Nano gel containing platinum nano particles and preparation method and application thereof
A platinum nanoparticle and nanogel technology, applied in the field of drug carrier preparation, can solve the problems of phototoxic lysosome rupture, non-specificity, and easy photobleaching, etc.
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Embodiment 1
[0066] Preparation of mother liquor: Weigh sodium hyaluronate (molecular weight 10kDa to 1000kDa), cisplatin, and adipine, respectively add double distilled water to make an aqueous solution (heating to aid dissolution, if necessary); the concentrations are:
[0067] -Concentration of hyaluronic acid aqueous solution: 1mg / ml to 5mg / ml;
[0068] - Cisplatin aqueous solution concentration: 3mg / ml to 20mg / ml;
[0069] - Concentration of Adipine solution in water: 1 mg / ml to 10 mg / ml.
preparation example 1
[0070] Preparation Example 1. Preparation of Nanogel Containing Platinum Nanoparticles ( figure 1 )
[0071] (1) Add 150 μL of the above cisplatin aqueous solution and 50 μL of double distilled water, add 800 μL of the above hyaluronic acid aqueous solution and mix quickly;
[0072] (2) heating the mixture at 90°C for 0.5 hours to 3 hours;
[0073] (3) Add 250 μL of 30%-100% (v / v) ethanol as a reducing agent, and continue to incubate at 90° C. for 2 hours to 8 hours;
[0074] (4) cooling on ice for 5 minutes to 15 minutes;
[0075] (5) The mixture is transferred to the dialysis bag for dialysis, and the dialysate is double distilled water;
[0076] (6) Store the obtained product at 4°C for future use.
preparation example 2
[0077] Preparation Example 2. Preparation of Nanogel Containing Functional Molecules and Platinum Nanoparticles ( Figure 4 )
[0078] (1) Add 150 μL of the above cisplatin aqueous solution and 50 μL of adipine aqueous solution to 800 μL of hyaluronic acid aqueous solution and mix quickly;
[0079] (2) heating the mixture at 90°C for 0.5 hours to 3 hours;
[0080] (3) Add 250 μL of 30%-100% (v / v) ethanol as a reducing agent, and continue to incubate at 90° C. for 2 hours to 8 hours;
[0081] (4) cooling on ice for 5 minutes to 15 minutes;
[0082] (5) The mixture is transferred to the dialysis bag for dialysis, and the dialysate is double distilled water;
[0083] (6) Store the obtained product at 4°C for future use.
[0084] It should be understood that the atipine in the step (1) is a representative functional molecule, and other dyes or drugs can be used. The reaction volumes described can be scaled up.
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