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Flueconazole aqueous suspension and preparation method thereof

A technology of epoxiconazole water and suspending agent, which is applied in the fields of botanical equipment and methods, fungicides, biocides, etc., can solve the problems of poor stability, more foam, poor automatic dispersion, etc., and achieves low mobility, easy processing, The effect of increasing stability

Active Publication Date: 2021-07-09
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] For above-mentioned deficiencies in the prior art, the first object of the present invention is to provide a kind of epoxiconazole aqueous suspension concentrate, the second object of the present invention is to provide the preparation method of this kind epoxiconazole aqueous suspension concentrate, significantly reduce the suspension processing Problems such as poor heat (cold) storage stability, more foam, poor automatic dispersibility and Austenitic aging

Method used

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  • Flueconazole aqueous suspension and preparation method thereof
  • Flueconazole aqueous suspension and preparation method thereof

Examples

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Effect test

Embodiment 110

[0029] Example 1 Preparation of 10% epoxiconazole aqueous suspension

[0030] The content of each component (by weight) is 10% of the original drug of epoxiconazole, 3% of tristyrylphenol polyoxyethylene ether sulfate dispersant (Shanghai Shida Polymer Material Co., Ltd.), polymer EO-PO block Copolymer dispersant 1% (Shanghai Shida Polymer Material Co., Ltd.), thickener xanthan gum XG (2%) 3%, defoamer silicone 0.5%, ethylene glycol 3% (Aladdin Reagent Shanghai Co., Ltd. company), adjust the pH value to 7-8 with triethanolamine. Add deionized water to l00%.

[0031] In the first step, add tristyrylphenol polyoxyethylene ether sulfate dispersant, polymer EO-PO block copolymer dispersant, ethylene glycol, and silicone defoamer to deionized water and mix well, then add fluorine Cycloconazole raw material and zirconia beads of equal quality are sand-milled at a speed of 1200in, the sand-milling temperature is controlled below 40°C, and the sand-milling is stopped after the parti...

Embodiment 2

[0036] Embodiment 2 Preparation of 20% epoxiconazole aqueous suspension

[0037] The content of each component (by weight) is 20% of the original drug of epoxiconazole, 4% of tristyrylphenol polyoxyethylene ether sulfate (Shanghai Shida Polymer Material Co., Ltd.); alkylphenol polyoxyethylene ether 2 %; Thickener sodium carboxymethyl cellulose 4%, defoamer silicone compound 0.5%, antifreeze agent glycerol 4% (Aladdin Reagent Shanghai Co., Ltd.), adjust the pH value to 7-8 with ammonia water. Add deionized water to l00%. The specific preparation is carried out according to Example 1.

[0038] Main technical indicators: the average particle size before thermal storage is 2.62 μm, and after thermal storage is 3.04 μm; both before and after thermal storage are white homogeneous liquid, with a limited content of 20%; before thermal storage, the suspension rate is 96.24%, after thermal storage is 95.13%. It shows that the thermal storage stability is qualified.

[0039] Effectiv...

Embodiment 3

[0040]Embodiment 3 Preparation of 30% epoxiconazole aqueous suspension

[0041] The content of each component (by weight) is 30% of the original drug of epoxiconazole, 5% of tristyrylphenol polyoxyethylene ether sulfate dispersant (Shanghai Shida Polymer Material Co., Ltd.); styrylphenol polyoxypropylene Ether 2% (Shanghai is a large polymer material Co., Ltd.); thickener magnesium aluminum silicate 5%, Cl0-20 saturated fatty acid compound 1%, antifreeze agent polyethylene glycol and ethylene glycol 6% (Aladdin reagent Shanghai Co., Ltd.), adjust the pH value to 7-8 with sodium hydroxide. Add deionized water to l00%. The specific preparation is carried out according to Example 1.

[0042] Main technical indicators: the average particle size before thermal storage is 2.83μm, and after thermal storage is 3.26μm; both before and after thermal storage are white homogeneous liquids, with a limited content of 30%; before thermal storage, the suspension rate is 95.48%, after therma...

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Abstract

The invention discloses an epoxiconazole aqueous suspension and a preparation method thereof, which is composed of the following components in weight percent: 10-30 percent of epoxiconazole, 4-7 percent of a dispersant and a wetting agent, and 3-5 percent of a thickener %, 0.5-1% defoamer, 3-6% antifreeze, adjust the pH value to 5-8, and make up to 100% with water; wherein the dispersant is tristyrylphenol polyoxyethylene ether sulfate dispersant; The wetting agent is selected from NP series nonylphenol polyoxyethylene ethers, AEO series fatty alcohol polyoxyethylene ethers, polymer EO-PO block copolymers, alkylphenol polyoxyethylene ethers, styrylphenol polyoxyethylene ethers, and styrene-based phenol polyoxyethylene ethers. One or a combination of two or more of propylene ethers. Significantly reduce the problems of poor heat (cold) storage stability, high foam, poor automatic dispersibility and Austenitic ripening in the processing of suspension concentrates.

Description

technical field [0001] The invention relates to a broad-spectrum bactericidal preparation, in particular to an epoxiconazole aqueous suspension and a preparation method thereof. Background technique [0002] Epoxiconazole is a systemic triazole fungicide, containing fluorine in its structure, with high activity, low toxicity, wide bactericidal spectrum and long-lasting effect. It can inhibit the synthesis of pathogenic bacteria ergosterol and hinder the formation of bacterial cell walls , and compared with currently known fungicides, it can more effectively inhibit pathogenic fungi. At the same time, it can increase the valtinase activity of crops, lead to the contraction of fungal haustoria, and inhibit the invasion of pathogens. This feature makes it unique among triazole fungicides. [0003] At present, the dosage forms of epoxiconazole sold in the domestic market are mainly emulsifiable concentrates, water dispersible granules, and water suspension concentrates. Becaus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/653A01N25/04A01N25/22A01P3/00A01P1/00
Inventor 任天瑞邱俊云张明倩贺鹏辉韦振力花文东李海徽
Owner SHANGHAI NORMAL UNIVERSITY
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