Synthetic technology of polyhexamethylene biguanide hydrochloride

Abstract

The invention provides a synthesis process of polyhexamethylene biguanide hydrochloride, which belongs to the technical field of chemical product synthesis, and comprises the following steps: (1) dissolving 1,6-dicyanoguanidine hexane and hexamethylenediamine hydrochloride In an organic solvent, an addition reaction occurs at 100-130°C; (2) after the addition reaction, under the action of a catalyst, a self-condensation reaction is carried out at 150-160°C to obtain polyhexamethylene biguanide hydrochloride. There is no VOC emission in the production process, and the product yield is as high as more than 97%. Because the raw materials are easily obtained, the process flow is mild, the process is simple, and the cost is low, it can be industrialized.

Description

technical field [0001] The invention relates to the technical field of chemical product synthesis, in particular to a synthesis process of polyhexamethylene biguanide hydrochloride. Background technique [0002] Polyhexamethylene biguanide hydrochloride is a new type of antibacterial substance with broad-spectrum antibacterial effect and obvious antibacterial effect. Has the ability to kill. [0003] At present, although there are relevant researches on this product in China, there are not many products on the market that can meet this sterilization requirement. The molecular weight of the product is hidden in 1100-1800, and the pH range is 4.0-7.0. The low degree of polymerization leads to short sterilization cycle and low usage. The narrow pH range and other problems are often used in the field of disinfectants. [0004] According to the literature retrieved, the synthesis method of polyhexamethylene biguanide hydrochloride reported abroad is divided into three methods a...

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Problems solved by technology

[0011] The above-mentioned three kinds of synthetic methods each have advantages and disadvantages, but the disadvantage is that when the reaction temperature is low, the conversion rate of the raw material is low, and the molecular weight is also low; when the reaction temperature is relatively high, although the molecular weight of the product can be improved, it is easy to Produce branched or cross-linked products, these by-products are difficult to completely separate from the product by more economical methods, resulting in low product purity, low viscosity, low molecular weight, reducing the use effect and increasing the use cost

A better synthesis method is melt polymerization at high temperature. Although higher yields can be achieved, the viscosity of the reaction system is very high in melt polymerization, which is not conducive to stirring, and it is easy to burn the stirring motor.

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