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Compound apium graveolens seed oil fatty milk preparation with anti-aging effects and preparation method thereof

A technology of celery seed oil and emulsion preparation, which is applied in the field of medicine, can solve the problems of low bioavailability, achieve the effects of improving bioavailability, enhancing anti-aging effect, and improving bioavailability

Pending Publication Date: 2019-07-19
江苏圣典医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to certain fatty acids, celery seed oil also contains a relatively large amount of volatile terpenoids. In the process of preparation, it is necessary to pay attention to the volatility of celery seed oil. Therefore, the common preparation of celery seed oil and its fat emulsion preparation In comparison, not only its bioavailability is relatively low, but also the volatility of celery seed oil is difficult to solve

Method used

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  • Compound apium graveolens seed oil fatty milk preparation with anti-aging effects and preparation method thereof
  • Compound apium graveolens seed oil fatty milk preparation with anti-aging effects and preparation method thereof
  • Compound apium graveolens seed oil fatty milk preparation with anti-aging effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: Compound Celery Seed Oil Fat Emulsion Injection Preparation One

[0050] 1. The ingredients are as shown in Table 1:

[0051] Table 1 Composition of Compound Celery Seed Oil Fat Emulsion Injection 1

[0052]

[0053] 2. Preparation method

[0054] (1) In a water bath at about 56°C and under the protection of nitrogen, take 60g of perilla seed oil for injection, add 30g of peony seed oil and mix evenly, then add 10g of celery seed oil and stir until uniform, add 20g of soybean lecithin and 100mg of vitamin E Stir until the phospholipid dissolves to form a uniform mixed phase, then cool to room temperature to obtain an oil phase;

[0055] (2) Under the protection of a water bath at about 56°C and nitrogen, put 800ml of water for injection into a container, add 40g of povidone, 22g of glycerin and 15g of egg yolk lecithin for shearing and stirring to dissolve and mix evenly, and cool to room temperature to obtain an aqueous phase;

[0056] (3) Under st...

Embodiment 2

[0060] Embodiment 2: preparation two of compound celery seed oil fat emulsion injection

[0061] 1. The ingredients are as shown in Table 2:

[0062] Table 2 Composition of Compound Celery Seed Oil Fat Emulsion Injection II

[0063]

[0064]

[0065] 2. Preparation method

[0066] (1) In a water bath at about 58°C and under nitrogen protection, take 60g of perilla seed oil for injection, add 25g of eucommia seed oil for injection and mix evenly, then add 15g of celery seed oil and stir until uniform, add 15g of egg yolk lecithin, vitamin C 100mg was stirred until the phospholipids were dissolved to form a uniform mixed phase, cooled to room temperature to obtain an oil phase;

[0067] (2) Under the protection of a water bath at about 58°C and nitrogen, put 800ml of water for injection into a container, add 30g of polyethylene glycol, 22g of glycerin, and 15g of egg yolk lecithin for shearing and stirring to dissolve and mix evenly, and cool to At room temperature, the...

Embodiment 3

[0072] Embodiment 3: preparation three of compound celery seed oil fat emulsion injection

[0073] 1. The ingredients are as shown in Table 3:

[0074] Table 3 Composition 3 of Compound Celery Seed Oil Fat Emulsion Injection

[0075]

[0076]

[0077] 2. Preparation method

[0078] (1) Under the protection of water bath and nitrogen at about 59°C, take 35g of peony seed oil for injection, add 25g of eucommia seed oil for injection, 20g of perilla seed oil and mix well, then add 20g of celery seed oil and stir until uniform, add egg yolk Stir 15g of lecithin and 100mg of vitamin E until the phospholipids are dissolved to form a uniform mixed phase, and cool to room temperature to obtain an oil phase;

[0079] (2) Under the protection of a water bath at about 59°C and nitrogen, put 800ml of water for injection into a container, add 25g of povidone, 22g of glycerin, and 20g of egg yolk lecithin for shearing and stirring to dissolve and mix evenly, and cool to room tempera...

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Abstract

The invention discloses a compound apium graveolens seed oil fatty milk preparation with anti-aging effects and a preparation method thereof. The preparation comprises apium graveolens seed oil, compounded with a vegetable fat oil formula with anti-aging effects and capable of significantly enhancing the anti-aging effects of apium graveolens seed oil, performs dissolution, dispersion and protection on the apium graveolens seed oil, compounded with phospholipids and / or monofatty acid glycerides as an emulsifier, compounded with oleic acid, linoleic acid, cholic acid or difatty acid glyceridesas a co-emulsifier, and added an additive and water. The emulsion is prepared. By using fatty milk as a drug delivery carrier for an apium graveolens seed oil extract, meanwhile, the compounded vegetable fat oil formula and the emulsifier are functional components, the prepared compound apium graveolens seed oil fatty milk preparation is non-toxic, and has a uniform particle size, high bioavailability and good stability. Furthermore, the preparation can administrate a drug in various ways, allows to fully developing medicinal and health care functions of apium graveolens seed oil and other compounds, and can improve health condition of the human body and the ability of disease resistance.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a celery seed oil and a compound celery seed oil fat emulsion with anti-aging effects and a preparation method thereof. Background technique [0002] Celery seed oil is a hydrophobic yellow-green translucent oil extracted from celery seeds. Celery seed is the seed of celery (Apium graveolens L.). Celery is an annual or biennial herb plant, which is cultivated all over the world. Celery not only has high edible value, but the oil extracted from its fruit is a yellow-green translucent oily liquid with a unique fresh aroma. It can be used as a seasoning spice in seasoning Widely used in pharmaceuticals, medicine, cosmetics and other fields. Celery seed oil is different from general vegetable seed oil. In addition to the fatty acid components contained in general vegetable seed oil, celery seed oil also contains a large amount of volatile oil (that is, celery seed esse...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61K36/71A61K36/65A61K36/535A61K36/46A61K36/55A61K36/47A61K9/107A61K47/44A61K47/24A61P39/06A23L33/105
CPCA23V2002/00A61K9/0019A61K9/0053A61K9/107A61K36/23A61K36/46A61K36/47A61K36/535A61K36/55A61K36/65A61K36/71A61K47/24A61K47/44A23L33/105A61P39/06A61K2300/00A23V2200/302
Inventor 陈苏云
Owner 江苏圣典医药科技有限公司
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