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Rhizoma polygonati fermentation product, preparation method and application thereof

A technology of fermented products and Polygonatum, applied in the direction of bacteria, applications, drug combinations, etc. used in food preparation, can solve the problems of not being suitable for diabetic patients, and achieve the effect of improving the symptoms of diabetes

Active Publication Date: 2019-11-15
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Polygonatum, as a medicinal and edible homologous raw material variety stipulated by the National Health and Family Planning Commission, has a certain effect on relieving diabetes. The small molecular sugar content of Polygonatum Polygonatum is mostly about 10%, and the Polygonatum Polygonatum small molecular sugar content produced in some places exceeds 20%. Because the small molecular sugar content in the Polygonatum Polygonatum of the prior art is high, it is not suitable for diabetics to eat

Method used

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  • Rhizoma polygonati fermentation product, preparation method and application thereof
  • Rhizoma polygonati fermentation product, preparation method and application thereof
  • Rhizoma polygonati fermentation product, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Raw material pretreatment:

[0028] Wash the fresh or dried sealwort, remove the moldy and moth-eaten parts, and crush it. The dry weight of sealwort: water is 1:4, add water to obtain the sealwort slurry, and adjust the pH to 6.5.

[0029] (2) Sterilization:

[0030] The Rhizoma Polygonatum Serum was sterilized at 121°C for 30min in an autoclave.

[0031] (3) Inoculation fermentation:

[0032] Cultured Lactobacillus plantarum CICC 24202 (Lactobacillus plantarum, LP for short), Lactobacillus brevis YM 1301 (Lactobacillus breris, LB for short);

[0033] The bacterial suspension was mixed at a volume ratio of 1:1 to prepare a starter, which was added to the Rhizoma Polygonatum Serum at an inoculum of 10%, and fermented at 36.5°C for 24 hours.

[0034] (4) Freeze drying:

[0035] The fermented product of Polygonatum is quickly frozen at -20°C, dried in a freeze dryer with a vacuum degree of 0.05-0.1 MPa for 24 hours, and then pulverized to obtain a freeze-dried pow...

Embodiment 2

[0039] (1) Raw material pretreatment:

[0040] Wash the fresh sealwort or dry sealwort, remove the moldy and moth-eaten parts, and crush it. The dry weight of sealwort: water is 1:10, add water to obtain the sealwort slurry, and adjust the pH to 6.2.

[0041] (2) Sterilization:

[0042] The Rhizoma Polygonatum Serum was sterilized at 121°C for 30min in an autoclave.

[0043] (3) Inoculation fermentation:

[0044] Mix the suspensions of LP strain and LB strain at a volume ratio of 1:1 to prepare a starter, add 10% of the inoculum into the Rhizoma Polygonatum Porridge, and ferment at 36.5°C for 24 hours.

[0045] (4) Freeze drying:

[0046] The fermented product of Polygonatum is quickly frozen at -20°C, dried in a freeze dryer with a vacuum degree of 0.05-0.1 MPa for 24 hours, and then pulverized to obtain a freeze-dried powder.

[0047] (5) Polygonatum fermented product freeze-dried powder is pretreated and mixed with other auxiliary materials. According to the conventiona...

Embodiment 3

[0049] (1) Raw material pretreatment:

[0050] Wash the fresh sealwort or dry sealwort, remove the moldy and moth-eaten parts, and crush it. The dry weight of sealwort: water is 1:5, add water to obtain the sealwort slurry, and adjust the pH to 6.5.

[0051] (2) Sterilization:

[0052] The Rhizoma Polygonatum Serum was sterilized at 121°C for 30min in an autoclave.

[0053] (3) Inoculation fermentation:

[0054] Mix the suspensions of LP strain and LB strain at a volume ratio of 1:1 to prepare a starter, add 10% of the inoculum into the Rhizoma Polygonatum Porridge, and ferment at 36.5°C for 24 hours.

[0055] (4) Freeze drying:

[0056]The fermented product of Polygonatum is quickly frozen at -20°C, dried in a freeze dryer with a vacuum degree of 0.05-0.1 MPa for 24 hours, and then pulverized to obtain a freeze-dried powder.

[0057] (5) The freeze-dried powder of Polygonatum fermented product is mixed with food raw materials such as Polygonatum extract, licorice extract,...

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Abstract

The invention discloses a rhizoma polygonati fermentation product, a preparation method and an application thereof, which belong to the technical field of biological medicine preparation. The preparation method comprises the following steps: selecting a lactic acid bacteria probiotic strain as a leavening agent, inoculating the leavening agent into sterilized rhizoma polygonati slurry, and fermenting to obtain the rhizoma polygonati fermentation product, wherein the leavening agent is prepared by mixing lactobacillus plantarum and lactobacillus brevis according to the bacterial suspension volume ratio of 1: (0-10), after the leavening agent is inoculated into the sterilized rhizoma polygonati slurry according to an inoculation amount of 1%-30%, and performing fermentation for 10-80 h at the temperature of 20-36.5 DEG C. The invention further discloses the rhizoma polygonati fermentation product and the application of the rhizoma polygonati fermentation product. According to the preparation method disclosed by the invention, small molecular carbohydrates of the rhizoma polygonati are greatly reduced, and the lactobacillus strain with high yield of aminobutyric acid is used for fermenting the rhizoma polygonati, so that the small molecular carbohydrates in the polygonatum sibiricum are removed, and blood sugar reducing related active ingredients such as saponin and rhizoma polygonati polysaccharide in the rhizoma polygonati are reserved; components such as aminobutyric acid generated by fermentation and active components in rhizoma polygonati cooperate to generate the effectof resisting type 2 diabetes mellitus.

Description

technical field [0001] The invention relates to the technical field of biomedicine manufacturing, in particular to a fermented sealwort, a preparation method and an application. Background technique [0002] Diabetes is one of the major diseases threatening human health. Diabetes is the third major disease that endangers human health after cardiovascular and cerebrovascular diseases and tumors. Its complications include hyperlipidemia, diabetic nephropathy, diabetic eye disease, liver damage, and cardiovascular diseases. The first-line drugs for the treatment of diabetes, such as sulfonylureas and biguanides, require long-term medication, and the drug costs are high. High-efficiency, low-toxic antidiabetic drugs or adjuvant therapy products are still a hot spot in the field of biomedicine. [0003] Traditional Chinese medicine has long-term clinical experience in the treatment of diabetes, and many drugs with significant curative effects have been discovered. Among them, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P3/10A23L33/00A23P10/40A61K125/00
CPCA61K36/8969A61P3/10A23L33/00A23P10/40A61K2236/19A23V2002/00A23V2400/121A23V2400/169A23V2200/328
Inventor 李发荣李继霞高静茹吴臻郑鹏王志强崔浪军张宝善韩萌
Owner SHAANXI NORMAL UNIV
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