Quercetin metal nano drug and preparation method and application thereof

A technology of metal nano and quercetin, which is applied in the field of anti-tumor drugs to achieve the effects of inhibiting growth, increasing water solubility and stability, and long-term growth

Inactive Publication Date: 2019-06-07
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Quercetin metal nano drug and preparation method and application thereof
  • Quercetin metal nano drug and preparation method and application thereof
  • Quercetin metal nano drug and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0062] Example 1 Synthesis of Quercetin Iron Nanomedicine

[0063] Under 35KHZ 40W ultrasonic conditions, dissolve 20 mg of quercetin in ethanol-water solution (the volume ratio of ethanol to water is 1:1) to obtain a quercetin solution; dissolve 80 mg of ferrous sulfate heptahydrate in 10 mL Add 240mg of polyvinylpyrrolidone with a molecular weight of 55000, sonicate for a total of 8min, then mix well by stirring for 0.5h, add the quercetin solution obtained above, and continue stirring at 500r / min for 12h to obtain a reaction solution; Add the reaction solution to a cellulose dialysis bag with a molecular weight cut-off of 100,000. After dialysis with ultrapure water for 72 hours, freeze-dry it with a freeze dryer to obtain a black powder; use ICP to quantify the iron content and store at 4°C until use .

Embodiment 2

[0064] Example 2 Synthesis of Quercetin Ruthenium Nanomedicine

[0065] Under 40KHZ 40W ultrasonic conditions, dissolve 10 mg of quercetin in methanol-water solution (the volume ratio of methanol to water is 1:1) to obtain a quercetin solution; dissolve 80 mg of ruthenium trichloride in 10 mL of ultra In pure water, add 240mg of polyarginine with a molecular weight of 55000, sonicate for a total of 9 minutes, then mix well by stirring for 0.5 hours, add the quercetin solution obtained above, and continue to stir for 36 hours at 600r / min to obtain a reaction solution; The reaction solution was added to a cellulose dialysis bag with a molecular weight cut-off of 80,000. After dialysis with ultrapure water for 70 hours, it was freeze-dried with a freeze dryer to obtain a brown-black powder; the ruthenium content was quantified by ICP and stored at 4°C for later use .

Embodiment 3

[0066] Example 3 Synthesis of Quercetin Tungsten Nanomedicine

[0067] Under 35KHZ 60W ultrasonic conditions, 30mg of quercetin was dissolved in dimethylformamide solution (the volume ratio of dimethylformamide to water was 1:1) to obtain a quercetin solution; Dissolve tungsten chloride in a 1:1 dimethylformamide aqueous solution, add 240mg of polylysine with a molecular weight of 55000, sonicate for a total of 10 minutes, then mix well by stirring for 1 hour, add the quercetin solution obtained above , Continue to stir at 800r / min for 24h to obtain the reaction solution; filter out the precipitate, add the supernatant to a cellulose dialysis bag with a molecular weight of 90,000, dialyze for 75h, dry with a freeze dryer to obtain a black powder; ICP was used to quantify the content of tungsten and stored at 4°C for later use.

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Abstract

The present invention discloses a quercetin metal nano drug and a preparation method and an application thereof. In the provided quercetin metal nano drug, quercetin and transition metal elements arecoordinated by coordination bonds, and the quercetin metal nano drug is formed by surface modification of polymers containing carbonyl groups or hydroxyl groups. The nano drug is a multifunctional nanomaterial with a tumor targeting function, can inhibit growth, invasion, metastasis, recurrence, etc. of tumor cells, even eliminates the tumor cells, and has various modes of preventing the tumors such as photothermal therapy, photodynamic therapy and radiation therapy. In addition, when the nano drug is degraded and metabolized in vivo, a produced quercetin molecule can exert the anti-tumor effect for a longer period of time, aggregation, distribution and metabolism in vivo can also be traceable, an excellent diagnosis and treatment integrated nano-platform can be formed, and the quercetin metal nano drug has a good application prospect and a broad development space in the field of medicines.

Description

Technical field [0001] The present invention belongs to the technical field of anti-tumor drugs, and more specifically, relates to a quercetin metal nano drug and a preparation method and application thereof. Background technique [0002] Traditional chemotherapy drugs have the disadvantages of poor water solubility, short blood circulation time and lack of tumor selectivity. In the organism, especially the tumor site, the pH is low and the hydrogen peroxide content is high. Because nanomaterials have good high permeability and retention effect in organisms, and excellent tumor targeting ability, people continue to explore nanomaterials, especially nanomedicine, which has become a research hotspot. [0003] Quercetin is the aglycone of naringin and belongs to the dihydroflavonoids. It has anti-inflammatory, antibacterial, anti-free radical, anti-oxidant, anti-tumor, anti-platelet coagulation and anti-atherosclerosis effects. Studies have shown that quercetin can significantly inh...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/352A61K49/10A61K49/12A61K49/14A61K49/22A61P35/00
Inventor 曹乾杨刚刚毛宗万黄华珍计亮年
Owner SUN YAT SEN UNIV
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