseases are the most common diseases in life and the diseases with the highest outpatient visits, especially for the elderly and children. Taking children's asthma as an example, the total prevalence rate in major urban areas of my country has reached 3.02%. As the first choice for the treatment of respiratory diseases, nebulized inhalation therapy has been widely recommended by domestic and foreign guidelines for clinical use in pediatrics and respiratory departments, and is gradually applied to home treatment of chronic diseases such as asthma, COPD, bronchitis, and pharyngitis. In terms of safety, effectiveness and convenience, aerosol inhalation therapy has become the first choice for children and the elderly suffering from respiratory diseases. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K36/61A61K9/08A61P11/04A61P11/00
CPCA61K9/08A61K9/0078A61K36/61A61P11/00A61P11/04
Inventor 佟丽
Owner CHONGQING ZHIYAN TECH DEV