Adenosine monophosphate-protected gold-silver alloy nanocluster fluorescence probe, and application thereof in detection of Plasmodium vivax lactate dehydrogenase

An adenosine monophosphate, gold-silver alloy technology, applied in the detection of Plasmodium vivax lactate dehydrogenase, in the field of gold-silver alloy nanocluster fluorescent probes, which can solve the problem of increasing the detection cost and limiting the practical application of the detection method, etc. problem, to achieve the effect of simple structure, good biocompatibility, high stability and water solubility
CN110408380AActive Publication Date: 2019-11-05JILIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN UNIV
Publication Date
2019-11-05

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Abstract

The invention discloses an adenosine monophosphate-protected gold-silver alloy nanocluster fluorescence probe, and an application thereof in the detection of Plasmodium vivax lactate dehydrogenase, and belongs to the technical field of fluorescence probes. The fluorescence probe has the advantages of simple structure, easiness in synthesis, strong stability and good biocompatibility, and can generate large linear fluorescence enhanced response to the Plasmodium vivax lactate dehydrogenase (PvLDH). The response has a wide detection range (0 to 1.0 *10<-6> mol / L) and a high sensitivity, and thedetection limit can reach 3.7 ng / mL. An adjuvant Al<3+> is introduced, so the probe can completely distinguish the Plasmodium vivax lactate dehydrogenase and other types of lactate dehydrogenases. Thedetection method of the invention has the advantages of high speed, simplicity in operation, stable signal, high sensitivity, no pretreatment, and no complicated detection instruments.
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Description

technical field

[0001] The invention belongs to the technical field of fluorescent probes, and in particular relates to a gold-silver alloy nano-cluster fluorescent probe protected by adenosine monophosphate and its application in detection of Plasmodium vivax lactate dehydrogenase. Background technique

[0002] Malaria is a vector-borne infectious disease caused by mosquito bites or blood transfusion of patients with malaria parasites. It kills more than 435,000 people every year (especially children under the age of 5 are the main victims), and seriously threatens human beings. healthy. According to the World Malaria Report 2018, there were approximately 219 million malaria cases in 2017, a slight increase compared to the previous year. There are mainly four kinds of Plasmodium that can parasitize in the human body, namely Plasmodium vivax, Plasmodium malariae, Plasmodium falciparum and Plasmodium ovale, which are the culprits that cause malaria. In the early diagnosis o...

Claims

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