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Use of physicine in the preparation of medicines for treating allergic diseases

A technology for allergy and disease treatment, which is applied in the field of medicine and can solve problems such as limited application

Inactive Publication Date: 2020-08-11
魏姗姗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of drug has a strong central nervous system inhibitory effect, so its application is limited

Method used

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  • Use of physicine in the preparation of medicines for treating allergic diseases
  • Use of physicine in the preparation of medicines for treating allergic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Chessine external gel

[0034] Raw and auxiliary materials: 10g of chrysanthemum, 20g of carbomer 940, 450g of glycerin, 50g of triethanolamine, 0.2g of disodium edetate, and distilled water to 1000g.

[0035] Preparation: Weigh 10g of chiseline, 0.2g of disodium edetate, add appropriate amount of distilled water to dissolve, add 450g of glycerin and mix, grind evenly, add 20g of carbomer 940 under stirring, let it sit overnight to fully swell, slowly add three Make a gel with 50g of ethanolamine, add water to 1000g, and pack it separately.

Embodiment 2

[0036] Example 2 Chessine Oral Tablets

[0037] Raw and auxiliary materials: 200g of chrysanthemum, 250g of sodium starch glycolate, 400g of starch, 500g of maltodextrin, and 10g of magnesium stearate.

[0038] Preparation: Weigh 200 g of chrysanthemum, 250 g of sodium starch glycolate, 400 g of starch, and 500 g of maltodextrin, grind them respectively, and pass through a 100-mesh sieve; weigh 10 g of magnesium stearate and pass through a 40-mesh sieve; Carboxymethyl starch sodium and maltodextrin are mixed, the starch is prepared into 10% starch slurry, and the mixture of chessanine, carboxymethyl starch sodium and maltodextrin is added to prepare soft material; the obtained soft material is granulated through a 16-mesh sieve, 70 After drying at ℃, pass through a 16-mesh sieve for granulation, then add magnesium stearate, mix evenly, and press into tablets.

Embodiment 3

[0039] Example 3 Chessine Injection

[0040] Raw and auxiliary materials: 10g of chrysanthemum, 100g of hydroxypropyl-β-cyclodextrin, 50ml of ethanol, 2000ml of water for injection.

[0041] Preparation: Weigh 10g of phylloxine and add it into 50ml of ethanol; weigh 100g of hydroxypropyl-β-cyclodextrin and dissolve it in 2000ml of water for injection. Add the ethanol mixture of cheeserine to hydroxypropyl-β-cyclodextrin aqueous solution, stir at room temperature at 100 rpm for 3 hours, filter through a microporous membrane to remove the pyrogen, and pack into 1000 injections.

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Abstract

The invention belongs to the field of medicines and particularly relates to application of zygadenine in preparation of allergic disease treatment drugs. It is shown through research that the vascularpermeability caused by histamine is increased by the zygadenine, and the zygadenine has the certain improvement effect on allergic shock caused by allergens. The administration way of the zygadenineis preferably oral administration or intravenous injection administration.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of chrysanthemum in the preparation of medicines for treating allergic diseases. Background technique [0002] Allergic diseases, also known as allergic diseases, are physical symptoms caused by allergic allergies. Such diseases are usually triggered by the human body in contact with antigenic substances, resulting in the disorder of physiological functions or tissue damage due to excessive immune response. The antigenic substances of allergic diseases, that is, allergens, are very extensive. Plant pollen, dust mites, fungal spores, drugs, etc. entering the body may induce acute or chronic allergic diseases. Such as allergic rhinitis, allergic asthma, urticaria, eczema, angioedema, allergic gastritis, drug eruption, etc. Some of these allergic diseases, such as drug allergies, develop rapidly and have serious effects on key systems such as the respiratory and cardiov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P37/08A61P37/00A61P33/14A61P11/06A61P17/00
CPCA61K31/4375A61P11/06A61P17/00A61P33/14A61P37/00A61P37/08
Inventor 魏姗姗朱秀丽李颖
Owner 魏姗姗