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Interventional catheter surface treatment method and interventional catheter

An interventional catheter and surface treatment technology, applied in the field of interventional catheter surface treatment and interventional catheter, can solve the problems of insufficient wear resistance of coating, toxicity of isocyanate compound, lack of catheter adhesion, etc., and achieve the effect of firm hydrophilic and lubricating performance.

Active Publication Date: 2015-04-29
BEIJING DEMAX MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this system, the substrate is not connected with other components by chemical reaction, so the coating firmness is still insufficient
In addition, isocyanate compounds are toxic and pose a safety hazard to health
[0007] The coating still suffers from insufficient abrasion resistance due to the persistent lack of adequate adhesion of the hydrophilic polymer to the catheter
Especially in medical interventional catheters based on materials such as ethylene-tetrafluoroethylene copolymer, hexafluoropropylene-tetrafluoroethylene copolymer, polypropylene, polyethylene, etc., such as outer sheath tubes, dilation tubes or It will be more difficult to form a strong hydrophilic coating with the existing technology
In addition, when coating on these low surface tension substrates, the wetting, leveling, uniformity and other properties of the coating will be problematic, making it almost difficult to apply

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation: Preparation of coating solution: Add polymethyl vinyl ether-maleic anhydride and N,N-dimethylformamide into a container, and stir at room temperature for 30 minutes to obtain a coating solution. The mass of N,N-dimethylformamide is 90% of the total mass of the coating solution. In this embodiment, polymethyl vinyl ether-maleic anhydride is a product of Sigma-Aldrich Company with a number average molecular weight of 80,000. (the following examples are the same). Typical coating solutions are formulated prior to coating.

[0043] making process:

[0044] S100: Place the interventional catheter in the sample chamber of the plasma generator, conduct plasma treatment after argon gas is introduced, the discharge power is 10W, and the treatment time is 1min. After the treatment is completed, the interventional catheter is taken out;

[0045] S200: Soak the interventional catheter obtained in step S100 in a dioxane solution of glycidyl methacrylate at a concentr...

Embodiment 2

[0051] Preparation: Preparation of coating solution: Add polymethyl vinyl ether-maleic anhydride and N,N-dimethylacetamide into a container, and stir at room temperature for 30 minutes to obtain a coating solution. The mass of N,N-dimethylacetamide is 91% of the total mass of the coating solution.

[0052] making process:

[0053] S100: Place the interventional catheter in the sample chamber of the plasma generator, conduct plasma treatment after argon gas is introduced, the discharge power is 50W, and the treatment time is 2 minutes. After the treatment is completed, the interventional catheter is taken out;

[0054] S200: Soak the interventional catheter obtained in step S100 in N,N-dimethylacetamide solution of glycidyl methacrylate with a concentration of 10 wt% for grafting modification, the grafting temperature is 40°C, and the grafting time is 6h, after the reaction is completed, take out the intervention catheter, soak it in a container with acetone for 30 minutes and...

Embodiment 3

[0060] Preparations: Preparation of coating solution: Add polymethyl vinyl ether-maleic anhydride and N-methylpyrrolidone into a container, stir at room temperature for 30 minutes to obtain a coating solution. Wherein the mass of N-methylpyrrolidone is 92% of the total mass of the coating solution.

[0061] making process:

[0062] S100: Place the interventional catheter in the sample chamber of the plasma generator, conduct plasma treatment after argon gas is introduced, the discharge power is 100W, and the treatment time is 3 minutes. After the treatment is completed, the interventional catheter is taken out;

[0063] S200: Soak the interventional catheter obtained in step S100 in N-methylpyrrolidone solution of glycidyl methacrylate at a concentration of 20 wt% for grafting modification, the grafting temperature is 50°C, the grafting time is 10h, and the reaction is completed Finally, take out the interventional catheter, soak it in a container containing acetone for 30 mi...

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PUM

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Abstract

The invention provides an intervention catheter surface treatment method and an intervention catheter. The method comprises the steps of pre-treatment, grafting and modification treatment, coating application, and post-treatment. With the method, problems of inadequate intervention catheter surface paint wetness and inadequate hydrophilic coating firmness are effectively solved. According to the invention, approaches such as plasma treatment, grafting, coating system application, and the like are combined, such that covalent bond connection between the coating and a catheter substrate is realized. With the treatment, friction force on the intervention catheter in a water environment is reduced by more than 90%.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a surface treatment method for an interventional catheter and an interventional catheter obtained by processing the method. Background technique [0002] Intravascular interventional diagnosis and treatment technology is widely used in clinical angiography, angioplasty, removal of intravascular thrombus or foreign body, etc. Compared with traditional medical technology, it is not only convenient to operate, but also reduces the pain of patients due to the low trauma of interventional treatment , the risk of treatment is small, and the cost of treatment is relatively low, so this technology has been widely promoted and used in the medical field. Intravascular interventional diagnosis and treatment technology is to use interventional catheters to reach distant diseased parts in the body through the vascular lumen, such as coronary arteries and other vascular parts, and then inject di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08J7/04C08J7/12C09D171/02A61L29/08A61L29/14
Inventor 王兴元戴华英
Owner BEIJING DEMAX MEDICAL TECH
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