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Epigallocatechin gallate microcapsule powder and preparation method thereof

A technology of epigallocatechin and gallate, applied in the field of epigallocatechin gallate microcapsule powder and preparation thereof, can solve the problems of affecting EGCG activity, reducing bioavailability, pain and the like

Inactive Publication Date: 2019-06-11
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw material of EGCG has an inherent bitter taste, which brings great pain to the people who take it
And most of the products on the market are mixed with a large amount of flavor additives to cover up its taste
Some additives can also affect the activity of EGCG, resulting in a decrease in its bioavailability

Method used

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  • Epigallocatechin gallate microcapsule powder and preparation method thereof
  • Epigallocatechin gallate microcapsule powder and preparation method thereof
  • Epigallocatechin gallate microcapsule powder and preparation method thereof

Examples

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Effect test

preparation example Construction

[0029] More specifically, the above-mentioned EGCG microcapsule powder preparation method comprises the following steps:

[0030] ① Prepare the raw materials epigallocatechin gallate, hydroxypropyl methylcellulose, ascorbic acid, microcrystalline cellulose and hydrogenated palm oil so that the mass ratio is 10~40:8:10~40:20~80: 15;

[0031] ② Mix and stir hydroxypropyl methylcellulose and water according to the mass ratio of 1:50 until completely dissolved to obtain slurry I;

[0032] ③Mix epigallocatechin gallate (EGCG), microcrystalline cellulose, ascorbic acid and slurry I, and granulate in a high-shear granulator at a stirring speed of 2000rpm, a cutter speed of 2500rpm, granulate for 2min, flow After melting and drying, it is made into Granule II;

[0033] ④ Use hydrogenated palm oil as the embedding agent to coat the granule II, the material temperature is 45°C, and the air volume is 35m 3 / h, embedding for about 30min to prepare epigallocatechin gallate microcapsule ...

Embodiment 1

[0040] Embodiment 1: EGCG microcapsule powder A and evaluation thereof

[0041] (1) 660g of microcrystalline cellulose and 16g of hydroxypropyl methylcellulose (viscosity 15mpa.s) were dropped into 800ml water to be prepared into a uniform emulsion; 170g of EGCG raw material powder and 170g of ascorbic acid raw material were weighed and mixed and stirred evenly to prepare mixture Ia;

[0042] (2) Pour the mixture Ia into a high-shear granulator for granulation, with a stirring speed of 2000rpm, a cutter speed of 2500rpm, and 2min. Use a 30-mesh sieve to make granules and place them in a fluidized bed at an inlet temperature of 55 ℃, air volume 35m 3 / h heating for about 1h to obtain EGCG semi-finished particles Sa.

[0043] (3) EGCG semi-finished granules Sa are placed in a fluidized bed, the material temperature is 45°C, and the air volume is 35m 3 / h, using hydrogenated palm oil to embed for about 30min to obtain EGCG microcapsule powder A.

[0044] The EGCG microcapsule ...

Embodiment 2

[0046] Embodiment 2: EGCG microcapsule powder B and its evaluation

[0047] (1) 745g of microcrystalline cellulose and 16g of hydroxypropyl methylcellulose (viscosity 15mpa.s) are dropped into 800ml water to be mixed with a uniform emulsion, and 170g of EGCG raw material powder and 85g of ascorbic acid raw material are mixed and stirred evenly, and prepared as mixture 1b ;

[0048] (2) The mixture Ib is poured into a high-shear granulator for granulation, the stirring speed is 2000rpm, the cutter speed is 2500rpm, 2min, and the EGCG particles are made by 30 mesh sieve granulation and placed in a fluidized bed with an inlet air temperature of 55 ℃, air volume 35m3 / h heat drying for about 1h to obtain EGCG semi-finished particles Sb.

[0049] (3) EGCG semi-finished granules Sb are placed in a fluidized bed with a material temperature of 45°C and an air volume of 35m3 / h, and are embedded in hydrogenated palm oil for about 30 minutes to obtain EGCG microcapsule powder B;

[0050...

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Abstract

The invention provides epigallocatechin gallate microcapsule powder and a preparation method thereof. The preparation method comprises the following steps: (1) mixing by stirring an adhesive and wateruntil the adhesive completely dissolves to prepare slurry I; (2) mixing epigallocatechin gallate, an excipient, an antioxidant and the slurry I, and carrying out granulating into particles II in a high-shear granulator; and (3) coating the particles II with an embedding agent. According to the method, the EGCG is treated through granulation, embedding and other processes, and the product has particularly excellent moisture absorption resistance, oxidation resistance and taste masking characteristics. The prepared EGCG microcapsule powder has drug loading capacity between 10% and 40%, spherical or sphere-like appearance, a particle size of 0.3-0.8 mm, and excellent product fluidity. The epigallocatechin gallate microcapsule powder is suitable for being taken or applied in various forms such as capsules, tablets or disposable preparations.

Description

technical field [0001] The invention relates to epigallocatechin gallate microcapsule powder and a preparation method thereof, belonging to the field of health food and pharmaceutical preparations. Background technique [0002] Tea contains a large amount of polyphenolic compounds, which are collectively called tea polyphenols (TP), accounting for about 18-36% of the dry weight of tea. Tea polyphenols include flavanols (also known as catechins), flavonoids (anthocyanins), flavonols (flavonols and their glycosides), hydroxyl-4-flavanols and their salts ( anthocyanins, anthocyanins), phenolic and depsipated acids, and other polyphenols. Catechin compounds are the main components of tea polyphenols, accounting for about 70% to 80% of the total amount of tea polyphenols, mainly containing: epigallocatechin gallate (EGCG), epicatechin gallate ( ECG), epigallocatechin (EGC), epicatechin (EC), gallocatechin gallate (GCG), catechin (C), gallocatechin (GC), etc., among which EGCG ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/44A61K47/12A61K47/14A61K31/353A61P39/06A61P29/00A61P35/00A61P9/10A61P7/02
Inventor 陈剑彬吕福臻张正雨吴文忠
Owner INNOBIO CORP LTD
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