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Preparation method and application of near-infrared responsive carbon dots

A near-infrared and carbon dot technology, applied in chemical instruments and methods, medical preparations containing active ingredients, nano-carbon, etc., can solve the problems of low output, high cost, and restrictions on the application of carbon quantum dots, and achieve low therapeutic power Effect

Active Publication Date: 2022-07-26
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, using traditional methods to prepare carbon quantum dots, the disadvantages of long preparation period, high cost and low yield limit the application of carbon quantum dots in the field of photothermal therapy.

Method used

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  • Preparation method and application of near-infrared responsive carbon dots
  • Preparation method and application of near-infrared responsive carbon dots
  • Preparation method and application of near-infrared responsive carbon dots

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Experimental program
Comparison scheme
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Embodiment 1

[0052] The present embodiment is a preparation method of near-red second region responsive carbon dots, which comprises the following steps:

[0053] 1) Add 2g of pyrene to 160mL of concentrated nitric acid, condense and reflux at 80°C for 24h, wash the acid in the solution by diluting the obtained mixture continuously with deionized water, and finally remove large particles with a 220nm filter membrane, and then dry to obtain trinitrate Pyrene powder.

[0054] 2) Take 0.1 g of trinitropyrene obtained in the first step, dissolve 0.1 g of polyethyleneimine in 10 mL of deionized water, stir and mix with trinitropyrene, put it into a microwave reactor, and react at 150°C for 120 min.

[0055] 3) The black liquid obtained in step 2 is passed through a 220nm filter membrane, and the filtrate is transferred to the dichloromethane phase, and is filtered with a neutral alumina chromatographic column to remove the small molecular organic matter that is the reaction, and then oven dry t...

Embodiment 2

[0057] The present embodiment is a preparation method of near-red second region responsive carbon dots, which comprises the following steps:

[0058] 1) Add 3g of pyrene to 240mL of concentrated nitric acid, condense and reflux at 80°C for 30h, wash the acid in the solution by diluting the obtained mixture with deionized water, and finally remove large particles with a 220nm filter membrane, and then dry to obtain trinitrate Pyrene powder.

[0059] 2) Take 0.1 g of trinitropyrene obtained in the first step, dissolve 2.5 g of polyethyleneimine in 10 mL of deionized water, stir and mix with trinitropyrene, put it into a microwave reactor, and react at 170 ° C for 80 min.

[0060] 3) The black liquid obtained in step 2 is passed through a 220nm filter membrane, and the filtrate is transferred to the dichloromethane phase, and is filtered with a neutral alumina chromatographic column to remove the small molecular organic matter that is the reaction, and then oven dry to obtain bla...

Embodiment 3

[0062] The present embodiment is a preparation method of near-red second region responsive carbon dots, which comprises the following steps:

[0063] 1) Add 4g of pyrene to 320mL of concentrated nitric acid, condense and reflux at 80°C for 48h, wash the acid in the solution by diluting the obtained mixture continuously with deionized water, and finally remove large particles with a 220nm filter membrane, and then dry to obtain trinitrate Pyrene powder.

[0064] 2) Take 0.1 g of trinitropyrene obtained in the first step, dissolve 0.8 g of polyethyleneimine in 10 mL of deionized water, stir and mix with trinitropyrene, put it into a microwave reactor, and react at 180°C for 2 min.

[0065] 3) passing the black liquid obtained in step 2 through a 220nm filter membrane, transferring the filtrate to the methylene chloride phase, filtering with a neutral alumina chromatographic column to remove the reacted small molecular organics, then drying to obtain black powder, namely NIR -II...

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Abstract

The invention provides a preparation method of near-infrared responsive carbon dots, which comprises the following steps: mixing an aqueous solution of trinitropyrene and polyethyleneimine evenly, reacting at 150-230° C. for 1-120 min in a microwave reactor, and obtaining a reaction product Filtration, chromatography and drying are carried out to obtain the carbon dots. The present invention also relates to the application of the above-mentioned carbon dots. The invention adopts a fast and efficient microwave method to prepare carbon dots for photothermal therapy in the near-infrared region, the carbon dots have excellent photothermal conversion efficiency, and the carbon dots are effectively combined with fluorescent imaging small molecules to achieve in vivo The purpose of in vitro imaging, combined with the small molecule drug doxorubicin, enables the entire system to have two treatment methods, photothermal therapy and chemotherapy. The combined treatment makes the treatment power lower, safer and more efficient.

Description

technical field [0001] The invention belongs to the technical field of carbon quantum dot preparation, and in particular relates to a preparation method and application of near-infrared responsive carbon dots. Background technique [0002] Tumor refers to a new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. Malignant tumors have biological characteristics such as abnormal cell differentiation and proliferation, uncontrolled growth, infiltration and metastasis. Its occurrence is a multi-factor and multi-step complex process, which is closely related to the environment, personal life and eating habits, smoking, alcohol intake, infection, and genetic factors. The treatment of malignant tumors is the frontier and hotspot of current scientific research. Although surgical treatment is the preferred method for many tumors, it has problems such as tumor spread and large patient trauma. Malignant tumors are a serious thre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00C01B32/15A61K41/00A61K31/704A61P35/00
CPCC09K11/65B82Y20/00B82Y40/00C01B32/15A61K41/0052A61K31/704A61P35/00A61K2300/00
Inventor 沈龙祥潘登余耿弼江
Owner SHANGHAI SIXTH PEOPLES HOSPITAL