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A composition, microspheres comprising the composition and preparation method thereof

A technology of composition and microspheres, which is applied in the direction of medical preparations containing active ingredients, drug combinations, microcapsules, etc., can solve the problem of single therapeutic effect, reduce dry mouth and dry mouth complications, high stability, The effect of stimulating saliva secretion

Active Publication Date: 2022-07-26
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned formula can only be used to relieve dry mouth, and cannot take into account dry mouth and complications of dry mouth, such as gingivitis, bad breath and other oral problems at the same time, and the treatment effect is single

Method used

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  • A composition, microspheres comprising the composition and preparation method thereof
  • A composition, microspheres comprising the composition and preparation method thereof

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preparation example Construction

[0031] Wherein, the preparation method of the Ophiopogon japonicus extract is obtained by alcohol extraction from the tuberous roots of the genus Ophiopogon japonicus of Liliaceae. Described alcohol extraction specifically comprises the following steps:

[0032] (1) Clean selection and crushing of raw materials;

[0033] (2) add ethanol, the volume mass ratio of ethanol and raw material is 6-8L / kg, extract more than 1 time, each time 1-2 hours, merge extracting solution, reclaim ethanol, and extracting solution is concentrated;

[0034] (3) Add water with a volume equivalent to 1-2 times the volume of the concentrated solution, stir, stand at room temperature for 12-24 hours and then filter to obtain a filtrate; concentrate and dry to obtain the Ophiopogon japonicus extract.

[0035] The preparation method of the Panax notoginseng extract is as follows: physical crushing of Panax notoginseng pieces into powder, refluxing extraction with 6-10 times water for 3 times, 2-4 hours...

Embodiment 1

[0071] 1. Weigh 1kg of β-glucan, 0.5kg of salivary amylase, 0.2kg of Ophiopogon japonicus extract, 0.1kg of Panax notoginseng extract, dissolve in 10kg of ethanol, stir for 10 minutes, add 2kg of media Porous silica and continued stirring for 2 hours.

[0072] 2. Adopt fluidized bed equipment, set parameter air volume 1050m 3 / h, inlet air temperature 45°C, spray gun pressure 0.26MPa, spray the solution prepared in step 1, after spraying, turn off the spray gun, and dry at 45°C for 20min to obtain microspheres;

[0073] 3. Weigh 0.3kg of Carbopol and disperse it into 20kg of aqueous solution, stir slightly and stand still until completely dissolved, to prepare Carbopol solution.

[0074] 4. Set the fluidized bed parameters and the air volume to 1050m 3 / h, inlet air temperature 45°C, spray gun pressure 0.19MPa, spray the Carbopol solution prepared in step 3 onto the microspheres prepared in step 2, after spraying, turn off the spray gun, dry at 40°C for 30min, then prepare ...

Embodiment 2

[0076] 1. Weigh 0.8kg β-glucan, 0.8kg salivary amylase, 0.1kg Ophiopogon japonicus extract, 0.2kg Panax notoginseng extract, dissolve in 10kg ethanol, stir for 10 minutes, add 1.6kg of mesoporous silica and continued stirring for 2 hours.

[0077] 2. Adopt fluidized bed equipment, set the parameter air volume to 1100m 3 / h, inlet air temperature 45°C, spray gun pressure 0.25MPa, spray the solution prepared in step 1, after spraying, turn off the spray gun, and dry at 45°C for 20 minutes to obtain microspheres;

[0078] 3. Weigh 0.4kg of Carbopol and disperse it into 20kg of aqueous solution, stir slightly and stand still until completely dissolved, to prepare Carbopol solution.

[0079] 4. Set the fluidized bed parameters and the air volume to 950m 3 / h, inlet air temperature 45°C, spray gun pressure 0.2MPa, spray the Carbopol solution prepared in step 3 onto the microspheres prepared in step 2, after spraying, turn off the spray gun, dry at 45°C for 30min, and then prepare ...

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Abstract

The invention belongs to the technical field of oral care products, and discloses a composition, a microsphere containing the composition and a preparation method thereof, and an oral care product containing the microsphere. The composition of the present invention is composed of beta-glucan, salivary amylase, Ophiopogon japonicus extract and Panax notoginseng extract. The composition uses mesoporous silica as a carrier to prepare microspheres carrying the composition. The composition and the microspheres comprising the composition of the present invention have the functions of promoting fluid and fixing gums, and have the functions of stimulating saliva secretion, relieving dry mouth, resisting gingivitis and removing bad breath, and can be used to prepare and reduce dry mouth and complications of dry mouth. The product. Experiments show that the degree of dry mouth of patients with xerostomia is alleviated and the oral comfort is improved after the oral care product prepared by using the microspheres containing the composition of the present invention is compared with the oral care product prepared by using the microspheres not containing the composition of the present invention. There are significant differences compared to oral care products.

Description

technical field [0001] The invention belongs to the technical field of oral care products, in particular to a composition, in particular to a composition with the effect of promoting body fluid and fixing gums, also relates to a microsphere comprising the composition and a preparation method thereof, and further relates to a composition comprising the Microspheres for oral care products. Background technique [0002] Dry mouth is usually caused by decreased salivary secretion from large and small salivary glands, often manifested as thick saliva, mucous membrane burning sensation, abnormal taste, chapped lips, relying on soup to eat, affecting oral functions such as swallowing and language, not only causing a decline in the quality of life of patients , while affecting the patient's social life attitude. The daily saliva secretion of healthy people is about 1 liter, and 99% of saliva is water, in addition to a small amount of protein and electrolytes. Saliva has the functi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/66A61K8/73A61Q11/00A61K38/47A61K9/50A61P1/02A61K36/8968A61K31/716
Inventor 陆海亮黄金莲车飙何益飞肖蕾江山
Owner INFINITUS (CHINA) CO LTD
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