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Anticancer drug complex, and preparation method and application thereof

A technology of anti-cancer drugs and complexes, applied in the biological field, can solve the problems of reduced curative effect of chemotherapy drugs, multi-drug resistance of tumors, and multiple targets, and achieve the goal of enhancing targeting performance, good reproducibility, and reducing toxic and side effects Effect

Active Publication Date: 2019-06-04
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But these drugs are often multi-targeted and have significant side effects
In addition, long-term use of antineoplastic drugs will also cause multidrug resistance of tumors, and the efficacy of chemotherapy drugs will be reduced or invalid.

Method used

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  • Anticancer drug complex, and preparation method and application thereof
  • Anticancer drug complex, and preparation method and application thereof
  • Anticancer drug complex, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Follow the steps below to synthesize anticancer drug complexes

[0047] According to the molar ratio of 1:2:0.001, zinc acetate dihydrate, 2-imidazole formaldehyde and doxorubicin were successively weighed and placed in a dry hammer bottle, dissolved in an equal volume of N,N-dimethylformamide to prepare Solution, wherein the concentration of zinc acetate dihydrate is 0.2 moles per liter. After the dissolution is completed, take 2 milliliters and mix each, avoid light, and shake at room temperature at 100rpm on a shaker for 1h. After centrifuging to remove the supernatant, the product is vacuum-dried. ZIF-90@doxorubicin.

[0048] Weigh [Arg 6 ,Pro 34 ]pNPY and ZIF-90@doxorubicin were placed in a dry Erlenmeyer flask, then an equal volume of methanol was added, ultrasonicated to form a transparent solution, mixed and stirred in the dark for 48 hours, and the mixed solution of methanol and ethanol with a volume ratio of 20:1 was used to High-speed centrifugal washing, ...

Embodiment 2

[0050] Follow the steps below to synthesize anticancer drug complexes

[0051] According to the molar ratio of 1:1:0.005, zinc acetate, 2-imidazole formaldehyde and cisplatin were successively weighed and placed in a dry hammer bottle, dissolved in an equal volume of N,N-dimethylformamide to prepare a solution, wherein , the concentration of zinc acetate is 0.2 moles per liter. After the dissolution is completed, take 2 ml each to mix, avoid light, and shake at room temperature at 100 rpm on a shaker for 1 hour. After the supernatant is removed by centrifugation, the vacuum-dried product is ZIF-90@通 platinum.

[0052] According to the mass ratio of 1:100, weigh [Arg 6 ,Pro 34 ]pNPY and ZIF-90@cisplatin in a dry Erlenmeyer flask, add an equal volume of methanol, sonicate to form a transparent solution, mix and stir for 12 hours in the dark, and use a mixed solution with a volume ratio of methanol and ethanol of 20:1 for ultra-high speed After centrifugal washing and vacuum dr...

Embodiment 3

[0054] Follow the steps below to synthesize anticancer drug complexes

[0055] According to the molar ratio of 1:5:0.05, zinc acetate hexahydrate, 2-imidazole formaldehyde and vincristine were successively weighed and placed in a dry hammer bottle, dissolved in an equal volume of N,N-dimethylformamide to prepare solution, wherein the concentration of zinc acetate hexahydrate is 0.2 moles per liter, after the dissolution is completed, each take 2 milliliters to mix, avoid light, at room temperature, shake at 100rpm on a shaker for 1h, centrifuge to remove the supernatant and then vacuum dry the product. ZIF-90@vincristine.

[0056] Weigh [Phe 6 ,Pro 34 ]pNPY and ZIF-90@vincristine were placed in a dry Erlenmeyer flask, then an equal volume of methanol was added, ultrasonicated to form a transparent solution, mixed and stirred in the dark for 48 hours, and the mixed solution with a volume ratio of methanol and ethanol of 20:1 was used to High-speed centrifugal washing, vacuum...

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Abstract

The invention discloses an anticancer drug complex. The anticancer drug complex has a core-shell structure, wherein a core of the core-shell structure is an anticancer active component, and a shell ofthe core-shell structure is formed by combining at least one of neuropeptide Y or a subtype thereof with a zeolite imidazate skeleton structure material. The invention also discloses a preparation method of the anticancer drug complex, wherein the method comprises the following steps: 1) dissolving a zinc source, 2-imidazolaldehyde and the anticancer active component in a solvent respectively, toobtain three solutions; 2) mixing the three solutions in the step 1 evenly, carrying out centrifugal separation and drying; and 3) dispersing the dried product in the step 2) in a solvent, adding atleast one of neuropeptide Y or the subtype thereof, and carrying out a stirring reaction for 12-72 h. The invention also discloses an application of the anticancer drug complex in preparation of drugsfor cancer treatment, preferably, cancer includes breast cancer with high expression of neuropeptide Y1 receptors and high metastatic breast cancer.

Description

technical field [0001] The application relates to an anticancer drug compound and its preparation method and application, belonging to the field of biotechnology. Background technique [0002] The metal-organic framework structure is a material formed by a metal and an organic substance through a weak coordination bond developed in 1990, and it is also called a "metal sponge". Its various structures provide metal-organic frameworks with different morphologies, compositions, sizes, and chemical properties, and also endow them with multifunctionality and stimuli-responsive drug-controlled release. Organometallic frameworks can still maintain controllable size, shape, and high uniformity while these modifications are performed. In addition, its large specific surface area and high porosity also contribute to the loading capacity of this material. In addition, the weakly coordinated bonds that form the metal-organic framework structure also exhibit biodegradability. In short,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K47/22A61K9/50A61K31/704A61P35/00A61P35/04A61P15/14
Inventor 李娟蒋振奇吴爱国王胤杰袁博房倩兰李彦莹
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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