A kind of drug-loaded bacterial outer membrane vesicle and its preparation method and application

A technology of outer membrane vesicles and bacteria, applied in antibacterial drugs, pharmaceutical formulations, microcapsules, etc., can solve the problems of less research and achieve broad application prospects
CN110478331BActive Publication Date: 2022-02-18MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2022-02-18

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Abstract

The invention discloses a drug-loaded bacterial outer membrane vesicle and its preparation method and application, in particular to a drug-loaded bacterial outer membrane vesicle prepared by means of liposomes and its preparation method and application. Application in the preparation of antibacterial drugs. The invention provides a method for preparing a preparation containing drug-loaded bacterial outer membrane vesicles, comprising the following steps: using the preparation containing drug-loaded liposomes and the preparation containing bacterial outer membrane vesicles as raw materials to prepare drug-loaded liposomes containing Preparation of Bacterial Outer Membrane Vesicles. The invention also protects a method for preparing drug-loaded bacterial outer membrane vesicles, comprising the following steps: using drug-loaded liposomes and bacterial outer membrane vesicles as raw materials to prepare drug-loaded bacterial outer membrane vesicles. The invention also protects an antibacterial drug, which contains the preparation containing the drug-loaded bacterial outer membrane vesicle or the drug-loaded bacterial outer membrane vesicle. The invention has broad application prospects in the fields of drug delivery and antibacterial drug development.
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Description

technical field

[0001] The present invention relates to a drug-loaded bacterial outer membrane vesicle and its preparation method and application, in particular to a drug-loaded bacterial outer membrane vesicle prepared by means of liposomes and its preparation method and application. Application of antibacterial drugs. Background technique

[0002] Bacterial outer membrane vesicles, which are evolutionarily conserved, are nanoscale functional vesicles released by bacteria to the outside world. They were first discovered in 1967 by Chatterjee et al. Outer membrane vesicle, OMV). The structure of OMV is similar to that of liposome, its diameter is usually between 20-300nm, the main body is phospholipid bilayer, in addition, it also includes bacterial outer membrane and periplasmic components, such as periplasmic protein, outer membrane protein, cytoplasmic protein, Peptidoglycan, lipopolysaccharide, DNA, RNA, various enzymes related to virulence, etc. All Gram-negative bac...

Claims

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