Liranaftate topical solution for treating fungal infection in pets and preparation method thereof

A technology for liranaftate and fungal infection, which is applied in the direction of medical preparations, antifungal agents, and pharmaceutical formulations of non-active ingredients, and can solve problems such as strong skin irritation, inconvenience to users, and obstacles, and achieve simple procedures, Ease of large-scale preparation, the effect of treating fungal infections in pets

Active Publication Date: 2021-08-06
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zefnart Solution 2% mainly exerts its antifungal effect through drug penetration into the sebum, but this product has certain skin irritation, especially when the affected area is damaged due to scratching, the skin irritation is more intense, which brings inconvenience to the user. It also has greater obstacles when it is promoted as pet medicine

Method used

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  • Liranaftate topical solution for treating fungal infection in pets and preparation method thereof
  • Liranaftate topical solution for treating fungal infection in pets and preparation method thereof
  • Liranaftate topical solution for treating fungal infection in pets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 2

[0030] Preparation Example 2: Preparation of liranaphtate solution of the present invention

[0031] The components are as follows:

[0032]

[0033] Preparation method: In step A, at room temperature of 25°C, put the weighed liranaftyl ester, BHT, and BHA into the weighed ethyl acetate, diethyl sebacate, and appropriate amount of glycerin fatty acid ester, palm Stir in a stirring tank of isopropyl phosphate, the stirring speed range is 1000rpm / min, and the stirring time range is 30min, until it is completely dissolved, then add the remaining glycerin fatty acid ester to constant volume, and filter with a 0.45um nylon filter membrane to obtain a semi-finished product.

[0034] In step B, the above-mentioned semi-finished product is taken, filled and packaged.

Embodiment 3

[0035] The skin irritation research of embodiment 3 non-broken skin:

[0036] 3.1 Test items

[0037] Test drug:

[0038] Prepared by Luoyang Huizhong Veterinary Medicine Co., Ltd.; liranaphtate topical solution prepared in Example 1 of the present invention; liranaphtate topical solution prepared in Example 2 of the present invention; Japanese product ZEFNARTSOLUTION 2%.

[0039] Test animals:

[0040] 10 New Zealand white rabbits, weighing 2.5-3kg, half male and half male.

[0041] 3.2 Operation steps

[0042] Preparation of Rabbit Skin

[0043] Shave the hair on both sides of the rabbit’s back and spine 24 hours before administration. The shaved area on each side is about 3cm×3cm. Before administration, check whether the depilated skin is damaged due to depilation. Eight fur rabbits were used for the experiment.

[0044] Method of administration

[0045] Select 8 rabbits with intact skin after shaving, apply 0.5mL / only on the skin that has been shaved on the left sid...

Embodiment 4

[0067] Embodiment 4 damaged skin irritation research:

[0068] 4.1 Test items

[0069] Test drug:

[0070] Luoyang Huizhong Veterinary Medicine Co., Ltd.; liranaphtate topical solution prepared in Example 1 of the present invention; liranaphtate topical solution prepared in Example 2 of the present invention; Japanese product ZEFNARTSOLUTION 2%.

[0071] Test animals:

[0072] 10 New Zealand white rabbits, weighing 2.5-3kg, half male and half male.

[0073] 4.2 Test steps

[0074] Preparation of Rabbit Skin

[0075] 24 hours before the administration, the hair on both sides of the rabbit's back spine was shaved, and the shaved area on each side was about 3cm×3cm. Eight hairless rabbits were tested.

[0076] Method of administration

[0077] Select 8 rabbits with damaged skin after shaving, apply 0.5mL / only on the skin that has been shaved on the left side, and then cover with two layers of gauze (2.5cm×2.5cm) and a non-irritating plastic film , then fixed with non-irri...

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PUM

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Abstract

The invention relates to a solution containing liranaphtate for treating fungal infections in pets. The liranatate solution contains: a solvent glycerin fatty acid ester, a cosolvent ethyl acetate, a bacteriostatic agent monoglyceride laurate, and liranatate naphthyl esters. The liranaftate solution of the invention can be directly applied to damaged skin, and the acceptability is increased when applied to pets, and the drug effect is equivalent to that of commercial products.

Description

technical field [0001] The invention relates to the invention of pet skin disease medicines, in particular to a solution for treating fungal infection of pets. Background technique [0002] Pet fungal infection is one of the common pet skin diseases in my country, accounting for 41.75% of pet skin diseases. It not only seriously affects the health of pets, but also creates favorable conditions for other pathogens to invade the skin. In particular, pets have a high probability of being infected with Microsporum canis. After infection, skin lesions and itching symptoms will occur, causing animals to scratch continuously, which will cause damage to animal skin hair follicles, rough animal fur, and affect the appearance of animals. Cause secondary infection with other fungi and bacteria. [0003] Liranaftate is a new type of third-generation thiocarbamic acid antifungal drug, which is a new product of the third class of chemical drugs. It is a squalene cyclooxygenase inhibitor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/44A61P31/10
CPCA61K9/0017A61K9/08A61K31/44A61K47/14
Inventor 张许科田朋飞
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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