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A coating for forming a hydrophilic coating on the surface of catheter and its preparation and use method

A technology of hydrophilic coating and primer, applied in the field of medical devices, can solve the problems of toxicity of isocyanate compounds, insufficient coating firmness, insufficient coating wear resistance, etc., and achieve excellent wear resistance, compensation performance and function Insufficient, the effect of low curing temperature

Active Publication Date: 2018-02-16
BEIJING DEMAX MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this system, the substrate is not connected with other components by chemical reaction, so the coating firmness is still insufficient
In addition, isocyanate compounds are toxic and pose a safety hazard to health
[0016] It can be seen that, compared with the non-reactive hydrophilic polymer, the reactive hydrophilic polymer has better coating firmness, but the other components matched with it in the coating are not closely connected to each other. And the lack of sufficient adhesion to the catheter, the coating still has the problem of insufficient wear resistance, so it is necessary to construct a new coating system to achieve the purpose of both hydrophilic lubrication and wear resistance of the interventional catheter, and it is still necessary to provide new technologies to Get Higher Performance Catheter Coatings

Method used

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  • A coating for forming a hydrophilic coating on the surface of catheter and its preparation and use method
  • A coating for forming a hydrophilic coating on the surface of catheter and its preparation and use method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of side carboxyl group-containing polyurethane (CPU): use solvent method to synthesize side carboxyl group-containing polyurethane, add polyether or polyester diol and diisocyanate into the reactor, heat up to 80°C, stir for 1 hour to obtain prepolymer, Add 2,2-dimethylol propionic acid and 1,4-butanediol, react for 2 hours, add N,N-dimethylformamide, continue the reaction for 1 hour, add dibutyltin dilaurate, and then Reacted for 8 hours, down to room temperature, the solution in the reactor was poured into a container with deionized water, a white precipitate was precipitated, collected the precipitate and washed 3 times with deionized water, placed in a vacuum drying oven, at 90 After vacuum drying at ℃ for 48 hours, a transparent block product was obtained, which was granulated to obtain a side carboxyl group-containing polyurethane masterbatch.

[0042] Wherein, described polyether or polyester diol is selected from polyoxypropylene diol (PPG), polytetr...

Embodiment 2

[0049] Water-based polyurethane, trimethylolpropane-tris[3-(2-methylaziridinyl)]propionate, and deionized water were added to the container, and stirred at room temperature for 30 minutes to obtain a primer, in which three The quality of methylolpropane-tris[3-(2-methylaziridinyl)]propionate is 1% of the waterborne polyurethane quality, and the quality of deionized water is 80% of the total quality of the primer. Add side carboxyl group-containing polyurethane CPU-1, polymethyl vinyl ether-maleic anhydride, polyethylene glycol monomethyl ether, and N,N-dimethylformamide into the container, and stir at room temperature for 30 minutes to obtain Top coat, wherein the mass ratio of CPU-1 to polymethyl vinyl ether-maleic anhydride is 1:0.1, and the quality of polyethylene glycol monomethyl ether is 1% of the mass of polymethyl vinyl ether-maleic anhydride , The quality of N,N-dimethylformamide is 80% of the total mass of the top coat. Polymethyl vinyl ether-maleic anhydride is a p...

Embodiment 3

[0054] Water-based polyurethane, trimethylolpropane-tris(3-aziridinyl)propionate, and deionized water were added to the container, and stirred at room temperature for 30 minutes to obtain a primer, wherein trimethylolpropane-tris(3-aziridinyl)propionate The quality of (3-aziridinyl) propionate is 2% of the waterborne polyurethane quality, and the quality of deionized water is 83% of the total quality of the primer. Add side carboxyl group-containing polyurethane CPU-2, polymethyl vinyl ether-maleic anhydride, polyethylene glycol monomethyl ether, and N,N-dimethylacetamide into the container, and stir at room temperature for 30 minutes to obtain Top coat, wherein the mass ratio of CPU-2 to polymethyl vinyl ether-maleic anhydride is 1:0.5, and the quality of polyethylene glycol monomethyl ether is 3% of the mass of polymethyl vinyl ether-maleic anhydride , the quality of N,N-dimethylacetamide is 83% of the total mass of the top coat. Polymethyl vinyl ether-maleic anhydride is a...

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Abstract

The invention relates to a coating for forming a hydrophilic coating on the surface of a catheter and a method for preparing and using the coating. The coating includes a primer and a top coating. The primer includes water-based polyurethane, multifunctional aziridine derivatives and deionized water, and the top coating Contains side carboxyl polyurethane, polymethyl vinyl ether-maleic anhydride and organic solvents, each component forms a cross-linked structure during curing, the bottom and top of the coating are tightly bonded by covalent bonds, and at the same time firmly adhere to the surface of the catheter, The coating has excellent hydrophilic lubricity and wear resistance, and is suitable for the hydrophilic lubrication treatment of medical interventional catheters and other instruments in the technical field of intravascular interventional diagnosis and treatment.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a coating for forming a hydrophilic coating on the surface of a catheter and a preparation and application method thereof. Background technique [0002] Intravascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, removal of intravascular thrombus or foreign body, etc. Compared with traditional medical technology, it is not only convenient to operate, but also reduces the pain of patients due to the low trauma of interventional treatment , the risk of treatment is small, and the cost of treatment is relatively low, so this technology has been widely promoted and used in the medical field. Intravascular interventional diagnosis and treatment technology is to use interventional catheters to reach distant diseased parts in the body through the vascular lumen, such as coronary arteries and other vascular parts, and then inject dia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D175/04C09D175/08C09D175/06C08G18/10C08G18/32C08G18/34B05D5/04B05D7/24A61L29/08
Inventor 王兴元戴华英
Owner BEIJING DEMAX MEDICAL TECH
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