A method for preparing diclofenac sodium surface molecularly imprinted polymer in aqueous phase using zif-67 as carrier

A technology of surface molecular imprinting and ZIF-67, which is applied in the direction of chemical instruments and methods, and other chemical processes, to achieve the effect of low cost, good selection and recognition ability, and uniform particle size

Active Publication Date: 2021-11-12
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, most of the current molecularly imprinted polymers are prepared in toxic organic solvents such as acetonitrile, chloroform, and toluene. In order to avoid secondary pollution caused by highly toxic organic solvents, how to realize the preparation of molecularly imprinted polymers in green medium water has become a research topic. Hotspots

Method used

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  • A method for preparing diclofenac sodium surface molecularly imprinted polymer in aqueous phase using zif-67 as carrier
  • A method for preparing diclofenac sodium surface molecularly imprinted polymer in aqueous phase using zif-67 as carrier

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Effect test

Embodiment 1

[0020] In a 250 mL Erlenmeyer flask, add 0.1776 g of 1-allyl-3-vinylimidazole tetrafluoroborate, 0.1593 g of diclofenac sodium, 0.2 g of ZIF-67 and 50 mL of pure water, shake at 30 °C After 4 hours of polymerization, 1.8500 g of N,N'-methylenebisacrylamide and 10 mg of azobisisobutyronitrile were added sequentially, and the polymerization reaction was shaken at 60°C in a water bath for 24 hours, and the obtained product was mixed with methanol / acetic acid (V : V=9:1) Soxhlet extraction for 48 h to remove diclofenac sodium, then washed with methanol until neutral, and then dried in vacuum at 60°C to obtain the target product diclofenac sodium surface molecularly imprinted polymer. The preparation method of the non-molecularly imprinted polymer on the surface of diclofenac sodium is the same as above, except that diclofenac sodium is not added in the process.

Embodiment 2

[0022] In a 250 mL Erlenmeyer flask, add 0.222 g of 1-allyl-3-vinylimidazole tetrafluoroborate, 0.1593 g of diclofenac sodium, 0.3 g of ZIF-67 and 50 mL of pure water, shake at 30°C for pre- After 4 hours of polymerization, 1.5418 g of N,N'-methylenebisacrylamide and 10 mg of azobisisobutyronitrile were sequentially added, and the polymerization reaction was shaken at 60°C in a water bath for 24 hours, and the obtained product was mixed with methanol / acetic acid (V : V=9:1) Soxhlet extraction for 48 h to remove diclofenac sodium, then washed with methanol until neutral, and then dried in vacuum at 60°C to obtain the target product diclofenac sodium surface molecularly imprinted polymer. The preparation method of the non-molecularly imprinted polymer on the surface of diclofenac sodium is the same as above, except that diclofenac sodium is not added in the process.

Embodiment 3

[0024] In a 250 mL Erlenmeyer flask, add 0.2664 g of 1-allyl-3-vinylimidazole tetrafluoroborate, 0.1593 g of diclofenac sodium, 0.3 g of ZIF-67 and 50 mL of pure water, shake at 30 °C After 4 hours of polymerization, 1.5418 g of N,N'-methylenebisacrylamide and 10 mg of azobisisobutyronitrile were sequentially added, and the polymerization reaction was shaken at 60°C in a water bath for 24 hours, and the obtained product was mixed with methanol / acetic acid (V : V=9:1) Soxhlet extraction for 48 h to remove diclofenac sodium, then washed with methanol until neutral, and then dried in vacuum at 60°C to obtain the target product diclofenac sodium surface molecularly imprinted polymer. The preparation method of the non-molecularly imprinted polymer on the surface of diclofenac sodium is the same as above, except that diclofenac sodium is not added in the process.

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Abstract

The invention discloses a method for preparing a molecularly imprinted polymer on the surface of diclofenac sodium in an aqueous phase using ZIF-67 as a carrier, using metal-organic framework material ZIF-67 as a carrier, water as a porogen and a solvent, and diclofenac sodium as a template Molecule, 1-allyl-3-vinylimidazole tetrafluoroborate is the functional monomer, N,N'-methylenebisacrylamide is the cross-linking agent, and azobisisobutyronitrile is the initiator. The molecularly imprinted polymer on the surface of diclofenac sodium was prepared by oscillating polymerization at 50-70°C. The molecularly imprinted polymer on the surface of diclofenac sodium prepared by the invention has simple process and low cost, and has a good selective separation and enrichment effect on residual diclofenac sodium in environmental samples, and has broad application prospects in the field of purification treatment of diclofenac sodium.

Description

technical field [0001] The invention belongs to the technical field of the synthesis of molecularly imprinted polymers and the purification treatment of non-steroidal anti-inflammatory drugs, and specifically relates to a method for preparing diclofenac sodium surface molecularly imprinted polymers in aqueous phase using ZIF-67 as a carrier. Background technique [0002] Diclofenac sodium is a non-steroidal anti-inflammatory drug, its mechanism of action is to inhibit the synthesis of prostaglandins to exert anti-inflammatory and analgesic effects. At present, its global annual consumption exceeds 940 tons, and the consumption will increase year by year. Diclofenac sodium has been detected in environmental media such as water and soil. Studies have shown that diclofenac sodium can cause renal function decline in birds and animals, and even have a fatal effect on vultures. Therefore, it is very important to detect diclofenac sodium in the environment. [0003] At present, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/38C08F226/06C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08F222/385C08J9/26C08F226/06
Inventor 朱桂芬李宛宛汪瑾刘佳丽张春源上官钰蒿佳怡樊静
Owner HENAN NORMAL UNIV
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