A kind of preparation method of c18-pmh-peg complex

Abstract

The present invention provides a kind of preparation method of C18-PMH-PEG composite, comprising: (1) poly(maleic anhydride-1-octadecene) (C18PMH) and NH 2 ‑PEG‑OCH 3 Mix and dissolve in dichloromethane solution, use metal iron salt and EDC as a catalyst, the mass ratio of metal iron salt and EDC is: 1: (3~5), put the solution under microwave radiation at 80~95°C to catalyze the reaction 3-4 hours, to obtain the initial reaction solution; add 2-(thiophene-2-methyl)phenylboronic acid as a catalyst, and catalyze the reaction under microwave radiation at 45-65°C for 4-7 hours, to obtain the reaction solution; (2) the reaction solution Transfer to a constant temperature water bath at 50-65°C, continue to stir at 150-200rpm for 20-35min, take out the solution and blow dry the solution with nitrogen to obtain the crude product solid powder; (3) dissolve the crude product solid powder with deionized water, dialyze for 36-48h, The white powder of C18-PMH-PEG complex is obtained by vacuum freeze-drying at a temperature of -25--30°C; the present invention performs segmented microwave catalytic reactions according to different catalysts, which not only speeds up the reaction rate, but also shortens the time of C18-PMH-PEG The overall process time of the complex was improved, and the yield of the C18‑PMH‑PEG complex was greatly improved.

Description

Technical field[0001]The invention relates to the technical field of composite materials, in particular to a method for preparing a C18-PMH-PEG complex.Background technique[0002]In the existing preparation process of the RGO-IONP-PEG nano-functional composite, polyethylene glycol is usually used to modify the reduced graphene and ferroferric oxide nano-composite (RGO-IONP nano-composite). In order to be able to effectively modify RGO-IONP nanocomposites, usually firstly, the carboxyl groups on poly(maleic anhydride-1-octadecene) (C18-PMH) are directly grafted with polyethylene glycol (PEG) to prepare The amphiphilic C18-PMH-PEG complex is obtained, and then the C18-PMH-PEG complex is ultrasonically mixed with the RGO-IONP nanocomposite for grafting reaction, thereby obtaining the RGO-IONP-PEG nanofunctional complex. However, at present, when poly(maleic anhydride-1-octadecene) (C18-PMH) and polyethylene glycol (PEG) are used for the grafting reaction, the process time required for p...

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Problems solved by technology

But when adopting poly(maleic anhydride-1-octadecene) (C18-PMH) and polyethylene glycol (PEG) to carry out grafting reaction at present, the process time required for preparation is longer, and reaction rate is slow, and In the existing preparation method, only about 20% of the carboxyl groups can be effectively connected to PEG, resulting in a low yield of the C18-PMH-PEG complex, which ultimately affects the effective modification of the RGO-IONP nanocomposite, making the resulting RGO -The problem of low yield of IONP-PEG nanofunctional complexes

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