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Controllable biodegradable copolymer material and preparation method and application thereof

A biodegradable and copolymer technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of material elongation at break, material tensile strength decrease, slow biodegradation, poor hydrophilicity of copolymer, etc. High expansion ratio, high mechanical strength, and the effect of improving mechanical properties

Inactive Publication Date: 2019-04-19
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the copolymerized modified materials disclosed in the above invention generally have a shortcoming, that is, while improving the elongation at break of the material, it will cause a decrease in the tensile strength of the material.
[0005] Studies have shown that the two optical isomers of polylactic acid, the left-handed and the right-handed polylactic acid, and their mixture-racemic polylactic acid have a greater impact on its mechanical properties and biodegradability. For example, the patent CN100462387C mentioned that Lactide-caprolactone copolymer and different ratios of L- / D-lactide-caprolactone copolymers have a large gap in degradation cycle and mechanical properties, but the copolymer is poorly hydrophilic, making it biodegradable very slowly

Method used

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  • Controllable biodegradable copolymer material and preparation method and application thereof
  • Controllable biodegradable copolymer material and preparation method and application thereof
  • Controllable biodegradable copolymer material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 5-9 3

[0044] Copolymer P(LA-co-CL-co-TMC) of embodiment 5-9 trimethylene carbonate

[0045] Table 2 embodiment 9-12 formula and reaction condition thereof

[0046]

[0047] Preparation method: Mix trimethylene carbonate, L-, D-lactide, and caprolactone and add them to the reactor. After mixing, repeatedly vacuumize and fill with nitrogen for 20 times; add to the reactor under nitrogen atmosphere Ring-opening polymerization catalyst, heating the reactor to the corresponding temperature, and reacting for a certain period of time; cooling the reactor, adding it into dichloromethane for dissolution, and then precipitating in absolute ethanol, and drying the precipitated product.

Embodiment 10

[0052] The tensile property research of embodiment 10 copolymers

[0053] Table 3 copolymer performance and its tensile performance comparison

[0054]

[0055] Lactide L / D in the above table refers to the feed ratio when L-lactide and D-lactide are polymerized

[0056] The detection of polymer intrinsic viscosity is based on GB / T 1632.1-2008 plastics using a capillary viscometer to measure the viscosity of dilute polymer solutions. Part: The test conditions for thin plastics and thin sheets are carried out. Dispersion is determined by GPC.

[0057] As can be seen from Table 3, in the 4 kinds of copolymers provided by the present invention, adding multi-arm copolymerization center and trimethylene carbonate compared with the non-added copolymer (comparative example 1-2), tensile strength and elongation at break are both increased, indicating that the copolymer provided by the present invention has high mechanical strength and strong flexibility.

Embodiment 11

[0058] The degradation cycle research of embodiment 11 copolymer

[0059] Table 4 trimethylene carbonate copolymer and its performance comparison

[0060]

[0061] Note: Degradation test is carried out according to YY / T 0473-2004 Surgical implant polylactide copolymer and blend in vitro degradation test

[0062] It can be seen from Table 4 that the degradation period of the copolymer containing multi-arm center and trimethylene carbonate can be shortened by 6 weeks and 7 weeks respectively than that of the copolymer not containing trimethylene carbonate. In the process, it can avoid the swelling caused by the copolymer not degrading for a long time in the body, which will damage human health. The degradation time of the two copolymers can be adjusted by adjusting the ratio of caprolactone and trimethylene carbonate, so as to meet different clinical requirements for degradation time in various fields of application.

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Abstract

The invention provides a controllable biodegradable copolymer material and a preparation method and application thereof. The controllable biodegradable copolymer material is prepared from A, B and C,A refers to levolactides, dextral lactides or lactides with different L / D values, B refers to caprolactone, and C refers to multi-arm polymerization center or trimethylene carbonate. The two providedbiodegradable copolymers have excellent mechanical strength and flexibility, and can be widely used in the field of tissue engineering as carriers or devices, especially in the preparation of nerve conduits.

Description

technical field [0001] The invention belongs to the field of polymer materials, and relates to a controllable biodegradable copolymer material, a preparation method and its application, and its application in the preparation of carriers or devices used in the field of tissue engineering. Background technique [0002] According to the source, biodegradable polymers can be divided into two categories: natural and synthetic. Natural degradable polymers include chitosan, chitin and their derivatives, etc.; synthetic degradable polymers are divided into two categories: artificial synthesis and bacterial synthesis. . Degradable polymers synthesized by bacteria include polyhydroxyalkanol esters and polyB 2 Glucose esters, etc., synthetic degradable polymers include aliphatic polyesters, polyamino acids, and polyphosphazenes, among which polyesters are currently the only type of biodegradable materials approved by the US FDA for use in the biomedical field. The more commonly used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08G63/64A61L27/58A61L27/18A61L27/50A61L31/14A61L31/06
CPCA61L27/18A61L27/507A61L27/58A61L31/06A61L31/148A61L2430/32C08G63/08C08G63/64C08L67/04
Inventor 张旗黄凤洪陶秀梅尚丽霞陈鹏汤虎张浩
Owner NKD PHARMA CO LTD
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