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Preparation method and application of a kresoxim-like molecularly imprinted polymer

A molecular imprinting, polymer technology, applied in the directions of alkali metal compounds, chemical instruments and methods, ion exchange, etc., can solve problems such as limiting the use of MIPs, and achieve the effects of good selectivity, small particle size and strong adsorption capacity

Active Publication Date: 2021-02-02
BEIJING UNIV OF AGRI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current MIPs imprint a single template, which only has high selectivity for the template itself, thus limiting the use of MIPs

Method used

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  • Preparation method and application of a kresoxim-like molecularly imprinted polymer
  • Preparation method and application of a kresoxim-like molecularly imprinted polymer
  • Preparation method and application of a kresoxim-like molecularly imprinted polymer

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preparation example Construction

[0017] A method for preparing molecularly imprinted polymers of kresoxystrobin, using kresoxystrobin and pyraclostrobin as template molecules, using methacrylic acid as a functional monomer, and using trimethylolpropane trimethacrylate as crosslinking molecules. Linking agent for polymerization reaction, and then remove unpolymerized functional monomers, cross-linking agents and template molecules in the polymer to obtain the final product.

[0018] In the present invention, by selecting p-krysstrobin and pyraclostrobin as template molecules, molecularly imprinted polymer microspheres (MIP) with high "class" specificity and selectivity have been synthesized, and at the same time, it can be realized that p-krysstrobin and pyraclostrobin Detection of pyraclostrobin.

[0019] The selection of functional monomers has a great influence on the adsorption properties of molecularly imprinted polymers, which needs to be selected according to the structure and basic properties of templa...

Embodiment 1

[0042] Example 1 Preparation of Molecularly Imprinted Polymer

[0043] 1. In a 100mL ground glass bottle, add 0.8mmol kysstrobin, 1.2mmol pyraclostrobin, 8mmol functional monomer methacrylic acid and 75mL acetonitrile-toluene solution (7:3, v / v) Set 2h;

[0044] 2. Add 20mmol of trimethylolpropane trimethacrylate and 50mg of 2,2` azobisisobutyronitrile, ultrasonically mix, then pass high-purity nitrogen gas under ice-water bath conditions for 10min, and seal with a ground glass stopper. Polymerization in a water bath at 65°C for 28 hours;

[0045] 3. After cooling to room temperature, centrifuge at 3000r / min for 10min to obtain the precipitated polymer, and perform Soxhlet extraction with a mixed solution of acetic acid and methanol with a volume ratio of 1:9, the extraction time is 20h, and the temperature is 80°C;

[0046] 4. Shake elution with methanol, place the finally obtained polymer beads in a vacuum oven at 60°C and vacuum-dry to constant weight to obtain kresoxim-l...

Embodiment 2

[0047] Example 2 Preparation of Molecularly Imprinted Polymer

[0048] 1. In a 100mL ground glass bottle, add 1mmol kysstrobin, 0.8mmol pyraclostrobin, 4mmol functional monomer methacrylic acid and 65mL acetonitrile-toluene solution (7:3, v / v), and let stand at room temperature 2.5 hours;

[0049] 2. Add 40mmol of trimethylolpropane trimethacrylate and 45mg of 2,2` azobisisobutyronitrile, ultrasonically mix, then pass high-purity nitrogen gas under ice-water bath conditions for 15min, and seal with a ground glass stopper. Polymerization was carried out in a water bath at 72°C for 24 hours;

[0050] 3. After cooling to room temperature, centrifuge at 2000r / min for 8min to obtain the precipitated polymer, and perform Soxhlet extraction with a mixed solution of acetic acid and methanol with a volume ratio of 1:8, the extraction time is 24h, and the temperature is 85°C;

[0051] 4. Shake elution with methanol, place the finally obtained polymer beads in a vacuum oven at 60°C and...

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Abstract

The invention relates to the field of compound extraction and separation and purification, in particular to a preparation method and application of a kresoxim-like molecularly imprinted polymer. The preparation method uses kysoxystrobin and pyraclostrobin as template molecules, methacrylic acid as functional monomer, and trimethylolpropane trimethacrylate as cross-linking agent for polymerization reaction, and then removes unpolymerized The functional monomers, cross-linking agents and template molecules in the polymer can be obtained. The molecularly imprinted polymer of kresoxim-methyl was prepared by the precipitation polymerization method, and the molecularly imprinted polymer can realize the specific recognition of kresoxim-methyl and pyraclostrobin, thereby realizing the The separation, enrichment and purification of esters provide a purification method for the residue detection of kysstrobin and pyraclostrobin in the environment and agricultural products.

Description

technical field [0001] The invention relates to the field of compound extraction and separation and purification, in particular to a preparation method and application of a kresoxim-like molecularly imprinted polymer. Background technique [0002] Methoxyacrylate fungicides were discovered on the basis of the natural product β-methoxyacrylate. Through in-depth research on methoxyacrylate fungicides, it is found that the mechanism of action of this kind of fungicides is to play a bactericidal effect by interfering with the respiration of pathogenic fungi. It is a fungal cytochrome bc1 respiration inhibitor. Due to the continuous increase in the use of methoxyacrylate fungicides and the increasing residues, the problem of residues of such fungicides has attracted the attention of relevant management departments in various countries around the world. Many countries and relevant organizations have stipulated this Residue limits for fungicides. [0003] BASF developed a highly ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/06C08J9/28B01J20/26B01J20/28B01J20/30B01D15/08
CPCB01D15/08B01J20/268B01J20/28021B01J20/28057C08F222/14C08J9/28C08J2335/04C08F222/103C08F220/06
Inventor 贾明宏
Owner BEIJING UNIV OF AGRI