Method for preparing royal jelly acid

A technology of royal jelly acid and methyl propiolate, applied in carboxylate preparation, organic chemistry, etc., can solve the problems of high requirements for reaction conditions, high production costs, hindering the progress of the reaction, etc., and achieves easy industrial production and short reaction route , the effect of high total yield
CN109942397AActive Publication Date: 2019-06-28JIAXING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIAXING UNIV
Publication Date
2019-06-28

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Abstract

The invention discloses a method for preparing royal jelly acid, and belongs to the field of chemical synthesis. The method comprises the steps that methyl propiolate and 7-bromine heptanol are adopted as initial raw materials, and in a solvent, 10-hydroxyl-2-methyl decylenate is obtained under the action of strong base sodamide; in a liquid ammonia solvent, metal sodium is utilized for carrying out trans-reduction, and (E)-10-hydroxyl-2-methyl decylenate is obtained; hydrolysis is carried out under the action of alkali, then acidizing is carried out, and the target product jelly acid is obtained. According to the method for preparing the jelly acid, the technical route has the advantages of being short, easy and convenient to operate and easy for industrial production, and the method forsynthesizing the royal jelly acid is economical, simple and convenient.
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Description

technical field

[0001] The invention belongs to the field of chemical synthesis, and more specifically relates to a preparation method of royal jelly acid. Background technique

[0002] Royal jelly acid is the main organic component of royal jelly, and its content is one of the main indicators to measure the quality of royal jelly. Its chemical name is (E)-10-hydroxy-2-decenoic acid, or 10-HDA for short. Because of its anti-bacterial, anti-cancer, anti-radiation and strong body and other physiological functions, it has attracted the attention of workers in the fields of chemistry, biology and medicine. At present, royal jelly and its products have become best-selling products in domestic and foreign markets. Although royal jelly acid can be extracted from royal jelly, the product prepared by synthetic method has high purity and quality is easier to guarantee. There are many synthetic routes published at home and abroad, but from a practical point of view, many routes are ei...

Claims

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