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Green production process of glutamic acid

A green production, glutamic acid technology, applied in the green production process of glutamic acid, can solve the problems of low nutritional value of hydrolyzate, difficult to control the fermentation process, fermentation instability and other problems, to reduce high pigment content and less impurities , The effect of reducing industrial costs

Active Publication Date: 2021-11-02
HULUNBEIER NORTHEAST FUFENG BIOTECHNOLOGIES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The optimization of the fermentation medium in the process of preparing glutamic acid by fermentation is an important factor to improve the fermentation efficiency. The applicant's previous patented technology "Method for preparing fermentation medium by using glutamic acid fermentation waste cells" has carried out an improvement on the existing medium Improvement and optimization, including 15% sorghum stalk hydrolyzate, 12% cell hydrolyzate, 5% glucose, 1.2% rice bran extract, 1% corn steep liquor, 0.02% shell powder, 0.02% ferrous sulfate heptahydrate, heptahydrate Magnesium sulfate 0.02%, potassium dihydrogen phosphate 0.01%, and the rest is water; this medium reduces the cost, but there are nitrogen and carbon sources with more pigments, high viscosity and many impurities, making the fermentation process difficult to control and easy to Causes the instability of fermentation and the difficulty of separation and extraction; moreover, the patent document uses high-concentration hydrochloric acid in the treatment method of bacterial protein, which is easy to cause damage to amino acids, resulting in low nutritional value of hydrolyzate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] An amino acid fermentation medium, which includes a fermentation medium A and a fermentation medium B, the fermentation medium A and the fermentation medium B are used separately, and the amino acid is glutamic acid;

[0033] The fermentation medium B is to add inositol and glycerol on the basis of the fermentation medium A;

[0034] The fermentation medium A is: glucose 50g / L, Na 2 HPO 4 12H 2 O 2g / L, KCl 1g / L, MgSO 4 ·7H 2 O1g / L, MnSO 4 ·H 2 O 3mg / L, FeSO 4 ·7H 2 O 3mg / L, V B1 10mg / L, 1mg / L fulvic acid, 7μg / L biotin, 60ml / L enzymatic hydrolyzate, sterilized at 115°C for 15min;

[0035] The fermentation medium B is: glucose 50g / L, Na 2 HPO 4 12H 2 O 2g / L, KCl 1g / L, MgSO 4 ·7H2 O1g / L, MnSO 4 ·H 2 O 3mg / L, FeSO 4 ·7H 2 O 3mg / L, V B1 10mg / L, 1mg / L fulvic acid, 7μg / L biotin, 60ml / L cell enzymolysis solution, 100mg / L inositol, 500mg / L glycerin, sterilized at 115°C for 15min;

[0036] The preparation method of the thallus enzymatic solution is as follows: ...

Embodiment 2

[0039] The green production technique of glutamic acid, it comprises the steps:

[0040] 1) Brevibacterium flavum GDK-9 (sourced from Tianjin University of Science and Technology, the source of the strain can also refer to "Study on the variable temperature control process of L-glutamic acid fermentation, Tianjin Chemical Industry, 2010") was inoculated with 12% seed solution (OD 600nm 10) Connect to a 50L automatic fermenter equipped with 30L fermentation medium A for fermentation and cultivation, the fermentation temperature is 38°C, the ventilation ratio is 1:0.7, the stirring speed is 500r / min, and the dissolved oxygen is maintained at 20%. Coupled with the ceramic membrane, when the fermentation reaches 24 hours, the fermentation liquid A in the fermenter is separated through the ceramic membrane to obtain the filtrate A and the concentrated bacteria, the filtrate A is discharged, the concentrated bacteria are returned to the fermenter, and at the same time, the fermenter ...

Embodiment 3

[0044] Influence of hydrolysis process on bacterial proteolysis components:

[0045] Set up a control group,

[0046] Matched group 1: do not adopt high-speed shearing machine to process, all the other are the same as embodiment 1;

[0047] Control group 2: Hydrochloric acid with a concentration of 5 mol / L was used for hydrolysis for 6 hours.

[0048] The wall breaking rate, protein content and total free amino acid content are shown in Table 1:

[0049] group Example 1 Control group 1 Control group 2 Broken rate% 97.2 83.4 68.7 Protein content mg / g (dried bacteria) 226.1 285.9 268.5 Total free amino acid content mg / g (dried bacteria) 371.5 256.3 187.4

[0050] Visible by table 1, utilize high-speed shearing machine to shear and process 120s, can greatly improve cell wall breaking rate, thereby improve hydrolysis efficiency; The present invention adopts dilute hydrochloric acid to carry out pretreatment, and used acid concentration ...

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Abstract

The invention belongs to the technical field of amino acids, and discloses a green production process of glutamic acid, which comprises the following steps: step 1) fermentation, step 2) ultrafiltration, step 3) concentration, and step 4) isoelectricity. The process of the invention has high fermentation efficiency, simple separation and extraction, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of amino acid production and relates to a green production process of glutamic acid. Background technique [0002] Corynebacterium glutamicum is a strain of glutamic acid fermentation, which belongs to facultative aerobic bacteria. The culture medium composition and culture conditions are different, and the products are also different. In the process of glutamic acid fermentation, when the carbon-nitrogen ratio in the medium changes, it will affect the strain proliferation and glutamic acid synthesis. When the pH of the fermentation broth is acidic, the glutamic acid produced is further converted to acetylglutamine. Therefore, the optimization of glutamic acid fermentation conditions mainly consists of two aspects: medium composition and fermentation process parameter control optimization. During the fermentation process, the fermentation characteristics of the strain itself sometimes change, resulting in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P13/14C12R1/13
CPCC12P13/14
Inventor 赵兰坤李德衡徐庆阳马延和刘元涛许传高张婷婷
Owner HULUNBEIER NORTHEAST FUFENG BIOTECHNOLOGIES CO LTD