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Magnetic composite nanomaterial and preparation method and application thereof

A magnetic composite nano-material technology, applied in the field of mesoporous core-shell composite nano-materials and its preparation, can solve the problems of low longitudinal relaxation rate, transverse and longitudinal relaxation rate ratio, etc.

Inactive Publication Date: 2019-03-29
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, common iron oxide nanoparticles are not suitable as MRI T1 contrast agents: MRI T1 contrast agents should have a high longitudinal relaxation rate (r1) and a low transverse-to-longitudinal relaxation rate ratio (r2 / r1≤3) , to highlight the MRI T1 contrast effect (maximized)

Method used

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  • Magnetic composite nanomaterial and preparation method and application thereof
  • Magnetic composite nanomaterial and preparation method and application thereof
  • Magnetic composite nanomaterial and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] Example 1 Sample 1 # Preparation

[0149] (1) Weigh 1g of NaOH into a 100ml beaker, add 10ml of oleic acid and 10ml of ethanol to it, and stir on a magnetic stirrer until the NaOH is evenly dissolved and dispersed to obtain solution a;

[0150] (2) Weigh 1.73mM Fe 2+ Salt and 0.267mM Zn 2+ Salt, dissolved in 20ml of ultrapure water, and sonicated until all the salt is dissolved and mixed uniformly to obtain solution b;

[0151] (3) At room temperature, the above solution b is added dropwise to solution a, and magnetically stirred until the solution turns brown and clear to obtain solution c;

[0152] (4) Take 30ml c solution and transfer it to the polytetrafluoroethylene liner, and put it in the reaction kettle for sealing, put the reaction kettle in the oven, and react at 230℃ for 20 hours;

[0153] (5) After the reaction is completed, the reactor is cooled to room temperature, the nanoparticles at the bottom of the polytetrafluoroethylene liner are dissolved in chloroform and t...

Embodiment 2

[0156] Example 2 Sample 2 # Preparation

[0157] (1) Weigh 1g of NaOH into a 100ml beaker, add 10ml of oleic acid and 10ml of ethanol to it, and stir on a magnetic stirrer until the NaOH is evenly dissolved and dispersed to obtain solution a;

[0158] (2) Weigh 1.73mM Fe 2+ Salt and 0.534mM Zn 2+ Salt, dissolved in 20ml of ultrapure water, and sonicated until all the salt is dissolved and mixed uniformly to obtain solution b;

[0159] (3) At room temperature, the above solution b is added dropwise to solution a, and magnetically stirred until the solution turns brown and clear to obtain solution c;

[0160] (4) Transfer 30ml of solution c to a polytetrafluoroethylene liner, and put it in the reactor for sealing, put the reactor in an oven, and react at 230°C for 20 hours;

[0161] (5) After the reaction is completed, the reactor is cooled to room temperature, the nanoparticles at the bottom of the polytetrafluoroethylene liner are dissolved in chloroform and taken out into a 50ml centri...

Embodiment 3

[0164] Example 3 Sample 3 # Preparation

[0165] (1) Weigh 1g of NaOH into a 100ml beaker, add 10ml of oleic acid and 10ml of ethanol to it, and stir on a magnetic stirrer until the NaOH is evenly dissolved and dispersed to obtain solution a;

[0166] (2) Weigh 1.73mM Fe 2+ Salt and 0.801mM Zn 2+ Salt, dissolved in 20ml of ultrapure water, and sonicated until all the salt is dissolved and mixed uniformly to obtain solution b;

[0167] (3) At room temperature, the above solution b is added dropwise to solution a, and magnetically stirred until the solution turns brown and clear to obtain solution c;

[0168] (4) Transfer 30ml of solution c to a polytetrafluoroethylene liner, and put it in the reactor for sealing, put the reactor in an oven, and react at 230°C for 20 hours;

[0169] (5) After the reaction is completed, the reactor is cooled to room temperature, the nanoparticles at the bottom of the polytetrafluoroethylene liner are dissolved in chloroform and taken out into a 50ml centri...

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Abstract

The invention relates to a magnetic composite nanomaterial and a preparation method and application of the magnetic composite nanomaterial. In particular, the invention discloses a nanocomposite taking a metal-doped ferrite material as a core and an acid-responsive mesoporous material as a shell. The magnetic nanocomposite can enhance the MRI T1 weighted imaging effect based on magnetic resonanceharmonic theories. The magnetic nanocomposite is applied to magnetic resonance imaging, thereby being capable of obtaining a high-quality MRI contrast agent with obviously excellent imaging performances, high acid sensitivity and rich T1 signals, so that the identification and detection of serious diseases such as tumors can be improved by the contrast agent to obviously reduce errors in medical image detection and treatment costs.

Description

Technical field [0001] The invention relates to the field of materials, in particular to a mesoporous core-shell composite nano material and a preparation method and application thereof. Background technique [0002] The tumor microenvironment is the internal environment in which the tumor is located, the "soil" on which tumor cells depend for survival, and plays a vital role in the occurrence and progression of tumors. The tumor microenvironment is mainly composed of stromal cells, capillaries, extracellular matrix, related cytokines, hormones, and a small amount of infiltrating cells. It is a complex and comprehensive system. The various factors work together to regulate tumor proliferation, invasion, migration, and adhesion. Attachment, angiogenesis and other processes. [0003] Oxygen molecule is an essential component for maintaining biological energy in cells during aerobic metabolism, and can act as electron acceptor in many organic and inorganic reactions in the body. Abn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K47/04A61K47/02
CPCA61K47/02A61K49/183
Inventor 吴爱国马园园陈天翔杨方
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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