Calcium alginate-graphene oxide nanofiber and preparation method and drug-carrying calcium alginate-graphene oxide nanofiber

A calcium alginate and nanofiber technology, applied in the chemical characteristics of fibers, alginate man-made filaments, pharmaceutical formulations, etc., can solve the problems of strong hygroscopicity and low mechanical strength, achieve a good therapeutic effect, and reduce the release rate. , to avoid the effect of sudden release

Active Publication Date: 2019-03-15
WUYI UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] One of the objectives of the present invention is to provide a preparation method of calcium alginate-graphene oxide nanofibers, so as to alleviate the phenomenon of sudden release of drugs in aqueous solution due to the strong hygroscopicity and low mechanical strength of existing sodium alginate fibers technical issues

Method used

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  • Calcium alginate-graphene oxide nanofiber and preparation method and drug-carrying calcium alginate-graphene oxide nanofiber

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preparation example Construction

[0030] According to one aspect of the present invention, the present invention provides a method for preparing calcium alginate-graphene oxide nanofibers, comprising the following steps: passing a mixed solution of sodium alginate and graphene oxide and a calcium chloride solution through a microfluidic control Spinning to obtain calcium alginate-graphene oxide nanofibers.

[0031] The preparation method of the calcium alginate-graphene oxide nanofiber provided by the present invention is prepared by microfluidic spinning, the process is simple and convenient to operate, and the prepared calcium alginate-graphene oxide is obtained by adding graphene oxide into the raw material The nanofibers interact with the hydroxyl group in the calcium alginate molecule through the oxygen-containing groups on the graphene oxide sheet, which weakens the hydrogen bond between the calcium alginate and the water molecule, thereby reducing the swelling of the calcium alginate rate, to prevent th...

Embodiment 1

[0080] This embodiment provides drug-loaded calcium alginate-graphene oxide nanofibers, which are prepared according to the following steps:

[0081] (1) With distilled water as solvent, configure the mixed solution of rhodamine B, sodium alginate and graphene oxide, wherein, the mass concentration of sodium alginate is 2%, the mass concentration of graphene oxide is 0.1%, the mass concentration of rhodamine B The mass concentration is 1%;

[0082] (2) Using distilled water as a solvent, configure a calcium chloride solution, wherein the concentration of the calcium chloride solution is 1%;

[0083] (3) Using a dual-channel microfluidic chip to prepare drug-loaded calcium alginate-graphene oxide nanofibers, the mixed solution of rhodamine B, sodium alginate and graphene oxide is transported to the silk outlet channel through the first channel , the flow rate is 100mL / h; the calcium chloride solution is transported to the silk outlet channel through the second channel, and the...

Embodiment 2

[0085] This embodiment provides a drug-loaded calcium alginate-graphene oxide nanofiber. The difference between its preparation method and Example 1 is that in step (1), the mass concentration of sodium alginate is 6%. In step (2), the mass concentration of calcium chloride is 3%.

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Abstract

The invention provides a calcium alginate-graphene oxide nanofiber and a preparation method and a drug-carrying calcium alginate-graphene oxide nanofiber and relates to the technical field of nanofibers. The preparation method of the calcium alginate-graphene oxide nanofiber comprises the following step: carrying out microfluidics spinning on a mixed solution of calcium alginate and graphene oxideand a calcium chloride solution, thereby obtaining the calcium alginate-graphene oxide nanofiber. The technical problem that a sudden drug release phenomenon is caused as a conventional calcium alginate nanofiber is good in hygroscopicity and low in mechanical strength is alleviated. By adopting the preparation method provided by the invention, the graphene oxide is put into raw materials, so that the calcium alginate-graphene oxide nanofiber has hydrogen bond interactions with oxygen-containing groups on a graphene oxide sheet and hydroxyl in calcium alginate molecules, the hydrogen bond function of the calcium alginate and water molecules is weakened, the swelling velocity of the calcium alginate is reduced, and the sudden drug release phenomenon can be prevented.

Description

technical field [0001] The invention relates to the technical field of nanofibers, in particular to calcium alginate-graphene oxide nanofibers, a preparation method and drug-loaded calcium alginate-graphene oxide nanofibers. Background technique [0002] In order to make drug delivery more efficient, convenient, safe and stable, pharmacy has entered the era of a new drug delivery system. Sodium alginate is a linear polysaccharide extracted from brown seaweed, composed of β-D-mannuronic acid (M unit) and α-L-guluronic acid (G unit) through 1,4-glycosidic bonds Homopolymers (GG, MM) and copolymers (GM) are composed of fragments of G units and M units in different proportions on the structural units. Such structural characteristics and structural units make alginate have good film-forming properties, easy gelation properties and biological therapeutic effects, so that it has been valued and developed in the field of biomedicine. Using sodium alginate to make sodium alginate f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F9/04D01F1/10A61K47/36
CPCA61K47/36D01F1/10D01F9/04
Inventor 于晖许丽群蔡洁李英毅朱吉昌曾健豪郭永诗黄琪帏邹捷
Owner WUYI UNIV
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