A kind of preparation method of gelatin-stearic acid composite gel

A composite gel and stearic acid technology, applied in the field of functional materials, to achieve the effect of uniform gel, strong practical value, and good biocompatibility

Active Publication Date: 2021-08-03
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims at the problem of the defects in the single use of gelatin and stearic acid in the prior art, and provides a preparation method of gelatin-stearic acid composite gel

Method used

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  • A kind of preparation method of gelatin-stearic acid composite gel
  • A kind of preparation method of gelatin-stearic acid composite gel
  • A kind of preparation method of gelatin-stearic acid composite gel

Examples

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Effect test

Embodiment 1

[0023] Dissolve 1g of gelatin in 9mL of water, heat at 60°C for 1h, and fully dissolve; then add 1mL of ethylene glycol to 0.02g of stearic acid, heat to dissolve, pour into the above gelatin solution, stir well to make it evenly mixed; Then add 1mL of citric acid solution with a mass fraction of 3%, continue to react for 1~4h, pour the reaction solution into a cylindrical mold, cool at room temperature to form a gel, and place it in a refrigerator (4°C) for 24h Fix the shape and freeze-dry for 48 hours to obtain a gelatin-stearic acid composite gel. The measured swelling rate is 95%, the compressive strength is 0.050MPa, and the fracture strain rate is 41.2%.

Embodiment 2

[0025] Weigh 1.5g of gelatin, dissolve in 10mL of water, heat at 60°C for 1h, and fully dissolve. Then add 1 mL of co-solvent ethylene glycol to 0.06 g of stearic acid, heat to dissolve, pour into the above gelatin solution, and mix well. Add 1mL of citric acid solution with a mass fraction of 4% to the mixture, continue to react for 1~4h, pour the reaction solution into a cylindrical mold, cool at room temperature to form a gel, and place it in a refrigerator (4°C). Place for 24 hours to fix the shape, and freeze-dry for 48 hours to obtain a gelatin-stearic acid composite gel. The measured swelling rate is 110%, the compressive strength is 0.246 MPa, and the fracture strain rate is 45.5%.

Embodiment 3

[0027] Weigh 2g of gelatin, dissolve in 10mL of water, heat at 60°C for 1h, and fully dissolve. Then add 2 mL of co-solvent ethylene glycol to 0.16 g of stearic acid, heat to dissolve, pour into the above gelatin solution, and mix well. In the mixture, add 1mL of citric acid solution with a mass fraction of 5%, continue to react for 1~4h, pour the reaction solution into a cylindrical mold, cool at room temperature to form a gel, and place it in a refrigerator (4°C) for 24h Fix the shape and freeze-dry for 48 hours to obtain a gelatin-stearic acid composite gel. The measured swelling rate is 162%, the compressive strength is 0.288MPa, and the fracture strain rate is 47.6%.

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Abstract

A preparation method of gelatin-stearic acid composite gel belongs to the technical field of functional materials, which can solve the problem of defects in the prior art when gelatin and stearic acid are used alone. A certain mass fraction of gelatin aqueous solution is heated and dissolved, and then Stearic acid with a certain mass ratio (gelatin:stearic acid) is added to the co-solvent ethylene glycol to dissolve the stearic acid, and the two are fully stirred and mixed evenly, and finally a certain amount of cross-linking agent citric acid is added to react at 60°C for a certain period of time , and then, utilize freezing-thawing method to obtain gelatin-stearic acid composite gel. The gel of the present invention can combine gelatin and stearic acid organically, and the prepared gel is uniform, and its mechanical strength is increased compared with that of pure gelatin gel; the raw materials used are all intermediate products of biological metabolism, have good biocompatibility, and are nontoxic; The process is simple and the conditions are mild, and it can be used as a slow-release drug carrier, tissue engineering material, etc., expanding the application range of gelatin.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a method for preparing a gelatin-stearic acid composite gel. Background technique [0002] Gelatin is a partial hydrolyzate of collagen, a natural amphoteric biopolymer, which is widely used in food, medicine and other fields due to its characteristics of regeneration, low cost, biocompatibility and biodegradability. In addition to the characteristics of water holding capacity, film forming property, emulsifying property and foaming property, gelatin also has unique gel properties, and is the best raw material for preparing gels. In fact, there are a large number of hydroxyl groups, carboxyl groups and amino groups in the molecular structure of gelatin , which is conducive to the modification of chemical cross-linking to prepare composite gels. The cross-linking agents used in the current published patents include chitosan, polyglycol, starch, etc. Howeve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L89/00C08K5/09
Inventor 靳利娥庞国忠史泽毅杨冬花曹青
Owner TAIYUAN UNIV OF TECH
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