Preparation process for high-stability prinsepia utilis royle liposome and application of high-stability prinsepia utilis royle liposome in cosmetics

A technology for the preparation of oily liposomes, which is applied in the field of carrier systems, can solve the problems of uneven particle size distribution of liposomes, low encapsulation efficiency of active substances, general stability, etc., so as to improve bioavailability, improve encapsulation The sealing rate and stability, and the effect of promoting human body absorption

Inactive Publication Date: 2019-04-09
YUNNAN BOTANEE BIO TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The commonly used preparation methods of liposomes include ethanol injection method, vortex dispersion method, ultrasonic dispersion method, and reverse phase evaporation method. These methods often involve the addition and evaporation of organic solvents, and the process is relatively complicated. The obtained liposome particles The diameter distribution is uneven, the stability is average, and the encapsulation efficiency of the active substance is not high, and there is a problem of drug leakage

Method used

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  • Preparation process for high-stability prinsepia utilis royle liposome and application of high-stability prinsepia utilis royle liposome in cosmetics
  • Preparation process for high-stability prinsepia utilis royle liposome and application of high-stability prinsepia utilis royle liposome in cosmetics
  • Preparation process for high-stability prinsepia utilis royle liposome and application of high-stability prinsepia utilis royle liposome in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] see figure 1 with figure 2 , a kind of preparation technology of highly stable thorn fruit oil liposome, comprises the following steps:

[0035]S1, 14 parts of lecithin, 55 parts of glycerol (stabilizer) and 1 part of cholesterol (stabilizer) were added to the container respectively, and the eggs were stirred at 70°C and 200 rpm / min. Phospholipids, glycerol and cholesterol are mixed and dissolved evenly;

[0036] S2, adding 9 parts of green thorn fruit oil to the mixed solution obtained in step S1, and stirring evenly under the temperature condition of 60° C. and the stirring condition of 200 rpm / min to obtain the oil phase;

[0037] S3, heating 21 parts of deionized water to 70°C to obtain an aqueous phase;

[0038] S4, inject the oil phase obtained in step S2 into the water phase obtained in step S3, and shear at a shear rate of 5000 rpm / min at a temperature of 70°C and a stirring condition of 200 rpm / min to obtain a semi-transparent and viscous Liposome colostru...

Embodiment 2

[0042] see figure 1 and figure 2 , a kind of preparation technology of highly stable thorn fruit oil liposome, comprises the following steps:

[0043] S1, add 12 parts of lecithin, 12 parts of sorbitol (stabilizer), 26 parts of glycerol (stabilizer) and 1 part of polyglycerol 10-stearate (nonionic surfactant) In the container, mix and dissolve lecithin, sorbitol, glycerol and polyglycerol 10-stearate evenly under the temperature condition of 65° C. and the stirring condition of 200 rpm / min;

[0044] S2, adding 15 parts of thorn fruit oil to the mixed solution obtained in step S1, and stirring evenly under the temperature condition of 70° C. and the stirring condition of 200 rpm / min to obtain the oil phase;

[0045] S3, heating 34 parts of deionized water to 70°C to obtain an aqueous phase;

[0046] S4, inject the oil phase obtained in step S2 into the water phase obtained in step S3, and shear at a shear rate of 5000 rpm / min at a temperature of 70°C and a stirring conditio...

Embodiment 3

[0050] see figure 1 and figure 2 , a kind of preparation technology of highly stable thorn fruit oil liposome, comprises the following steps:

[0051] S1, 6 parts of lecithin, 30.5 parts of pentaerythritol (stabilizer), 1 part of phytosphingosine (stabilizer), 20 parts of butanediol (stabilizer) and 0.5 parts of Span 60 (nonionic Surfactants) were added in the container respectively, and the lecithin, pentaerythritol, phytosphingosine, butanediol and Span 60 were mixed and dissolved evenly under the temperature condition of 65° C. and the stirring condition of 200 rpm / min;

[0052] S2, adding 5 parts of green thorn fruit oil to the mixed solution obtained in step S1, stirring evenly at a temperature of 70°C and a stirring condition of 200rpm / min to obtain an oil phase;

[0053] S3, heating 37 parts of deionized water to 70°C to obtain an aqueous phase;

[0054] S4, inject the oil phase obtained in step S2 into the water phase obtained in step S3, and shear at a shear rate ...

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Abstract

The invention discloses a preparation process for a high-stability prinsepia utilis royle liposome. The prinsepia utilis royle liposome is prepared by adopting a high and low temperature alternating and high pressure homogenizing compound process, so that the problems about stability, encapsulation rate, slow-release effect, convenience in adding to water and the like of rinsepia utilis royle oilcan be solved; the encapsulation rate of the rinsepia utilis royle oil is effectively improved, and the encapsulation rate is greater than 98 percent. The active matter, namely, the rinsepia utilis royle oil, which is covered effectively is low in loss and high in stability. The prinsepia utilis royle liposome is not added with any organic solvents and additives with toxic and/or side effects, andcan be directly used as green and safe cosmetics. The prinsepia utilis royle liposome is nano-scale; the bioavailability is improved; the prinsepia utilis royle liposome can be mutually dissolved inwater in any ratio, so that the prinsepia utilis royle liposome can be widely applied to preparation of various types of the cosmetics. The invention also discloses the application of the high-stability prinsepia utilis royle liposome in the cosmetics; the high-stability prinsepia utilis royle liposome can make skin moist and smooth, can treat chilblains, and also has an extremely good conditioning effect on hair care.

Description

technical field [0001] The invention relates to a preparation process of a highly stable thorn fruit oil liposome and its application in cosmetics, belonging to the technical field of carrier systems in cosmetics preparation technology. Background technique [0002] Green thorn fruit is a perennial shrub of the genus Rosaceae, and its scientific name is Sclerophyllum chinensis. Green thorn fruit has a long history and a wide range of uses in food, skin care, beauty and traditional Chinese medicine. [0003] Modern studies have shown that green thorn fruit oil contains three types of fatty acids that are very important to human health, including saturated fatty acids (palmitic acid and stearic acid), monounsaturated fatty acids (oleic acid) and polyunsaturated fatty acids (linoleic acid and Linolenic acid) content composition ratio is (0.6~0.7):1:1, so the oil is a good natural nutritional edible blending oil, regular consumption can reduce blood lipids, regulate blood press...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/14A61Q19/00A61Q5/00A61K36/73A61P17/10A61P17/02
CPCA61K8/14A61K8/922A61K36/73A61K2800/10A61Q5/002A61Q19/00A61P17/02A61P17/10
Inventor 王飞飞苏温柔程党党马骁郭振宇何黎
Owner YUNNAN BOTANEE BIO TECH GRP CO LTD
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