Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method used for preparing diclofenac sodium surface molecular imprinting polymer in water phase taking ZIF-67 as catalyst

A technology of surface molecular imprinting and ZIF-67, applied in chemical instruments and methods, other chemical processes, etc., to achieve the effect of low cost, good selection and recognition ability, and uniform particle size

Active Publication Date: 2019-11-26
HENAN NORMAL UNIV
View PDF5 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, most of the current molecularly imprinted polymers are prepared in toxic organic solvents such as acetonitrile, chloroform, and toluene. In order to avoid secondary pollution caused by highly toxic organic solvents, how to realize the preparation of molecularly imprinted polymers in green medium water has become a research topic. Hotspots

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method used for preparing diclofenac sodium surface molecular imprinting polymer in water phase taking ZIF-67 as catalyst
  • Method used for preparing diclofenac sodium surface molecular imprinting polymer in water phase taking ZIF-67 as catalyst

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] In a 250 mL conical flask, add 0.1776 g of 1-allyl-3-vinylimidazole tetrafluoroborate, 0.1593 g of diclofenac sodium, 0.2 g of ZIF-67 and 50 mL of pure water, respectively, and shake at 30 °C for pre-treatment. After 4 h of polymerization, 1.8500 g of N,N'-methylenebisacrylamide and 10 mg of azobisisobutyronitrile were added in sequence, and then the polymerization reaction was shaken in a water bath at 60 °C for 24 h. The obtained product was treated with methanol / acetic acid (V :V=9:1) mixed solution Soxhlet extraction for 48 h to remove diclofenac sodium, then rinsed with methanol to neutrality, and then vacuum-dried at 60 ℃ to obtain the target product diclofenac sodium surface molecularly imprinted polymer. The preparation method of the non-molecularly imprinted polymer on the surface of diclofenac sodium is the same as above, except that diclofenac sodium is not added in the process.

Embodiment 2

[0022] In a 250 mL conical flask, add 0.222 g of 1-allyl-3-vinylimidazole tetrafluoroborate, 0.1593 g of diclofenac sodium, 0.3 g of ZIF-67 and 50 mL of pure water, respectively, and shake at 30 °C for pre-treatment. After 4 h of polymerization, 1.5418 g of N,N'-methylenebisacrylamide and 10 mg of azobisisobutyronitrile were added in sequence, and then the polymerization reaction was shaken in a water bath at 60 °C for 24 h. The obtained product was treated with methanol / acetic acid (V :V=9:1) mixed solution Soxhlet extraction for 48 h to remove diclofenac sodium, then rinsed with methanol to neutrality, and then vacuum-dried at 60 ℃ to obtain the target product diclofenac sodium surface molecularly imprinted polymer. The preparation method of the non-molecularly imprinted polymer on the surface of diclofenac sodium is the same as above, except that diclofenac sodium is not added in the process.

Embodiment 3

[0024] In a 250 mL conical flask, add 0.1776 g of 1-allyl-3-vinylimidazole tetrafluoroborate, 0.1593 g of diclofenac sodium, 0.3 g of ZIF-67 and 50 mL of pure water, respectively. After 4 h of polymerization, 1.5418 g of N,N'-methylenebisacrylamide and 10 mg of azobisisobutyronitrile were added in sequence, and then the polymerization reaction was shaken in a water bath at 60 °C for 24 h. The obtained product was treated with methanol / acetic acid (V :V=9:1) mixed solution Soxhlet extraction for 48 h to remove diclofenac sodium, then rinsed with methanol to neutrality, and then vacuum-dried at 60 ℃ to obtain the target product diclofenac sodium surface molecularly imprinted polymer. The preparation method of the non-molecularly imprinted polymer on the surface of diclofenac sodium is the same as above, except that diclofenac sodium is not added in the process.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
adsorption capacityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method used for preparing a diclofenac sodium surface molecular imprinting polymer in water phase taking ZIF-67 as catalyst. According to the method, metal organic frameworkmaterial ZIF-67 is taken as a carrier, water is taken as a pore forming agent and a solvent, diclofenac sodium is taken as a template molecule, 1-allyl-3-vinyl imidazole tetrafluoro borate is taken asa functional monomer, N,N'-methylenebis(2-propenamide) is taken as a crosslinking agent, azodiisobutyronitrile is taken as an initiator, oscillation polymerization is carried out at 50 to 70 DEG C toprepare the target product diclofenac sodium surface molecular imprinting polymer. The preparation process is simple; cost is low; excellent selective separation enrichment effect on Diclofenac Sodium left in environment samples is achieved; and the application prospect in the field of Diclofenac Sodium purifying is promising.

Description

technical field [0001] The invention belongs to the technical field of the synthesis of molecularly imprinted polymers and the purification treatment of non-steroidal anti-inflammatory drugs, in particular to a method for preparing the surface molecularly imprinted polymer of diclofenac sodium in an aqueous phase by using ZIF-67 as a carrier. Background technique [0002] Diclofenac sodium is a non-steroidal anti-inflammatory drug whose mechanism of action is to inhibit the synthesis of prostaglandins to exert anti-inflammatory and analgesic effects. At present, its global annual consumption exceeds 940 t, and the consumption will increase year by year. Diclofenac sodium has been detected in environmental media such as water and soil. Studies have shown that diclofenac sodium can cause kidney function decline in birds and even be fatal to vultures, so it is important to detect diclofenac sodium in the environment. [0003] Currently, the more commonly used detection method...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/38C08F226/06C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08F222/385C08J9/26C08F226/06
Inventor 朱桂芬李宛宛汪瑾刘佳丽张春源上官钰蒿佳怡樊静
Owner HENAN NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com