Plant soft capsule and preparation method and application thereof

A soft capsule and plant technology, applied in the field of plant soft capsule and its preparation, can solve problems such as low production cost and low oil leakage rate, and achieve the effects of low oil leakage rate, excellent film-forming property, and improved production efficiency

Pending Publication Date: 2019-08-02
JIANGSU ALAND NOURISHMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problem that the existing plant soft capsule technology cannot meet low cost and high quality at the same time, and provide a plant soft capsule with industrial application and a preparation method thereof; the present invention controls the weight average molecular weight of carrageenan, and Starch, plasticizer and water prepare the plant soft capsule of excellent performance; Plant soft capsule of the present invention has lower production cost than the plant soft capsule of the prior art, and product quality has reached the requirement of gelatin soft capsule; Under the premise of high production efficiency, low oil leakage rate and rupture time meet the United States Pharmacopoeia (USP) standard

Method used

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  • Plant soft capsule and preparation method and application thereof
  • Plant soft capsule and preparation method and application thereof
  • Plant soft capsule and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Effects of Different Types of Carrageenan on the Prepared Soft Capsules

[0058] 1) chemical glue process

[0059] Weigh 8KG of different types of carrageenan, 30KG of hydroxypropyl starch, 15KG of glycerin and 47KG of purified water and place them in a chemical glue tank, heat to 80-90°C to swell the glue, keep it warm for 20-120min, and degas until the glue is clear translucent glue;

[0060] 2) Shot rolling process

[0061] Select 22 drops of cylindrical soft capsule mold, heat the rubber box of the pill rolling machine to 80-95°C, heat the drum to 20-40°C, supply glue, set the rubber thickness to 0.80mm, and machine speed to 1.5rpm to roll the pills. The content is linseed oil, then dried until the hardness of the capsules meets the requirements (50-70N), the pellets are selected, and finally packaged.

[0062] The seam rate, content loading, and oil leakage rate of soft capsules prepared from different types of carrageenan were tested, and the results are shown ...

Embodiment 2

[0069] Effects of Carrageenan with Different Weight-average Molecular Weight on the Soft Capsules Prepared

[0070] 1) chemical glue process

[0071] Weigh 8KG of type I (Iota) carrageenan, 30KG of hydroxypropyl starch, 15KG of glycerin and 47KG of purified water with different weight-average molecular weights and place them in a chemical tank, heat to 80-90°C to swell the glue, and then keep it warm for 20-120min , degas until the glue is clear and translucent to get the glue;

[0072] 2) Shot rolling process

[0073] Select 22 drops of cylindrical soft capsule mold, heat the rubber box of the pill rolling machine to 80-95°C, heat the drum to 20-40°C, supply glue, set the rubber thickness to 0.80mm, and machine speed to 1.5rpm to roll the pills. The content is linseed oil, then dried until the hardness of the capsules meets the requirements (50-70N), the pellets are selected, and finally packaged.

[0074] The seam rate, content loading and oil leakage rate of soft capsule...

Embodiment 3

[0079] The impact of different drum temperatures on the properties of the prepared soft capsules:

[0080] 1) chemical glue process

[0081] Take by weighing 8KG type I (Iota) carrageenan (the weight average molecular weight of carrageenan is 1.50±0.1×10 6 ), 30KG hydroxypropyl starch, 15KG glycerin and 47KG purified water are placed in a glue tank, heated to 80-90°C to swell the glue, keep it warm for 20-120min, degas until the glue is clear and translucent to obtain glue;

[0082] 2) Shot rolling process

[0083] Select 22 drops of cylindrical soft capsule mold, heat the rubber box of the pill rolling machine to 80-95°C, heat the drum, supply glue, set the rubber thickness to 0.80mm, machine speed 1.5rpm to roll pills, and the content is flax Seed oil, then dried until the hardness of the capsules meets the requirements (50-70N), the pellets are selected, and finally packed.

[0084] The rubber seam ratio, content content and oil leakage rate of soft capsules prepared at ...

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Abstract

The invention belongs to the technical field of soft capsules, and particularly relates to a plant soft capsule and a preparation method and application thereof. By controlling weight-average molecular weight of carrageenan to be 1.2*10<6>-2.0*10<6>, the plant soft capsule with excellent performance is prepared with starch, a plasticizer and water; compared with a plant soft capsule in the prior art, the plant soft capsule provided by the invention is lower in production cost, and the product quality reaches the requirements of a gelatin soft capsule; under the premise of high production efficiency, low oil leaking rate is realized and fracture time reaches the standard of United States Pharmacopeia (USP). The plant soft capsule prepared by the preparation method provided by the inventioncan be filled with active components as contents, and is used for preparing multiple drugs, functional foods or dietary nutrition supplements.

Description

technical field [0001] The invention belongs to the technical field of soft capsules, and in particular relates to a plant soft capsule, a preparation method and application thereof. Background technique [0002] Soft capsules are widely used in fields such as medical treatment and pharmaceutical products and food. The rubber skins of commonly used soft capsule products use gelatin as the main raw material. Gelatin commonly used in industry is mostly from pigs and cattle. In recent years, there have been frequent reports of food safety incidents of capsules. Because industrial gelatin contains a lot of heavy metal ions, it is extremely harmful; although gelatin is low in cost, it has cross-linking problems, which can easily make soft capsules unstable. , affecting the storage and transportation of soft capsule products. At the same time, due to the animal origin of gelatin, gelatin-based soft capsules do not meet the dietary habits and requirements of halal or vegetarianis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A23P10/30A23P10/35
CPCA61K9/4816A61K47/36A23P10/30A23P10/35A23V2002/00A23V2200/224A23L29/256A23L29/212A23L27/34A23L29/10A23L5/42A23L33/115A23L33/15A23L33/16A23F5/00A23F3/00A23L33/105A23L2/52A23L33/30A61K9/4808A61K9/4833A61K47/10
Inventor 张国栋洪靖夏旭东张兴史解矛商琛栋丁报荣
Owner JIANGSU ALAND NOURISHMENT
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