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Titanium alloy artificial joint with biolubricating surface layer and preparation method thereof

A technology of artificial joints and titanium alloys, applied in coatings, tissue regeneration, medical science, etc., can solve problems affecting quality and service life, high wear debris, adverse physiological reactions, etc.

Active Publication Date: 2021-07-06
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, titanium alloys produce high wear and a large amount of wear debris during the sliding friction process. The accumulation of wear debris leads to macrophage phagocytosis, induces adverse physiological reactions, releases a large amount of osteolytic factors, and causes bone resorption by osteoclasts, eventually making the fixation Good artificial joints fail due to aseptic loosening and osteolysis, seriously affecting quality and service life

Method used

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  • Titanium alloy artificial joint with biolubricating surface layer and preparation method thereof

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preparation example Construction

[0038] Titanium alloy artificial joint preparation method with biological lubrication surface, the following steps:

[0039] (1) Preparation of Polyelectrolyte Solution: Futured Polyci Electrolyte Solution and Polyanion Electrolyte Solution;

[0040] (2) The titanium alloy substrate is hydroxylated to form a hydroxylated substrate;

[0041] (3) The layer of self-assembled polyelectrolyte layer includes the following steps:

[0042](3.1) Put the hydroxylated substrate into the polycation electrolyte solution so asit, form a layer of polycation electrolyte layer, remove cleaning and dry;

[0043] (3.2) and then immersed in the polyanionic electrolyte solution to form a layer of polyanion electrolyte layer, remove cleaning and dry;

[0044] (3.3) Repeat step (3.1) and (3.2) in turn, form a multilayer polymer electrolyte layer having an interleaved N-layer polycation electrolyte layer and an N layer polymerionion electrolyte layer;

[0045] Complete the preparation of artificial joint...

Embodiment 1

[0056] 1 # Preparation of titanium alloy artificial joints with biological lubrication layers.

[0057] The aqueous 1 mg / ml of polydienyl dimethyl chloride solution, 1 mg / ml of polyacrylic acid solution, and the titanium alloy substrate was treated, and the time was 5 min, and the hydroxylated substrate was obtained; the hydroxylated substrate was immersed. After 5 min in an aqueous polythylene dimethyl ammonium chloride, washing and drying with deionized water, then immersed in aqueous polyacrylic acid aqueous solution of 5 min, removed with deionized water and blowing; in two polyelectrolytes In the solution, it is subjected to 5 times, and a multilayer polymer electrolyte layer having a 5-layer polymerization layer having a 3-layer polymerion-free layer is formed on the titanium alloy substrate. Made 1 # Titanium alloy artificial joint with biological lubrication layers.

Embodiment 2

[0059] 2 # Preparation of titanium alloy artificial joints with biological lubrication layers.

[0060] 2 mg / ml of polymethlamine aqueous solution, 2 mg / ml of polymethyl methacrylic acid solution, 2 mg / ml of polymethyl methacrylic acid solution; Treatment of a Piranha solution of the titanium alloy substrate, 80 ° C water bath, to obtain a hydroxylated substrate; extract the hydroxylated substrate in polyhydrate The aqueous solution of acrylamine was 60 min, and the deionized water was cleaned and dried, and then immersed in aqueous polymethyl methacrylic acid solution for 60 min, and the removed water was washed and blown; in two polyelectrolyte solutions, it was immersed 10 times, respectively. A multilayer polymer electrolyte layer having a 10-layer polymerization layer having a interlaced superimposed layer is formed on the titanium alloy substrate. Made 2 # Titanium alloy artificial joint with biological lubrication.

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Abstract

The invention discloses a titanium alloy artificial joint with a biological lubricating surface layer, which is composed of a titanium alloy base and a biological lubricating surface layer. The biological lubricating surface layer is a polymer electrolyte layer prepared by layer-by-layer self-assembly technology. And the preparation method of the above-mentioned joint, the steps are as follows: (1) preparing a polycation electrolyte solution and a polyanion electrolyte solution; (2) carrying out hydroxylation treatment on the titanium alloy substrate to form a hydroxylation substrate; (3) self-assembling polyelectrolyte layer by layer layer, formed as the bio-lubricating surface layer; and the preparation of the titanium alloy artificial joint is completed. The artificial joint has a good lubricating effect, can effectively reduce wear debris, improve tribological properties, achieve the effect of inhibiting osteolysis and aseptic loosening, and effectively prolong the service life of the artificial joint.

Description

Technical field [0001] The present invention relates to a titanium alloy artificial joint with a biological lubricating surface, and a method of preparation thereof, in particular, to the artificial joint of good lubricating efficacy and its preparation method thereof, in particular to friction wear. Background technique [0002] Titanium alloys, due to excellent mechanical properties, anti-fatigue strength, biocompatibility, etc., are widely used in artificial joint materials. However, the titanium alloy produces higher wear and large amounts of friarging during the sliding friction, and the abrasive concentration leads to a poor physiological response of macrophage phagocytosis, releases a large amount of lyson factor, resulting in bone absorption of osteoblasts, and ultimately Good artificial joints fail due to sterile loosening and osteophenol, seriously affect quality and service life. Therefore, improve the lubrication of the replacement joint in the body environment, exten...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/56
CPCA61L27/06A61L27/34A61L27/56A61L2300/452A61L2300/608A61L2420/08A61L2430/24
Inventor 邓亚玲孙见君于波熊党生
Owner NANJING FORESTRY UNIV
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