Hydrophilic coating solution for intervention catheter, preparation method and use method thereof

A technology for hydrophilic coatings and interventional catheters, applied in catheters, coatings, pharmaceutical formulations, etc., can solve the problems of loss of hydrophilic lubrication of the coating system, lack of adhesion of interventional catheters, insufficient wear resistance of coatings, etc., to achieve Excellent hydrophilicity, solve the effect of insufficient firmness, and increase the firmness

Pending Publication Date: 2019-08-02
KOSSEL MEDTECH SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Most of the early hydrophilic coating systems did not use chemical reactions when curing. For example, US patents US4589873, US4835003, US4875287, US5331027, US5509899, ​​US5620738 and US6042876 all disclosed hydrophilic lubricating coatings containing PVP. The characteristics of this type of coating Yes, the top layer is coated with PVP, but neither the coating where PVP is located nor the bottom coating introduces a cross-linked structure. PVP is easy to fall off after absorbing water and swelling, which will make the entire coating system lose the effect of hydrophilic lubrication
[0008] In the prior art, there is a problem that the hydrophilic coating lacks sufficient adhesion to the interventional catheter, resulting in insufficient wear resistance of the coating. Therefore, it is necessary to construct a new coating solution system to achieve the hydrophilicity and lubricity of the interventional catheter. and wear resistance requirements

Method used

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  • Hydrophilic coating solution for intervention catheter, preparation method and use method thereof
  • Hydrophilic coating solution for intervention catheter, preparation method and use method thereof

Examples

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preparation example Construction

[0046] The preparation method of the hydrophilic coating solution for the above-mentioned interventional catheter comprises the following steps:

[0047] Add organic solvent, deionized water and hydrophilic compound into the container, stir at room temperature until the hydrophilic compound is completely dissolved; then add acrylate compound, surfactant and citrate plasticizer, stir for 30-60min; then add light Initiator, stir until the solution is clear, that is, too.

[0048] The method for using the hydrophilic coating solution for the above-mentioned interventional catheter comprises the following steps:

[0049] Coating step: coating the hydrophilic coating solution on the surface of the intervention catheter by dipping, spraying or brushing;

[0050] Steps of UV curing: placing the interventional catheter after the coating step under ultraviolet light with an irradiance of 5-100mW / cm2, and curing for 100-300s to obtain an interventional catheter with a hydrophilic coati...

Embodiment 1

[0052] A hydrophilic coating solution for interventional catheters. Take 2.5 g of polyvinylpyrrolidone with a molecular weight of 500,000 Daltons, 85 g of absolute ethanol, and 12.3 g of deionized water in a container, stir at room temperature, The pyrrolidone was completely dissolved. Add 0.5g of a mixture of ethylene glycol diacrylate and polyethylene glycol diacrylate, 0.05g of polyether-terminated polysiloxane, 0.1g of acetyl tributyl citrate, continue stirring for 30min, and then add 1-hydroxy Cyclohexyl phenyl ketone 0.05g, stirred to a transparent and clear state, that is.

[0053] The method for using the hydrophilic coating solution for the above-mentioned interventional catheter comprises the following steps:

[0054] Coating step: coating the hydrophilic coating solution on the surface of the interventional catheter by means of dip coating;

[0055] The step of ultraviolet light curing: the interventional catheter after the coating step is placed under the ultravi...

Embodiment 2

[0057] A hydrophilic coating solution for interventional catheters. Take 3 g of polyvinylpyrrolidone with a molecular weight of 500,000 Daltons, 80 g of isopropanol, and 15.92 g of deionized water in a container, and stir at room temperature until the polyvinyl pyrrolidone Pyrrolidone dissolved completely. Add 0.9 g of a mixture of propoxylated glycerol triacrylate, ethylene glycol diacrylate and polyethylene glycol diacrylate, 0.1 g of polydimethylsiloxane, 0.1 g of acetyl tributyl citrate, Continue stirring for 60 min, then add 0.08 g of a mixture of 1-hydroxycyclohexyl phenyl ketone and 2-methyl-1-(4-methylthiophenyl)-2-morpholine-1-propanone, and stir until transparent and clear Status, that is.

[0058] The method for using the hydrophilic coating solution for the above-mentioned interventional catheter comprises the following steps:

[0059] Coating step: coating the hydrophilic coating solution on the surface of the interventional catheter by brushing;

[0060] Steps...

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Abstract

The invention discloses a hydrophilic coating solution for an intervention catheter. The hydrophilic coating solution comprises the following components in parts by weight: 1-5 parts of hydrophilic compound, 0.1-1.5 parts of acrylics compound, 0.05-0.2 part of surfactant, 0.02-0.15 part of photoinitiator, 0.05-0.5 part of citrate plasticizer, 65-90 parts of organic solvent and 5-30 parts of deionized water. The invention also discloses a preparation method and a use method of the hydrophilic coating solution for the intervention catheter. The hydrophilic coating solution for the intervention catheter provided by the invention is capable of endowing the intervention catheter with excellent hydrophilicity, lubricity and abrasion performance; firmness and stability of the coating formed on the intervention catheter surface are obviously promoted; the preparation method thereof has the advantages of simple process, convenience in operation and benefit in industrial production.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a hydrophilic coating solution for interventional catheters and a preparation method and application method thereof. Background technique [0002] Intravascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, and removal of intravascular thrombus or foreign body. Pain, treatment risk is small, and treatment cost is relatively low, so interventional diagnosis and treatment technology has been widely promoted and used in the medical field. [0003] Intravascular interventional diagnosis and treatment technology is to use interventional catheters to reach distant diseased parts in the body through the vascular lumen, such as coronary arteries and other vascular parts, and then inject diagnostic agents or insert devices to achieve diagnosis and minimally invasive treatment of remote parts of the body. purpose of treatment. Interv...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14C08F271/02C08F222/14C08F222/20
CPCA61L29/085A61L29/08A61L29/14C08F271/02A61L2400/10A61L2420/02C08L39/06C08L71/02C08F222/1063
Inventor 汪令生刘继勇谭茂彩王志高胡清
Owner KOSSEL MEDTECH SUZHOU
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