A kind of antipyretic analgesic powder and preparation method thereof

An antipyretic and analgesic, formula technology, applied in the directions of non-central analgesics, anti-inflammatory agents, antipyretics, etc., can solve the problems of uneven mixing of medicinal powder, unstable aspirin, increased adverse reactions, etc., to reduce exposure Time, production operation process is convenient and fast, and the effect of easy packaging

Active Publication Date: 2021-05-04
GUANGZHOU BAIYUNSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Guangdong Taicheng Pharmaceutical Co., Ltd.'s application number is 201410209872.9 for the invention patent "Acafeol powder and its preparation method", which uses the raw and auxiliary materials in the prescription to be mixed and then pulverized, which may easily cause uneven mixing of the drug powder, and, for Acafe The aspirin in the coffee powder is likely to cause instability, thereby reducing the content and increasing the adverse reactions

Method used

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  • A kind of antipyretic analgesic powder and preparation method thereof

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preparation example Construction

[0031] The preparation method of this antipyretic analgesic powder comprises the following steps:

[0032] The step of feeding: Weigh the aspirin, acetaminophen and caffeine of the formula amount, and feed them through the vacuum feeder in an alternate feeding mode; as a further preferred solution, in the step of feeding, the formula amount is calculated in parts by weight As follows: 230 parts of aspirin, 126 parts of acetaminophen, 30 parts of caffeine. As a further preferred solution, the method of alternate feeding is as follows: the aspirin, acetaminophen, and caffeine in the formula are divided into several parts respectively, and each raw material is alternately added to the crushing and vibrating powder sieve machine, and the adjacent raw materials are not repeated. . As a further preferred solution, the vacuum feeder of the present invention is selected from the vacuum feeder machine that Tianjin Yunfei Machinery Co., Ltd. provides model as ZKS-4; the feeding time of...

Embodiment 1

[0040] A preparation method of antipyretic and analgesic powder, comprising the following steps:

[0041] Feeding steps: Weigh the aspirin, acetaminophen, and caffeine of the formula, and feed them through the vacuum feeder in an alternate feeding manner;

[0042]Weigh aspirin, acetaminophen, and caffeine according to the production prescription. Specific operation: Weigh 3 parts by weight of 42 parts of acetaminophen, a total of 126 parts; weigh 3 parts of 10 parts by weight of caffeine, a total of 30 parts; weigh 5 parts of 38 parts by weight and 1 part of 40 parts by weight , that is, a total of 230 servings of aspirin. The feeding order is as follows: 2 servings of aspirin → 1 serving of caffeine → 1 serving of paracetamol → 2 servings of aspirin → 1 serving of caffeine → 1 serving of paracetamol → 2 servings of aspirin → 1 serving 1 serving of caffeine → 1 serving of acetaminophen.

[0043] The vacuum feeder is selected from the vacuum feeder model ZKS-4 provided by Ti...

Embodiment 2

[0049] A preparation method of antipyretic and analgesic powder, comprising the following steps:

[0050] Feeding steps: Weigh the aspirin, acetaminophen, and caffeine of the formula, and feed them through the vacuum feeder in an alternate feeding manner;

[0051] Weigh aspirin, acetaminophen, and caffeine according to the production prescription. Specific operation: Weigh 3 parts by weight of 42 parts of acetaminophen, a total of 126 parts; weigh 3 parts of 10 parts by weight of caffeine, a total of 30 parts; weigh 5 parts of 38 parts by weight and 1 part of 40 parts by weight , that is, a total of 230 servings of aspirin. The feeding order is as follows: 2 parts of aspirin → 1 part of caffeine → 1 part of acetaminophen → 2 parts of aspirin → 1 part of caffeine → 1 part of acetaminophen → 2 parts of aspirin → 1 part of caffeine → 1 part of paracetamol Aminophenols.

[0052] The vacuum feeder is selected from the vacuum feeder model ZKS-4 provided by Tianjin Yunfei Machiner...

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Abstract

The invention discloses an antipyretic and analgesic powder and a preparation method thereof. The antipyretic and analgesic powder is composed of aspirin, paracetamol, caffeine and silicon dioxide. The preparation method of antipyretic and analgesic powder comprises the following steps: a step of feeding materials, a step of sieving, a step of mixing, a step of discharging, and a step of packaging, to obtain a single-dose packaged of antipyretic and analgesic powder. Silicon dioxide is added to the antipyretic and analgesic powder, so that the powder has better fluidity and is easy to be packaged. The raw materials of the preparation method are fed and sifted through a vacuum feeder, a crushing vibrating powder sifter, and a vacuum feeding system to reduce the exposure time of the medicinal powder.

Description

technical field [0001] The invention relates to a preparation method technology of an antipyretic analgesic powder, in particular to an antipyretic analgesic powder and a preparation method thereof. Background technique [0002] Aspirin mainly inhibits the synthesis of prostaglandins and other substances that can sensitize pain to mechanical or chemical stimuli (such as bradykinin, histamine), and belongs to peripheral analgesics. In addition, it can cause peripheral blood vessels to dilate by acting on the hypothalamic thermoregulation center, increase skin blood flow, sweat, and increase heat dissipation to play an antipyretic effect. [0003] Acetaminophen achieves antipyretic and analgesic effects mainly by inhibiting the synthesis and release of prostaglandins. [0004] Caffeine is a central nervous system stimulant, mainly by constricting cerebral blood vessels, relieving headaches caused by cerebral vasodilation, thereby enhancing the efficacy of antipyretic and anal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K47/04A61K31/616A61K31/167A61K31/522A61P29/00
CPCA61K9/143A61K31/167A61K31/522A61K31/616A61P29/00A61K2300/00
Inventor 陈溪朱岁华高燕
Owner GUANGZHOU BAIYUNSHAN PHARM CO LTD
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