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Flexible brain-computer interface electrode with enhancement-type wrinkle micro-structure and preparation method

A brain-computer interface and microstructure technology, applied in the field of biomedical engineering, can solve problems such as difficult to achieve specific surface area, difficult to obtain specific surface area, low wrinkle amplitude, etc. Improved effect

Inactive Publication Date: 2019-08-13
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that it is difficult to achieve a large specific surface area by directly depositing Parylene C thin films on PDMS.
[0007] In summary, the wrinkled microstructures reported so far are rarely applied to neural microelectrodes, and although the wrinkled microstructure can be obtained by depositing Parylene C on the PDMS elastic polymer substrate, the wrinkle amplitude is low, and it is difficult to obtain a larger wrinkle microstructure. large specific surface area

Method used

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  • Flexible brain-computer interface electrode with enhancement-type wrinkle micro-structure and preparation method
  • Flexible brain-computer interface electrode with enhancement-type wrinkle micro-structure and preparation method
  • Flexible brain-computer interface electrode with enhancement-type wrinkle micro-structure and preparation method

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Experimental program
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Effect test

Embodiment 1

[0059] Such as figure 1 As shown, this embodiment provides a schematic diagram of a preferred structure of a flexible brain-computer interface electrode with an enhanced wrinkled microstructure, wherein the electrode is composed of an elastic polymer substrate 1, a bottom polymer insulating layer 2, a metal electrode layer 3, and a top layer of polymer The encapsulation layer 4 and the electrode modification layer 5 are composed of five parts.

[0060] The elastic polymer base 1 is formed by setting a layer of elastic polymer film above the base, and silicone oil is mixed into the elastic polymer film, and the mass percentage of the silicone oil added is 30% of the total mass of the elastic polymer film and the silicone oil. A first layer of polymer film is deposited on the elastic polymer substrate 1, and the first layer of polymer film is used as the underlying polymer insulating layer 2 to obtain a uniformly distributed micro-scale wrinkled structure, compared with the elas...

Embodiment 2

[0080] This embodiment provides a method for preparing a flexible brain-computer interface electrode with an enhanced wrinkled microstructure, such as figure 2 As shown, it is a schematic diagram of the formation of enhanced wrinkled microstructure. By adding silicone oil to uncured PDMS or Ecoflex, and then extracting with isopropanol, in-plane shrinkage will occur in the elastic polymer substrate 1, and the first layer is deposited. When the stress is released in the polymer film, an enhanced wrinkled morphology is produced. The material of the first polymer film is Parylene C.

[0081] Such as image 3As shown in (a)-(j), it is the preparation method of the above-mentioned flexible brain-computer interface electrode with enhanced folded microstructure, which is prepared according to the following steps:

[0082] 1), such as image 3 Shown in (a), on the 500 micron thick silicon chip, thermally evaporate the aluminum metal release layer of 300 nanometer thickness;

[00...

Embodiment 3

[0096] In this example, a method for preparing a flexible brain-computer interface electrode with enhanced wrinkled microstructure is provided. The specific implementation steps are the same as in Example 2, except that in step 2), the elastic polymer substrate 1 used It is Ecoflex, which is an ultra-soft silica gel with a modulus of 60kPa. By depositing Parylene C on its surface, a completely different wrinkle morphology can be obtained from the PDMS elastic polymer substrate 1.

[0097] Such as Figure 5 As shown, the electrode with enhanced wrinkled microstructure prepared by the above method was compared (such as Figure 5 Shown in (b)) and the electrode prepared by depositing Parylene C on Ecoflex without silicone oil pretreatment (not mixed with silicone oil) (such as Figure 5 As shown in (a)), it can be seen that there are almost no obvious wrinkles on the Ecoflex elastic polymer substrate 1 without silicone oil pretreatment, and the maximum amplitude is 0.05 μm, whil...

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Abstract

The invention provides a flexible brain-computer interface electrode with an enhancement-type wrinkle micro-structure and a preparation method. The electrode comprises a substrate, an elastic thin polymer film is arranged on the substrate to form an elastic polymer substrate, the elastic thin polymer film is doped with silicone oil, the first layer of thin polymer film is deposited on the elasticpolymer substrate, through deposition, the first layer of thin polymer film is used as an insulation layer, and wrinkles are automatically generated. Compared with an elastic polymer substrate not treated through the silicone oil, the magnitude of the wrinkles is obviously increased, and the specific surface area is obviously increased. The preparation method is high in compatibility with a micro-electro-mechanical system technology, and the shapes of the obtained enhancement-type wrinkles always keep unchanged in the following process of an imaging electrode layer and a polymer encapsulationlayer; the binding force of an electroplating electrode modified material and an electrode interface can be effectively improved, the stable and reliable electrochemical performance is guaranteed, andtherefore the method has high application value in the field of minitype flexible electrophysiological sensors, particularly brain-computer interface electrodes.

Description

technical field [0001] The invention belongs to a microelectrode in the technical field of biomedical engineering, and in particular relates to a flexible brain-computer interface electrode with an enhanced wrinkled microstructure and a preparation method. Background technique [0002] With the rapid development of brain-computer interface and artificial intelligence technology, accurate and reliable acquisition of brain information has become an essential link. The emergence of flexible neural microelectrodes provides a tool for this purpose, which can be attached to the cerebral cortex to collect EEG signals, which is of great significance for the study of neural circuit functions and the diagnosis of brain lesions. Neurons have a huge number and rich types, how to improve the resolution of signal pickup is getting more and more attention, and the development of high-density electrodes is particularly important. In the case of reducing the size of the electrode point, the...

Claims

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Application Information

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IPC IPC(8): A61B5/0478
CPCA61B5/291
Inventor 刘景全吉博文王明浩郭哲俊王隆春杨斌王晓林
Owner SHANGHAI JIAO TONG UNIV