Olanzapine oral instant film and preparation method thereof
A technology of instant film and olanzapine, which is applied in the field of medicine, can solve the problems of high equipment requirements, difficult process, difficult dispersion, etc., and achieve the effect of simple preparation process, simple process flow and uniform drug content
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[0025] Example 1
[0026] Add 2g of hypromellose to 10mL of distilled water, fully swell it under constant magnetic stirring at 75°C, then dissolve it in an ice bath, add 0.5g of olanzapine and 0.072g of oxalic acid (molar ratio 1:0.5) To this film-forming material glue solution, add 0.4g of propylene glycol and 0.04g of sucralose at the same time, stir at room temperature for 2 hours to obtain a uniform solution, then apply ultrasonic degassing to the glass plate, dry at 50°C for 1 hour, and cut it .
Example Embodiment
[0027] Example 2
[0028] Add 2g of hypromellose to 10mL of distilled water, fully swell it under constant magnetic stirring at 75°C, and then dissolve it in an ice bath. Mix 0.5g of olanzapine and 0.095g of succinic acid (molar ratio 1:0.5) Add to this film-forming material glue solution, at the same time add 0.4g of propylene glycol, 0.04g of sucralose, stir at room temperature for 2h to obtain a uniform solution, ultrasonic degassed, spread on a glass plate, dry at 50℃ for 1h, cut it Got.
Example Embodiment
[0029] Example 3
[0030] Add 2g of hypromellose to 10mL of distilled water, make it fully swelled under constant magnetic stirring at 75℃, and then dissolve it in an ice bath. Mix 0.5g of olanzapine and 0.093g of fumaric acid (molar ratio 1:0.5 ) Was added to this film-forming material glue solution, while adding 0.4g of propylene glycol, 0.04g of sucralose, stirring at room temperature for 2h to obtain a uniform solution, ultrasonic degassing, coating on a glass plate, drying at 50℃ for 1h, cutting Immediately.
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