Sodium alginate/polydopamine composite nanomaterials modified by pvp and its preparation and application
A composite nanomaterial, sodium alginate technology, applied in wave energy or particle radiation treatment materials, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., can solve the complex synthesis process, low photothermal efficiency, Limit the application of tumor treatment and other problems, and achieve the effect of broad application prospects, improved effect, and high photothermal conversion efficiency
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Embodiment 1
[0032] A preparation method of sodium alginate / polydopamine composite nanomaterial modified by PVP, the specific steps are:
[0033] Step 1: 0.2g sodium alginate is dissolved in distilled water (10mL), prepares 2% sodium alginate solution, then, dopamine hydrochloride is dissolved in the above-mentioned solution, stir constantly, obtain the aqueous solution containing sodium alginate and dopamine ( Weight ratio ALG:DA=1:1).
[0034] Step 2: In CaCl 2 2H 2 Tris (Tris) was added to the aqueous solution of O and PVP to adjust the pH=10 to obtain a coagulation bath, wherein, Ca 2+ The ion concentration was 2%, the PVP concentration was 1%, and the Tris concentration was 0.5%.
[0035] Step 3: Using the electrostatic spraying method, spray the aqueous solution containing sodium alginate and dopamine into the coagulation bath at a constant speed using a push injection device, and form a jet under the action of electrostatic force and surface tension. The entire electrostatic sprayi...
Embodiment 2
[0037] The morphology and size of the ALG / PDA-PVP nanogel obtained in Example 1 were observed and measured by a scanning electron microscope. The hydrodynamic size of the particles and their stability are measured by dynamic light scattering. Using FTIR to analyze and measure the structure of ALG / PDA-PVP nanogel, through 4000 ~ 400 cm -1 The transmission mode, collects data at a speed of 32 scans / min. Depend on figure 1 (a, b) It can be seen that the material synthesized in Example 1 has a spherical particle structure.
[0038] analyze figure 1 (c) It can be seen that the infrared spectrum of the ALG / PDA-PVP composite nanomaterial shows that the material is at 3438cm -1 , 1649cm -1 , 1519cm -1 , 1290cm -1 and 1056cm -1 There is an absorption peak. Of which 3500cm -1 The left and right are O-H or N-H stretching vibrations shared by ALG, PDA and PVP. 1650cm -1 The left and right are the C=O stretching vibrations on both ALG and PVP, and the 1520cm -1 The left and ri...
Embodiment 3
[0040] Using a preparation method similar to that in Example 1, the difference is that step 1 also includes: dissolving DOX in an aqueous solution containing sodium alginate and dopamine (the final concentration of DOX is 1 mg / mL); the seaweed modified by PVP is obtained in step 3 After sodium alginate / polydopamine (ALG / PDA) composite nanogel, 2 mL of the prepared sample was centrifuged (10,000 rpm, 10 min), the gel was collected and washed three times with distilled water, and the resulting PVP-modified sodium alginate / polydopamine was collected. (ALG / PDA) composite nanogel and supernatant, and refrigerate the gel and supernatant for later use.
[0041] First use a UV-visible spectrophotometer to measure and draw a standard curve of DOX, and then measure the absorbance of the supernatant at a wavelength of 480nm. According to Lambert-Beer’s law, the concentration of DOX in the supernatant can be determined to calculate the load efficiency. The steps of drug release are as fo...
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