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Siloxane gel with excellent water-absorbing capacity, and biocompatibility, and preparation method thereof

A silicone gel and biocompatible technology, applied in the field of strongly water-absorbing biocompatible silicone gel and its preparation, can solve the problems of difficult clinical application, lack of biomechanical properties, poor compatibility and the like, and achieve good Effects of biomechanical properties, good biocompatibility and oxygen permeability, good chain flexibility

Inactive Publication Date: 2019-05-31
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these products have a certain strength, do not contain or contain a small amount of water, or are composed of inorganic materials, but the outstanding shortcomings of these materials are poor compatibility with the human body, and second, they do not have good biomechanical properties. application is difficult

Method used

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  • Siloxane gel with excellent water-absorbing capacity, and biocompatibility, and preparation method thereof
  • Siloxane gel with excellent water-absorbing capacity, and biocompatibility, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] A strong water-absorbing biocompatible siloxane gel, comprising the following raw materials in parts by weight: 2000 parts of aminopropylmethyldimethoxysilane (monomer), 400 parts of tetraethoxysilane, and tetramethyl 66 parts of ammonium hydroxide, 1 gram per 1000 parts.

[0023] A method for preparing strong water-absorbing biocompatible silicone gel, including the following steps:

[0024] (1) Weigh the above-mentioned raw materials in order in parts by weight;

[0025] (2) Dissolve aminopropylmethyldimethoxysilane (monomer) in a mixed solvent of methanol and water, add the catalyst tetramethylammonium hydroxide to it, and react with nitrogen for 2 hours at 90°C , Then add the crosslinking agent tetraethoxysilane to it and react at 90℃ for 4 hours, and then distill off the excess catalyst and blocking agent under reduced pressure at a temperature of 100℃, and finally the product at room temperature Place in a vacuum drying oven and dry for 4 hours to obtain a mixture;

[0...

Embodiment 2

[0030] A strong water-absorbing biocompatible siloxane gel, comprising the following raw materials in parts by weight: 2000 parts of aminopropylmethyldimethoxysilane (monomer), 1000 parts of tetraethoxysilane, and tetramethyl 100 parts of ammonium hydroxide is 1 gram per 1000 parts.

[0031] A method for preparing strong water-absorbing biocompatible silicone gel, including the following steps:

[0032] (1) Weigh the above-mentioned raw materials in order in parts by weight;

[0033] (2) Dissolve aminopropylmethyldimethoxysilane (monomer) in a mixed solvent of methanol and water, and add the catalyst tetramethylammonium hydroxide to it, and react with nitrogen for 2 hours at 100℃ After adding the crosslinking agent tetraethoxysilane to it and reacting at 100°C for 5 hours, then under reduced pressure distillation at a temperature of 100°C to remove the excess catalyst and blocking agent, and finally the product at room temperature Place in a vacuum drying oven and dry for 4 hours t...

Embodiment 3

[0039] A strong water-absorbing biocompatible siloxane gel, comprising the following raw materials in parts by weight: 2000 parts of aminopropylmethyldimethoxysilane (monomer), 500 parts of tetraethoxysilane, and tetramethyl 80 parts of ammonium hydroxide, 1 gram per 1000 parts.

[0040] A method for preparing strong water-absorbing biocompatible silicone gel, including the following steps:

[0041] (1) Weigh the above-mentioned raw materials in order in parts by weight;

[0042] (2) Dissolve aminopropylmethyldimethoxysilane (monomer) in a mixed solvent of methanol and water, add the catalyst tetramethylammonium hydroxide to it, and react with nitrogen for 2 hours at 90°C , Then add the crosslinking agent tetraethoxysilane to it and react at 90℃ for 4 hours, and then distill off the excess catalyst and blocking agent under reduced pressure at a temperature of 100℃, and finally the product at room temperature Place in a vacuum drying oven and dry for 4 hours to obtain a mixture;

[0...

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Abstract

The invention discloses a siloxane gel with excellent water-absorbing capacity, and biocompatibility. The siloxane gel with excellent water-absorbing capacity, and biocompatibility comprises aminopropyl-methyl-dimeththoxysilane (monomer), tetraethoxysilane, and tetramethylammonium hydroxide. According to the preparation method, aminopropyl-methyl-dimeththoxysilane (DMMPA), and tetraethoxysilane (TEOS) are taken main raw materials, the prepared material possesses excellent biocompatibility and oxygen permeable performance, and excellent biological mechanical properties. Compared with conventional bio-medical materials, the siloxane material possesses excellent chain flexibility; in addition, the siloxane groups are large in bond energy and excellent in oxygen permeable performance, and theoxygen permeable performance is almost 70 times of that of poly hydroxyethyl methacrylate (PHEMA); and after modification, the siloxane polymer is provided with excellent water absorbing capacity.

Description

Technical field [0001] The invention relates to the technical field of biological materials, in particular to a strong water-absorbing biocompatible silicone gel and a preparation method thereof. Background technique [0002] With the improvement of living standards and the improvement of medical conditions, mankind has put forward higher requirements for the performance of biomedical materials, and people are paying more and more attention to the comprehensive performance of materials instead of just the improvement of strength. Good medical implant materials in the biomedical field need to have biocompatibility, stability and mechanical properties. Today, a variety of artificial tissues or organs have been successfully developed, and some have been used in clinical treatments, such as: artificial heart valves modified with biological valves, artificial blood vessels made of polymer fibers, and acrylic silicone Contact lenses and artificial cartilage prepared by polymerization ...

Claims

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Application Information

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IPC IPC(8): C08G77/26C08G77/08C08G77/06C08J3/075C08L83/08
Inventor 夏琳陈帅符文鑫邱桂学
Owner QINGDAO UNIV OF SCI & TECH