Fructus jujubae and radix astragali mixed fermented traditional Chinese medicine immunomodulator and preparation method thereof

An immunomodulator, mixed fermentation technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as products that have not been reported in literature, and achieve enhancement of cellular immunity and humoral immunity. Globulin and antibody levels, and the effect of improving immunity

Inactive Publication Date: 2019-07-05
ZHENGZHOU NUBLION BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, fermented products such as jujube and astragalus are widely used in various countries and regions by using only one kind of probiotics alone, but Lactobacillus plantarum, Lactobacillus acidophilus, Clostridium butyricum, yeast, Bacillus subtilis and Lactococcus and other probiotics are combined to ferment traditional Chinese medicines such as jujube and astragalus, and finally make an immunomodulator that integrates "traditional Chinese medicine and probiotics", so that products that can exert the synergistic effect of probiotics and traditional Chinese medicine have not yet been reported in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A traditional Chinese medicine immunomodulator mixed with jujube and astragalus, which is made by adding 3% probiotic fermentation broth to fermented raw materials for solid fermentation, and each 100 g of fermented raw materials contains 40 g of jujube, 15 g of astragalus, 20 g of alfalfa, and 5 g of soybean meal , corn 10g, meat powder 5g, insect protein 5g.

[0040] The probiotic fermentation liquid is cultured probiotic culture liquid, and the probiotics include Lactobacillus plantarum and Lactobacillus acidophilus.

[0041] Its preparation method comprises the following steps:

[0042] (1) Crushing and feeding: Crush red dates, astragalus, alfalfa, corn, soybean meal and other raw materials, pass through 40 meshes, accurately weigh the required raw materials according to the ratio, put them into the material tank, dry mix for 20 minutes, and stir evenly.

[0043] (2) Bacteria-added liquid: Add 3% probiotic fermentation liquid by weight of raw materials into the ab...

Embodiment 2

[0049] A traditional Chinese medicine immunomodulator mixed with jujube and astragalus, which is made by adding 5% probiotic fermentation liquid to the fermentation raw material for solid fermentation. Every 100 g of fermented raw material contains 55 g of jujube, 15 g of astragalus, 20 g of alfalfa, soybean meal 2g, corn 4g, meat powder 2g, insect protein 2g.

[0050] The probiotic fermentation liquid is cultured probiotic culture liquid, and the probiotics include Clostridium butyricum, saccharomyces, and Lactococcus.

[0051] Its preparation method comprises the following steps:

[0052] (1) Grinding and feeding: Grind red dates, astragalus, alfalfa, corn, soybean meal and other raw materials through 80 meshes, accurately weigh the required raw materials according to the ratio regulations, put them into the material tank, dry mix for 10 minutes, and stir evenly.

[0053] (2) Bacteria-added liquid: Add 5% probiotic fermentation liquid by weight of raw materials into the abo...

Embodiment 3

[0059] A traditional Chinese medicine immunomodulator mixed with jujube and astragalus, which is made by adding 4% probiotic fermentation liquid to the fermentation raw materials for solid fermentation. Every 100 g of fermentation raw materials contains 55 g of red dates, 12 g of astragalus, 18 g of alfalfa, and soybean meal 3g, corn 6g, meat meal 3g, insect protein 3g.

[0060] The probiotic fermentation liquid is cultured probiotic culture liquid, and the probiotics include Lactobacillus acidophilus, Clostridium butyricum, saccharomyces, and Lactococcus.

[0061] Its preparation method comprises the following steps:

[0062] (1) Crushing and feeding: Crush red dates, astragalus, alfalfa, corn, soybean meal and other raw materials, pass through 60 meshes, accurately weigh the required raw materials according to the ratio, put them into the material tank, dry mix for 10 minutes, and stir evenly.

[0063] (2) Bacteria-added liquid: Add probiotic fermentation liquid with 4% wei...

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PUM

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Abstract

The invention provides a fructus jujubae and radix astragali mixed fermented traditional Chinese medicine immunomodulator and a preparation method thereof. The immunomodulator is an additive made by adding 3-5% of probiotic fermentation liquor into a fermentation raw material through solid fermentation. The fermentation material, per 100g, comprises 40-55g of red dates, 10-15g of radix astragali,15-20g of alfalfa, 2-5g of bean pulp, 4-10g of corns, 2-5g of meat powder and 2-5g of insect protein. The probiotic fermentation liquor contains more than two probiotics including lactobacillus plantarum, lactobacillus acidophilus, clostridium butyricum, saccharomycetes, bacillus subtilis or lactobacillus. The immunomodulator has a unique fermentation aroma and is rich in nutrition and capable ofgiving play to synergistic effects of probiotics and traditional Chinese medicines, maintaining gastrointestinal micro-ecological flora balance and improving immunity of animals, the immunomodulator can also be used for improving appetite of mammals and increasing food intake of the mammals to increase milk nutrient content, body immunity of female animals is enhanced, the disease rate is decreased, and growth and development of bred animals are promoted.

Description

technical field [0001] The patent of the invention belongs to the category of additives, and specifically relates to a traditional Chinese medicine immunomodulator mixed with fermented jujube and astragalus and a preparation method thereof. Background technique [0002] Traditional Chinese medicine immunomodulators refer to Chinese patent medicines (including some extracts) that have the function of enhancing and regulating immunity in anti-infection, anti-virus, anti-tumor, anti-allergic, asthma, etc., and are mainly used clinically for infectious diseases, Adjuvant therapy for certain autoimmune diseases and tumors. With the abuse of antibiotics and the increasingly serious problem of drug residues in animal products, food safety issues are increasingly concerned by people. Traditional Chinese medicine has become the focus of everyone's research because of its advantages of "safety, greenness, and no residue". Traditional Chinese medicine and probiotics have become substi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K38/02A61P37/04A61P1/14A61P1/00A61K35/747A61K35/742A61K36/064A61K35/744A61K35/741
CPCA61K35/741A61K35/742A61K35/744A61K35/747A61K36/064A61K36/48A61K36/481A61K36/725A61K36/899A61K38/02A61K2236/19A61P1/00A61P1/14A61P37/04A61K2300/00
Inventor 常功王福芳孟春萍
Owner ZHENGZHOU NUBLION BIOTECH
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