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A preparation method and application of polymethyl methacrylate nanosphere-molecularly imprinted fluorescent material

A technology of polymethyl methacrylate and methyl methacrylate, applied in fluorescence/phosphorescence, material excitation analysis, etc., can solve the problems of limited application and achieve good stability

Active Publication Date: 2021-08-03
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these complex modification processes limit its further application

Method used

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  • A preparation method and application of polymethyl methacrylate nanosphere-molecularly imprinted fluorescent material
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  • A preparation method and application of polymethyl methacrylate nanosphere-molecularly imprinted fluorescent material

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Experimental program
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Embodiment 1

[0038] Step 1. Synthesis of PMMA nanoparticles: prepared by soap-free polymerization method, 5 mL of MMA was added to a 250 mL three-necked flask containing 70 mL of ethanol, stirred for 10 min under nitrogen atmosphere; then, 0.01 g of SDBS was added and reacted for 20 min; Subsequently, 20 mL of 0.1 g of K was added dropwise 2 S 2 o 8 , the temperature was raised to 85°C, stirred and reacted for 3 hours, and a mixed solution was obtained after the reaction; then anhydrous calcium chloride solution equal to the volume of the mixed solution was added to precipitate with 1M saturated anhydrous calcium chloride, and after centrifugation at 8000rmp, a solid product was obtained, which was washed with ethanol and water After washing, dry in a vacuum oven at 55°C for 12 hours to obtain PMMA nanoparticles, which are referred to as PMMANs;

[0039] Step 2, the synthesis of the manganese-doped zinc sulfide quantum dots modified by mercaptopropionic acid:

[0040] 11mmol of ZnSO 4 ...

Embodiment 2

[0045] Synthesis of step 1, PMMA nanoparticles:

[0046] Prepared by soap-free polymerization method, 10mL of MMA was added to a 250mL three-necked flask containing 80mL of ethanol, stirred for 20min under nitrogen atmosphere; then, 0.049g of SDBS was added and reacted for 30min; then, 20mL of 0.26g of MMA was added dropwise K 2 S 2 o 8 , the temperature was raised to 85°C, and the reaction was stirred for 4 hours. After the reaction, an equal volume of 2M saturated anhydrous calcium chloride solution was added for precipitation. After centrifugation at 8000rmp, a solid product was obtained. After washing with ethanol and water, put Dry in a vacuum oven at 55°C for 12 hours to obtain PMMA nanoparticles, which are referred to as PMMANs;

[0047] Step 2, the synthesis of the manganese-doped zinc sulfide quantum dots modified by mercaptopropionic acid:

[0048] 12.5mmol of ZnSO 4 ·7H 2 O and 1 mmol MnCl 2 4H2O was added to 40mL of twice distilled water, stirred for 10min u...

Embodiment 3

[0053] Synthesis of step 1, PMMA nanoparticles

[0054] Prepared by soap-free polymerization method, 15mL of MMA was added to a 250mL three-neck flask containing 90mL of ethanol, stirred for 30min under nitrogen atmosphere; then, 0.08g of SDBS was added and reacted for 30min; then, 15mL of 0.3g of MMA was added dropwise K 2 S 2 o 8 , the temperature was raised to 85°C, and the reaction was stirred for 6 hours; after the reaction, a mixed solution was obtained, and a 3M saturated anhydrous calcium chloride solution equal to the volume of the mixed solution was added for precipitation. After washing with water, dry in a vacuum oven at 55°C for 12 hours to obtain PMMA nanoparticles, which are referred to as PMMANs;

[0055] Step 2. Synthesis of manganese-doped zinc sulfide quantum dots modified by mercaptopropionic acid

[0056] 13mmol of ZnSO 4 ·7H 2 O and 1.5 mmol of MnCl 2 4H 2 O was added to 50 mL of double-distilled water, and stirred under nitrogen atmosphere for 10...

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Abstract

The invention belongs to the technical field of detection material preparation, and relates to a method for preparing a polymethyl methacrylate nanosphere-molecularly imprinted fluorescent material; the steps are as follows: step 1, preparation of polymethyl methacrylate nanospheres; step 2, Synthesis of manganese-doped zinc sulfide quantum dots modified by mercaptopropionic acid; step 3, preparation of new molecularly imprinted fluorescent materials based on polymethyl methacrylate nanospheres; the present invention mainly solves the problem that traditional substrates are difficult to directly generate imprinted fluorescent materials Shortcomings, the successful use of the abundant functional groups on the surface of polymer nanospheres has invented a new type of fluorescent material that does not require any modification of the substrate. The fluorescent material has an obvious core-shell structure that is consistent with the goal of the invention; meanwhile, the present invention Combining the selectivity of molecularly imprinted materials and the fluorescence properties of quantum dots, it has been successfully applied to the efficient detection of sulfadiazine.

Description

technical field [0001] The invention belongs to the technical field of detection material preparation, and specifically refers to the preparation of a polymethyl methacrylate (PMMA) nanosphere-molecularly imprinted fluorescent material and its application in the detection of sulfadiazine in tap water. Background technique [0002] Sulfonamides are artificially synthesized antibacterial drugs, which have the advantages of stable properties, wide distribution, simple preparation and low price, and are widely used in the control of various bacterial infections. Sulfadiazine, as one of the antibacterial drugs of sulfonamides, has inhibitory effects on most Gram-negative bacteria and positive bacteria, and has strong inhibitory effects on Neisseria meningitidis, Pneumococcus pneumoniae and Neisseria gonorrhoeae, etc., and is widely used It is used in the treatment of meningitis, but excessive application can lead to liver damage, urine crystals and joint pain and other hazards. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/26C08L33/12C08K3/30C08K3/08G01N21/64
Inventor 杨文明栾雨王宁伟陆毅柳天舒高治坤倪晓霓
Owner JIANGSU UNIV
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