Rapamycin ointment for treating vascular malformation and preparation method thereof

Abstract

The invention discloses rapamycin ointment for treating vascular malformation and a preparation method thereof. The rapamycin ointment is prepared from 0.05 to 0.2 g of rapamycin, 40 to 50 g of a grease type matrix, 2 to 5 g of paraffin wax, 2 to 5 g of a transdermal osmosis promoter, 1 to 4 g of an organic solvent, 0 to 0.5 g of a preservative and 0.5 to 2 g of a surfactant; the preparation method comprises the following steps of: weighing the grease type matrix and the paraffin wax; heating in a water bath to 70 to 90 DEG C and melting; then cooling to 50 to 60 DEG C; adding the rapamycin into the organic solvent and dissolving; then mixing with the grease type matrix and the paraffin wax; finally, adding residual components of the preservative, the transdermal osmosis promoter and the surfactant and mixing and stirring for 1 to 2 h to obtain the rapamycin ointment. The rapamycin ointment provided by the invention has a good transdermal effect, is convenient to use and can be used for treating shallow-layer vascular malformation with irregular shapes.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a rapamycin ointment for treating vascular malformations and a preparation method thereof. Background technique [0002] Vascular malformation (vascular tumor), also known as cast tumor, its main pathology is the excessive proliferation of vascular endothelial cells and the formation of abnormal vascular lumen. At present, the pathogenesis and mechanism of vascular malformation are still unclear. In clinical practice, the treatment of vascular malformation should be comprehensively considered according to the type, location, depth, and age of the patient. The current treatment methods include surgical resection, radiation therapy, hormone therapy, etc. therapy, hypothermia, laser therapy, sclerotherapy injections, drug therapy, etc. There is no one way to treat all types of vascular malformations. Surgical treatment and injection treatment are suitable for patients with mor...

AI Technical Summary

Problems solved by technology

Patients with mild conditions are suitable for oral and external drug therapy, but oral therapy is likely to cause systemic absorption of toxic and side effects, which is very unfavorable for patients with long drug cycles

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