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Preparation method of flavonoid magnetic molecularly imprinted polymer

A magnetic molecular imprinting and polymer technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of large consumption of organic solvents, low sensitivity, long analysis process, etc., and achieve fast binding kinetics and high specificity. Ability to identify, prepare simple effects

Active Publication Date: 2021-06-18
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, traditional sample pretreatment methods such as Soxhlet extraction, liquid-liquid extraction, liquid phase microextraction, and solid phase microextraction are cumbersome to operate, consume a lot of organic solvents, and have poor selectivity, often resulting in long analysis procedures and low sensitivity.

Method used

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  • Preparation method of flavonoid magnetic molecularly imprinted polymer
  • Preparation method of flavonoid magnetic molecularly imprinted polymer
  • Preparation method of flavonoid magnetic molecularly imprinted polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: The preparation method of this flavonoid magnetic molecularly imprinted polymer is as follows:

[0029] (1) FeCl 2 4H 2 O and FeCl 3 ·6H 2 O was dissolved in deionized water and stirred at 75°C under nitrogen protection for 60 minutes; then 1 mL of oleic acid was added dropwise to each 100 mL of the mixed solution for 30 minutes, and then 10 mL of ammonium hydroxide was added dropwise to each 100 mL of the mixed solution for 30 minutes. After completion, the product was naturally cooled to room temperature, separated under the action of an external magnetic field, and the solid was washed with ethanol and deionized water for 3 times, and dried in vacuum at 40°C to obtain Fe 3 o 4 Magnetic nanoparticles, where FeCl 2 4H 2 O and FeCl 3 ·6H 2 The mass ratio of O is 1:2.5, Fe 2+ The concentration in deionized water is 4mmol / L;

[0030] (2) Incorporate step (1) Fe 3 o 4 Ultrasonic dispersion of magnetic nanoparticles in 80% ethanol solution, Fe3 o 4 T...

Embodiment 2

[0041] Example 2: The preparation method of this flavonoid magnetic molecularly imprinted polymer is as follows:

[0042] (1) FeCl 2 4H 2 O and FeCl 3 ·6H 2 O was dissolved in deionized water, and stirred at 80°C for 45 minutes under nitrogen protection; then 3 mL of oleic acid was added dropwise to each 100 mL of the mixed solution for 40 minutes, and then 15 mL of ammonium hydroxide was added dropwise to each 100 mL of the mixed solution for 40 minutes. After completion, the product was naturally cooled to room temperature, separated under the action of an external magnetic field, the solid was washed with ethanol and deionized water for 4 times, and dried in vacuum at 60°C to obtain Fe 3 o 4 Magnetic nanoparticles, where FeCl 2 4H 2 O and FeCl 3 ·6H 2 The mass ratio of O is 1:3, Fe 2+ The concentration in deionized water is 5mmol / L;

[0043] (2) Incorporate step (1) Fe 3 o 4 Ultrasonic dispersion of magnetic nanoparticles in 85% ethanol solution, Fe 3 o 4 The ...

Embodiment 3

[0046] Example 3: The preparation method of this flavonoid magnetic molecularly imprinted polymer is as follows:

[0047] (1) FeCl 2 4H 2 O and FeCl 3 ·6H 2 O was dissolved in deionized water and stirred at 85°C under nitrogen protection for 30 minutes; then 5 mL of oleic acid was added dropwise to each 100 mL of the mixed solution for 55 minutes, and then 12 mL of ammonium hydroxide was added dropwise to each 100 mL of the mixed solution for 50 minutes. After completion, the product was naturally cooled to room temperature and separated under the action of an external magnetic field. The solid was washed three times with ethanol and deionized water in turn, and dried in vacuum at 50°C to obtain Fe 3 o 4 Magnetic nanoparticles, where FeCl 2 4H 2 O and FeCl 3 ·6H 2 The mass ratio of O is 1:4, Fe 2+ The concentration in deionized water is 6mmol / L;

[0048] (2) Incorporate step (1) Fe 3 o 4 Ultrasonic dispersion of magnetic nanoparticles in 90% ethanol solution, Fe 3...

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Abstract

The invention discloses a preparation method of a flavonoid magnetic molecularly imprinted polymer, which belongs to the technical field of drug analysis; the method of the invention adopts a surface molecular imprinting technology to prepare a magnetic molecularly imprinted nanomaterial capable of adsorbing quercetin; the prepared magnetic molecularly imprinted nanomaterial The polymer is in a regular spherical shape, and contains holes of specific shape and size left by multiple template molecules on the surface of the polymer, and there are binding sites in a specific arrangement in the holes; the performance of the magnetic molecularly imprinted nanomaterial prepared by the present invention is significantly better than that of the traditional The enrichment material is simple to prepare, cheap and easy to obtain, and has excellent selectivity and adsorption capacity for template molecules.

Description

technical field [0001] The invention belongs to the technical field of drug separation, in particular to a method for preparing a flavonoid magnetic molecularly imprinted polymer, and using the magnetic molecularly imprinted polymer as an adsorbent to selectively separate and enrich quercetin in natural products and its structure analog. Background technique [0002] Quercetin (Quercetin) is a polyhydroxy flavonoid compound, which widely exists in the flowers, leaves and fruits of Chinese herbal medicines. The efficacy of blood vessels, so it can be used in functional food and pharmaceutical industries; however, the quercetin sample matrix that exists under natural conditions is relatively complex, the content is low, and it has a similar structure to other flavonoids. Therefore, exploring a new method for rapid extraction, separation and enrichment of quercetin is an urgent task for analytical researchers. [0003] Since Wulff's research group reported artificially synthe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/56C08F220/06C08K9/06C08K3/22C08K3/36C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08F222/10C08J9/26C08J2335/02C08K3/22C08K3/36C08K9/06C08K2003/2275C08F222/102C08F220/56C08F220/06
Inventor 胡旭佳谢增辉
Owner KUNMING UNIV OF SCI & TECH
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