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A kind of microporosa haemophilus extract and its extraction method and application

A technology of dense porosity and dense porosity, applied in application, food extraction, drug combination, etc., can solve problems such as toxic and side effects, and achieve the effects of low production cost, simple process, and pollution avoidance

Active Publication Date: 2021-08-03
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs in these commonly used regimens have obvious toxic and side effects, so how to find a cure for IBD from natural and synthetic compounds is still a long way to go
However, there are no related researches and reports on obtaining the extract of Microporosa haemophilus for treating inflammatory bowel disease through simple and environment-friendly reagents.

Method used

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  • A kind of microporosa haemophilus extract and its extraction method and application
  • A kind of microporosa haemophilus extract and its extraction method and application
  • A kind of microporosa haemophilus extract and its extraction method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of the polysaccharide extract of embodiment 1 Microporosa haemorrhoids

[0028] (1) Get the fruiting bodies of D. sanguineum, pulverize (25000r / min, 5s) through a pulverizer, and use a pore size of 4 mesh (65 μm) to 50 mesh (355 μm) pharmacopoeia inspection sieve to screen, and collect the filtrate (which can pass through 4 mesh sieve, but cannot pass through the 50 mesh sieve, the same below), add it to 5 times the weight of water, soak for 4 hours, heat and extract for 2 hours, filter, and collect the filtrate; repeat the above steps twice, combine the obtained filtrate, and depressurize at 60°C Concentrate to 2 times of the weight of the fruiting body powder of Pycnophora haemorrhoids to obtain a concentrated solution;

[0029] (2) Add dehydrated ethanol to the concentrated solution obtained in step (1) so that the volume fraction of dehydrated alcohol is 70%, let it stand overnight, take the precipitate and dissolve it in water, make its volume equal...

Embodiment 2

[0030] The preparation of the polysaccharide extract of embodiment 2 Microporosa hemoglobin

[0031] (1) Take the fruiting body of D. sanguineum, grind it into powder (25000r / min, 5s) in a pulverizer, use a pharmacopoeia test sieve with an aperture of 4 mesh (65 μm) to 50 mesh (355 μm) to screen, and collect the filtrate; add 15 Soak in twice the weight of water for 4 hours, heat and extract for 2 hours, filter, and collect the filtrate; repeat the above steps once, combine the obtained filtrate, concentrate under reduced pressure at 60°C to 1 times the weight of the fruiting body powder of D.

[0032] (2) Add dehydrated ethanol to the concentrated solution obtained in step (1), so that the volume fraction of dehydrated alcohol is 80%, let it stand overnight, take the precipitate and add water to dissolve, make its volume equal to the volume of the concentrated solution, repeat the above steps 2 times, the finally obtained precipitate was dissolved by adding an appropriate amo...

Embodiment 3

[0033] The preparation of embodiment 3 Microporosa haemorrhoids ethanol extract

[0034] Take the fruiting body of D. haemorrhoids, grind it into powder (25000r / min, 5s) in a pulverizer, use a pharmacopoeia inspection sieve with a pore size of 4 mesh (65 μm) to 50 mesh (355 μm) to screen, collect the filtrate, and add to 30 times the weight In an ethanol aqueous solution with a volume fraction of 60%, heat and reflux at 80°C for 2 hours, filter, collect the filtrate, repeat the above heating and reflux operation twice for the filter residue, combine the obtained filtrates for three times, concentrate under reduced pressure at 50°C until there is no ethanol smell, freeze-dry, that is Obtain the ethanol extract of Microporosa haemophilus.

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Abstract

The invention discloses an extract of Mypopora haemorrhoids and its extraction method and application. During the extraction process of the Microporosa sanguinea extract of the present invention, environmental-friendly water and ethanol are used as solvents, and extraction and purification are carried out by heating extraction, freeze drying and other mild means, which has the advantages of simple process, low production cost, and avoiding organic solvent pollution , and the extraction method can maximize the retention of the activity of the extract of Microporosa haemophilus; the extracted polysaccharide extract and ethanol extract of Microporosa haemophilus can be used to prepare drugs for the treatment of inflammatory bowel disease, food for special medical purposes, and functional food Or health products, which can not only inhibit the inflammatory response of inflammatory bowel disease, but also promote the repair of colon tissue, and have a good application prospect.

Description

Technical field: [0001] The invention belongs to the field of medicine and health care, and more specifically, the invention relates to an extract of Microporia haemorrhoids that can relieve inflammatory bowel disease, an extraction method and application thereof. Background technique: [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a chronic intestinal immune disease of unknown etiology, including ulcerative colitis (Ulcerative Colitis, UC) and Crohn's disease (Crohn's Disease, DC). Europe and the United States have always been high-incidence areas of IBD; although the incidence in Asia, such as China, South Korea, and Japan, is relatively low, it has shown a clear upward trend in recent years. The incidence of IBD in young and middle-aged people is significantly higher than that of other age groups, and it often presents an attack-remission-relapse pattern. Therefore, the cost of treatment is huge, and even in the late stage of the disease, the les...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K36/07A61P1/00A23L33/10A23L31/00
CPCA23V2002/00A61K31/715A61K36/07A61K2236/331A61K2236/53A23L31/00A23L33/10A61P1/00A23V2200/32A23V2250/208A23V2300/14
Inventor 苏冀彦李木霞李丹陈小红李文治谢意珍吴清平陈少丹张一帆黄龙花
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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