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Raman sensor and production method thereof

A sensor and graphene technology, applied in the field of cancer diagnosis, can solve the problems of limited application, low sensitivity, weak signal, etc., and achieve the effect of improving sensitivity, increasing Raman signal, and regular shape

Active Publication Date: 2019-03-19
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the signal of traditional Raman scattering is weak and the sensitivity is not high, which limits its application

Method used

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  • Raman sensor and production method thereof
  • Raman sensor and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In this example, all the chemical reagents used were of analytical grade or above. Chlorauric acid (HAuCl 4 4H 2 O), concentrated sulfuric acid, potassium permanganate, concentrated hydrochloric acid and sodium hydroxide (NaOH) were purchased from China National Pharmaceutical Co., Ltd. Rhodamine 6G (C 28 h 31 N 2 o 3 Cl) was purchased from Shanghai Aladdin Reagent Co., Ltd. The 8 amino acid markers used were purchased from SigmaAldrich (Sigma, USA). The deionized water used in the experiment was prepared in real time by Millipore-Q ultrapure water system (Millipore, USA), and the conductivity was not lower than 18.2 MΩcm.

[0033] Preparation of Graphene Oxide (GO)

[0034] The preparation of graphene oxide is carried out according to the common preparation method Hummer method. Briefly, firstly, potassium permanganate (KMnO 4 ) and concentrated sulfuric acid (H 2 SO 4 ) after the graphite flakes are oxidized, followed by ultrasonic peeling, and finally the...

Embodiment 2

[0049] Adopt the reagent identical with embodiment and identical preparation method, difference is:

[0050] (1) Graphene oxide and HAuCl in graphene oxide solution 4 HAuCl in solution 4 The mass ratio is 1:1;

[0051] (2) Add sodium hydroxide under the condition of rotating speed of 300rpm, adjust the pH to 9, then perform hydrothermal reaction at 100°C for 15h, and finally obtain the Raman sensor by centrifugation.

[0052] The Raman sensor obtained in this example was subjected to the same detection as in Example 1, which proved that the Raman sensor had good sensitivity.

Embodiment 3

[0054] Adopt the reagent identical with embodiment and identical preparation method, difference is:

[0055] (1) Graphene oxide and HAuCl in graphene oxide solution 4 HAuCl in solution 4 The mass ratio is 1:10;

[0056] (2) Add sodium hydroxide under the condition of rotating speed of 700rpm, adjust the pH to 13, then perform hydrothermal reaction at 140°C for 10h, and finally obtain the Raman sensor by centrifugation.

[0057] The Raman sensor obtained in this example was subjected to the same detection as in Example 1, which proved that the Raman sensor had good sensitivity.

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Abstract

The invention relates to a Raman sensor and a production method thereof. A Raman sensor substrate comprises a graphene carrier and nano gold particles grown in situ on the graphene carrier. Upon preparation, graphene oxide solution and HAuCl4 solution are mixed well; pH is adjusted to alkaline level under violent stirring; hydrothermal reaction is carried out; separation is performed to obtain theRaman sensor substrate; the synthesized Raman sensor substrate is dropwise added onto a gold membrane about 200 nm in thickness; the Raman sensor is produced then by drying. Compared with the prior art, the Raman sensor and the production method thereof have the advantages that no additional reducing agents and stabilizers are used, gold nano particles uniform in size are directly grown in situ on the surface of graphene, the adsorbing property of carbon nano material and hotspot effect of the gold nano particles are effectively combined to construct the Raman sensor substrate which is good and clean. Background interference signal is weak, and sensitivity of the Raman sensor is evidently improved.

Description

technical field [0001] The invention relates to the technical field of cancer diagnosis, in particular to a Raman sensor and a preparation method thereof. Background technique [0002] Cancer is a major disease that threatens people's lives. Among them, gastric cancer is one of the common malignancies, its incidence rate ranks fourth among common tumors, and its mortality rate ranks second. In recent years, although the mortality rate of gastric cancer has decreased, its incidence rate remains high among all malignant tumors. In addition, early detection of gastric cancer is difficult, and gastric cancer is often diagnosed at an advanced stage. In my country, about 150,000 to 200,000 gastric cancer patients die each year, and about 200,000 new patients are diagnosed as gastric cancer patients. At present, there is still a lack of effective means to diagnose and overcome gastric cancer in the world. Today, the main diagnostic methods in medicine are gastroscopy and gastro...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/65
Inventor 崔大祥章阿敏常杰黄志成
Owner SHANGHAI JIAO TONG UNIV
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