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Flexible strip-shaped pH sensor capable of detecting body fluid in real time, and preparation method thereof

A real-time detection and ph sensor technology, applied in the field of flexible sensors, can solve the problems of lack of flexibility and high price, and achieve the effect of simple materials, small volume and easy availability of materials

Active Publication Date: 2019-05-17
厦门柯迪森科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently commercially available pH sensors all use glass electrodes, which are expensive and not flexible.

Method used

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  • Flexible strip-shaped pH sensor capable of detecting body fluid in real time, and preparation method thereof
  • Flexible strip-shaped pH sensor capable of detecting body fluid in real time, and preparation method thereof
  • Flexible strip-shaped pH sensor capable of detecting body fluid in real time, and preparation method thereof

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preparation example Construction

[0038] The present invention also provides a method for preparing the above-mentioned flexible strip-shaped pH sensor capable of real-time detection of body fluids, comprising the following steps:

[0039] Step 1, preparing the reference electrode 22 and the working electrode 21 on the surface of the flexible substrate 1 .

[0040] Further, the flexible substrate 1 is selected from one or more composites of polyvinyl chloride, polycarbonate, polyethylene terephthalate, polyester, paper, cardboard, ceramics and regenerated silk fibroin thing.

[0041] More preferably, in a preferred embodiment of the present invention, the strip-shaped polyethylene terephthalate (PET) material is selected as the base material, which has excellent physical and mechanical properties in a wide temperature range. Performance, the long-term use temperature can reach 120 ℃, has excellent flexibility, electrical insulation, fatigue resistance, friction resistance and dimensional stability, and the ma...

Embodiment 1

[0073] This embodiment provides a flexible strip-shaped pH sensor that can detect body fluids in real time, which is made according to the following steps:

[0074] (1) Get the wool keratin solution of 5ml 5wt%, add HAuCl under vigorous stirring condition 4 solution, and then add 1M sodium hydroxide solution under constant stirring conditions, adjust the pH value to 12, and then place it at 38°C for 12h. Among them, wool keratin and HAuCl in the reaction solution 4 The mass ratio is 100:1.

[0075] (2) The reaction solution was placed at -80° C. for 48 hours of freeze-drying to obtain gold nanoparticles@wool keratin.

[0076] (3) Carbonization: under an argon atmosphere, the gold nanoparticle@wool keratin was heated to 150° C. at a heating rate of 2° C. / min and maintained for 3 hours. Then the temperature was raised to 350°C at a rate of 5°C / min and kept for 3h, and then the temperature was raised to 700°C at a rate of 5°C / min and kept for 2h. Finally, take it out after co...

Embodiment 2

[0081] This embodiment provides a flexible strip-shaped pH sensor that can detect body fluids in real time. The difference from Embodiment 1 is that:

[0082] In step (1), take 5ml of 5wt% silk fibroin solution as the protein base in the protein base nitrogen-doped carbon / gold nanoparticle composite material.

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Abstract

The invention provides a flexible strip-shaped pH sensor capable of detecting body fluid in real time, and a preparation method thereof, and relates to the field of flexible sensors. According to thepreparation method, a detection electrode component is disposed on a flexible substrate, the detection electrode component comprises a working electrode and a reference electrode, which are disposed side by side and are parallel and not in contact with each other. The both ends of the working electrode and the reference electrode are respectively working areas and electrode connecting areas, the working areas of the working electrode and the reference electrode are located on the same side, the middles of the working electrode and the reference electrode are covered with insulating layers, sothat the respective working areas and electrode connecting areas of the working electrode and the reference electrode are insulated from each other, and the working area of the working electrode is provided with a nitrogen-doped carbon material of load metal nanoparticles sensitive to hydrogen ions. The substrate of the pH sensor is made of a flexible insulating material, thereby having high sensitivity and good flexibility, and is low in cost compared with a glass electrode, furthermore, the preparation conditions are simple, and the conditions are controlled easily.

Description

technical field [0001] The invention relates to the field of flexible sensors, and in particular to a flexible strip-shaped pH sensor capable of real-time detection of body fluids and a preparation method thereof. Background technique [0002] The detection of body fluids plays a huge role in medical diagnosis, in which the acidity and alkalinity (pH value) of body fluids can reflect various biochemical information. For example: wound exudate reflects the degree of wound ulceration, tears reflect lacrimal duct infection, saliva reflects oral hygiene, sweat reflects the physical condition of the human body, and urine reflects kidney disease. And the use of non-invasive bodily fluids such as sweat, saliva, and urine can make diagnosis more comfortable for patients. Therefore, pH sensors for accurate and real-time analysis of body fluids are required. However, currently commercially available pH sensors all use glass electrodes, which are expensive and not flexible. Therefor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416G01N27/30G01N27/327
Inventor 刘向阳安尼如德·帕蒂尔杨丽坤刘强孟照辉马丽芸吴荣辉
Owner 厦门柯迪森科技有限公司
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