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Criborole cubic liquid crystal gel preparation and preparation method thereof

A technology of crisborole and gel preparations, which is applied in the field of crisborole cubic liquid crystal gel preparations and its preparation, can solve the problems of poor skin targeting and poor skin permeability, and achieve low production costs and improved stability Sexuality and good application prospects

Active Publication Date: 2021-12-28
苏州高迈药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Based on this, the present invention provides a crisborole cubic liquid crystal gel preparation and a preparation method thereof, so as to overcome the disadvantages of poor skin permeability and poor skin targeting in the prior art.

Method used

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  • Criborole cubic liquid crystal gel preparation and preparation method thereof
  • Criborole cubic liquid crystal gel preparation and preparation method thereof
  • Criborole cubic liquid crystal gel preparation and preparation method thereof

Examples

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preparation example Construction

[0060] I. Preparation of boron Rom cubic liquid Peclet gel

[0061] Table 1 Law cubic liquid Peclet boron gel formulation (%: by weight)

[0062]

[0063]

[0064] Preparation of formulation in Table 1:

[0065] Preparation of cubic liquid Peclet boron Lo gel binary system: Prescription 1-3

[0066] Mass ratio in Table 1 were weighed amount of glycerol monooleate and boron Lo Peclet on a water bath 45 ℃ sufficiently dissolved uniformly mixed, then purified water was added prescribed amount and / or preservatives and antioxidants, in shock is mixed, placed 7 days 25 ℃, cubic liquid crystals to give a gel formulation 1-3.

[0067] Prescription 4-10, Comparative Example 4, 5: Preparation of cubic liquid Peclet boron Lo gel ternary system

[0068] Table 1 mass ratio in an appropriate amount of weighed liquid carrier material, propylene glycol, boron Lo Kerry on a water bath 45 ℃ sufficiently dissolved uniformly mixed, then purified water was added prescribed amount and / or preser...

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Abstract

The invention relates to a crisborole cubic liquid crystal gel preparation and a preparation method thereof. The crisborole cubic liquid crystal gel preparation of the present invention, based on the total mass of the preparation, includes the following components by weight percentage: liquid crystal carrier material: 20-60%; crisborole: 0.1%-5%; 1 , 2-propylene glycol: 0-20%; the rest is water; the liquid crystal carrier material is selected from glycerol monooleate. The crisborole cubic liquid crystal gel preparation of the present invention has the advantages of no stimulation, high stratum corneum transmittance, remarkable slow-release effect, good skin targeting, and the like.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical preparations, in particular liquid crystal cubic boron Lo gel formulation and preparation method relates to a Kriging. Background technique [0002] Kerry boron Luo, English called Crisaborole, the chemical structural formula is as follows: [0003] [0004] Kerry boron Luo December 14, 2016 the US FDA clearance to market, called by the Anacor pharmaceutical R & D, product Boron a Peclet Luo phosphodiesterase -4 (PDE-4) inhibitors, such inhibition results in cellular cyclic adenosine monophosphate (cAMP) levels increased; For patients over 2 years of age and topical treatment of mild to moderate atopic dermatitis, listed on the dosage form is a topical ointment. [0005] The traditional way of transdermal ointment formulations are mainly absorbed by the skin appendages and cuticle, because the proportion of skin appendages (such as hair follicles, sebaceous glands) accounted for only 0.1% of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/69A61K47/10A61K47/14A61K9/127A61P17/00A61P37/08
CPCA61K47/10A61K47/14A61P17/00A61P37/08A61K9/0014A61K9/06A61K9/1274A61K31/69
Inventor 胡春丽陈水艳
Owner 苏州高迈药业有限公司