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Application of ovateleaf knotweed rhizomes in preparing antifungal drugs and synergist thereof

An antifungal drug, the technology of red notoginseng, which is applied in the field of medicine, can solve the problems such as the synergistic effect of antifungal effect of red notoginseng, and achieve the effect of reducing drug concentration

Active Publication Date: 2019-05-03
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But at present, there is no report on the antifungal effect of Panax notoginseng and its synergistic effect at home and abroad.

Method used

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  • Application of ovateleaf knotweed rhizomes in preparing antifungal drugs and synergist thereof
  • Application of ovateleaf knotweed rhizomes in preparing antifungal drugs and synergist thereof
  • Application of ovateleaf knotweed rhizomes in preparing antifungal drugs and synergist thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0019] 1. Material preparation

[0020] 1. Test drug

[0021] Red Panax notoginseng: purchased from Delkang Pharmaceutical Chain Store (the fourth chain store of Huai Ya).

[0022] Fluconazole (FLC): sigma company, lot number 036M4709V.

[0023] Dimethyl sulfoxide: Tianjin Tianli Chemical Reagent Co., Ltd.

[0024] All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0025] 2. Strains

[0026] Strains used, including:

[0027] 1) Sensitive strains: sensitive Candida albicans SC5314, Candida parapsilosis 22019 and Cryptococcus neoformans 32609;

[0028] 2) Drug-resistant strains: drug-resistant Candida albicans 103, drug-resistant Candida tropicalis,...

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Abstract

The invention discloses an application of ovateleaf knotweed rhizomes used for preparing antifungal drugs and a synergist thereof, belongs to the technical field of medicine. In vitro cell experimentsshow that ovateleaf knotweed rhizomes have different degrees of antifungal and even fungicidal effects against drug-resistant Candida albicans 103, susceptible Candida albicans SC5314, Cryptococcus neoformans 32609, natural drug-resistant Candida krusei ATCC 2340, Candida parapsilosis 22019, natural drug-resistant Candida glabrata ATCC 2281 and drug-resistant Candida tropicalis, so that the ovateleaf knotweed rhizomes can be used as an antifungal drug and a synergist thereof. The invention opens up a new use for ovateleaf knotweed rhizomes, uses the ovateleaf knotweed rhizomes for preparing antifungal drugs, and provides a new drug candidate for the treatment of fungal infections.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of red notoginseng in the preparation of antifungal drugs and their synergists. Background technique [0002] Red notoginseng belongs to one of the seven medicines of Qinling Mountains. This medicine is the rhizome of Polygonum suffultum Maxim, the pillar of the Polygonaceae plant. Because its rhizome is nodular and shaped like an abacus, it is named "Abacus Seven". The medicine can astringe and stop bleeding, relieve pain and promote granulation. It is mainly used for bruises, traumatic bleeding, blood in the stool, metrorrhagia, dysentery, rectal prolapse, and can also treat hematemesis, blood metrorrhagia, consumptive blood stasis, red and white dysentery, chronic pharyngitis, overstrain, leucorrhea, etc. [0003] But at present, there is no report on the antifungal effect and synergistic effect of red notoginseng at home and abroad. Contents of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P31/10A61K125/00A61K31/4196
Inventor 刘伟杨曼曼孙宝政王胜正张子悦
Owner SHAANXI UNIV OF SCI & TECH
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