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Auricularia auricula hypolipidemic active part and preparation method and application thereof

The technology of active parts and black fungus is applied in the field of preparation of blood lipid-lowering active parts in black fungus, can solve the problems of obvious toxic and side reactions, easy rebound and high price, and achieves the effects of clear chemical composition, improved effect and increased content.

Active Publication Date: 2019-06-14
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the above chemical drugs have the disadvantages of high price, obvious toxic and side effects, and easy rebound after drug withdrawal; therefore, seeking new drug sources has become one of the research hotspots in the medical field

Method used

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  • Auricularia auricula hypolipidemic active part and preparation method and application thereof
  • Auricularia auricula hypolipidemic active part and preparation method and application thereof
  • Auricularia auricula hypolipidemic active part and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A black fungus hypolipidemic active part, by weight, the total triterpene content of the active part is 15.6-35.9%, the total polyphenol content is 28.4-53.6%, and the weight ratio of triterpenoids to polyphenols is 1: (1.5-2.9).

[0034] An application of the active site in the preparation of blood lipid-lowering drugs.

[0035] A method for preparing the blood lipid-lowering active part of black fungus, comprising the following steps:

[0036] (1) Enzymolysis: Take 50g of black fungus, dry it at 50 degrees, and crush it. 100U compound enzyme solution of dry fungus powder, enzymatic hydrolysis at 40 degrees for 4 hours, heat inactivation of compound enzyme after enzymolysis;

[0037] (2) Extraction: add the above-mentioned enzymatic hydrolysis product into the extraction solution to be 60% ethanol aqueous solution, the dosage is 3 times the weight-volume ratio of the crude drug, the heating and reflux time is 4 hours, the extraction solution is refluxed and extracted...

Embodiment 2

[0042] A black fungus hypolipidemic active part, by weight, the total triterpene content of the active part is 15.6-35.9%, the total polyphenol content is 28.4-53.6%, and the weight ratio of triterpenoids to polyphenols is 1: (1.5-2.9).

[0043] An application of the active site in the preparation of blood lipid-lowering drugs.

[0044]A method for preparing the blood lipid-lowering active part of black fungus, comprising the following steps:

[0045] (1) Enzymolysis: Take 50g of black fungus, dry it at 50 degrees, and crush it. 100U compound enzyme solution of dry fungus powder, enzymatic hydrolysis at 40 degrees for 4 hours, heat inactivation of compound enzyme after enzymolysis;

[0046] (2) Extraction: the product after the above enzymolysis is extracted by adding 70% ethanol aqueous solution for ultrasonic extraction, the amount of 70% ethanol aqueous solution is 3 times the weight-volume ratio of the crude drug, the ultrasonic frequency is 300KHz, the ultrasonic temper...

Embodiment 3

[0052] A black fungus hypolipidemic active part, by weight, the total triterpene content of the active part is 16.7-21.1%, the total polyphenol content is 46.4-53.6%, and the weight ratio of triterpenoids and polyphenols is 1: (2.2-2.9).

[0053] An application of the active site in the preparation of blood lipid-lowering drugs.

[0054] A method for preparing the blood lipid-lowering active part of black fungus, comprising the following steps:

[0055] (1) Enzymolysis: Take 50g of black fungus, dry it at 50 degrees, and crush it. 100U compound enzyme solution of dry fungus powder, enzymatic hydrolysis at 40 degrees for 4 hours, heat inactivation of compound enzyme after enzymolysis;

[0056] (2) Extraction: add the above-mentioned enzymolysis product into the extraction solution to be 70% ethanol aqueous solution, the dosage is 5 times the weight-volume ratio of the crude drug, the heating and reflux time is 4 hours, the extraction solution is refluxed and extracted 3 times...

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Abstract

The invention relates to an auricularia auricula hypolipidemic active part and a preparation method and application thereof. The active part, with an in-vitro inhibition effect on lipase, of auricularia auricula is obtained through a preparation method. Animal experiments show that the active part has a hypolipidemic effect; it is tested that the active part comprises 15.6-35.9% of triterpenoid components and 28.4-53.6% of polyphenol components, and the activity is high when the mass ratio of the triterpenoid components to the polyphenol components is 1:(2.2-2.9). The active part of the auricularia auricular can be used for preparing hypolipidemic drugs, and has good development and application prospects. The invention further discloses a main ingredient range of the auricularia auricula hypolipidemic active part. Quality standard improvement and control are facilitated during later development and application.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract with blood lipid-lowering activity, in particular to a preparation method and application of the blood-lipid-lowering active part in black fungus. Background technique [0002] Hyperlipidemia refers to blood cholesterol and / or triglycerides too high or high-density lipoprotein cholesterol too low, modern medicine is often referred to as dyslipidemia, also often referred to as hyperlipoproteinemia. Hyperlipidemia and lipid metabolism disorders are the main risk factors for atherosclerosis. The resulting cardiovascular and cerebrovascular diseases seriously endanger human health, and sometimes can lead to hypertension, diabetes, coronary heart disease and other diseases, causing renal failure, etc. . With the continuous improvement of living standards and changes in dietary structure, hyperlipidemia has shown a high incidence trend, and chronic medical diseases such as arteriosclerosis, cor...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P3/06
Inventor 郭玉岩孙爽吕邵娃李永吉杨大宇
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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