Method for purifying cannabidiol from waste reagents

A technology of cannabidiol and tetrahydrocannabinol, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems that restrict the promotion and application of nanofiltration membrane technology, affect the treatment effect, and easily pollute NF membranes, etc. To achieve the effect of improving purity and safety, strong anti-pollution and strong anti-pollution ability

Inactive Publication Date: 2019-05-24
黑龙江阳光工业大麻研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] ②NF membrane is easy to be polluted
The pore size of the nanofiltration membrane is small, and the surface is often negatively charged. The complex components in the slightly polluted water source can easily cause pollutant deposition on the membrane surface, resulting in membrane fouling and affecting the treatment effect.
[0007] ③High operating cost
Most of the imported membranes are used in engineering applications. The price of foreign membrane products is relatively high, and the investment in use is relatively large, which greatly restricts the promotion and application of nanofiltration membrane technology in the drinking water industry.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1. Method for purifying cannabidiol from waste reagents.

[0025] 1) Pretreat the extraction waste liquid (containing a small amount of industrial hemp mosaic leaf residue) in the process of preparing cannabidiol CBD by mixing the extraction waste liquid with the organic solvent n-hexane at a volume ratio of 1:2.5 at a temperature of 20 Extract at ℃ for 60 minutes, then recover the reagent, centrifuge the extract, remove the residue, obtain a pretreatment solution, filter the pretreatment solution through a microfiltration membrane with a pore size of 8 μm, and obtain a filtrate containing tetrahydrocannabinol and cannabidiol ;

[0026] 2) According to the ratio of filtrate and ethanol solution volume ratio of 1:1, add ethanol solution with a volume fraction of 88.00% to the filtrate of step 1), mix evenly, and the mixed solution is filtered through an ultrafiltration membrane with a pore size of 0.01 μm to obtain four The retentate of hydrocannabinol and th...

Embodiment 2

[0029] Embodiment 2. A method for purifying cannabidiol from waste reagents.

[0030] 1) Pretreat the extraction waste liquid (containing a small amount of industrial hemp leaf residue) in the process of preparing cannabidiol CBD. After leaching for 30 minutes, the reagent is recovered, the extract is centrifuged, the residue is removed, and a pretreatment solution is obtained, and the pretreatment solution is filtered through a microfiltration membrane with a pore size of 10 μm to obtain a filtrate containing tetrahydrocannabinol and cannabidiol;

[0031] 2) According to the ratio of filtrate and ethanol solution volume ratio of 1:1, add ethanol solution with a volume fraction of 99.95% to the filtrate of step 1), mix evenly, and the mixed solution is filtered through an ultrafiltration membrane with a pore size of 0.1 μm to obtain four The retentate of hydrocannabinol and the filtrate containing cannabidiol, the retentate is concentrated at a vacuum of 0.10Mpa and a temperat...

Embodiment 3

[0034] Example 3. A method of purifying cannabidiol from waste reagents.

[0035] 1) Pretreat the extraction waste liquid (containing a small amount of industrial hemp leaf residue) in the process of preparing cannabidiol CBD. The method is to mix the extraction waste liquid with the organic solvent petroleum ether according to the volume ratio of 1:3. Extract at ℃ for 40 minutes, then recover the reagent, centrifuge the extract, remove the residue, and obtain a pretreatment solution, filter the pretreatment solution through a microfiltration membrane with a pore size of 8.5 μm, and obtain tetrahydrocannabinol and cannabidiol filtrate;

[0036] 2) According to the ratio of filtrate and ethanol solution volume ratio of 1:1, add a volume fraction of 90% ethanol solution to the filtrate of step 1), mix evenly, and the mixed solution is filtered through an ultrafiltration membrane with a pore size of 0.055 μm to obtain four The retentate of hydrocannabinol and the filtrate contai...

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Abstract

The invention provides a method for purifying cannabidiol from waste reagents, belongs to the technical field of functional substance recycling, and aims to achieve recycling of the cannabidiol in thewaste reagents. The method includes the steps: 1) extracting extracted waste liquid generated in cannabidiol CBD preparation process by organic solvents, and filtering extraction liquid by a micro-filtration membrane; 2) mixing the filter liquid and ethanol solution with volume fraction of 88.00-99.95%, filtering mixed liquid by an ultra-filtration membrane to obtain trapped fluid containing tetrahydrocannabinol and filter liquid containing cannabidiol, and concentrating the trapped fluid to obtain tetrahydrocannabinol extraction cream; 3) mixing the filter liquid containing cannabidiol and ethanol solution with the volume fraction of 65.00-85.00%, filtering mixture by a nano-filtration membrane to obtain trapped fluid containing cannabidiol, and concentrating the trapped fluid to obtaincannabidiol extraction cream. The method can be used for recycling cannabidiol extraction waste liquid.

Description

technical field [0001] The invention belongs to the technical field of recovery of functional substances, and in particular relates to a method for purifying cannabidiol from waste reagents. Background technique [0002] Membrane is a kind of inorganic or polymer porous material with special selective separation function. It can separate the fluid into two parts that are not connected, so that one or several substances can pass through, and other substances can be separated. . Membrane separation technology has been widely used in medicine, water treatment, chemical industry, electronics, food processing and other fields because of its high efficiency, energy saving, environmental protection and molecular level filtration. It has become one of the most important technologies in separation science in this century. An emerging green industrial technology. Membrane separation technology uses a semipermeable membrane as a selective barrier layer. At the molecular level, separa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/82C07C39/23C07D311/80
Inventor 曹亮刘欣黄莉
Owner 黑龙江阳光工业大麻研究院
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